NP_068605.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
mitochondrial brown fat uncoupling protein 1
NCBI Official Synonym Full Names
uncoupling protein 1
NCBI Official Synonym Symbols
NCBI Protein Information
mitochondrial brown fat uncoupling protein 1
UniProt Protein Name
Mitochondrial brown fat uncoupling protein 1
UniProt Synonym Protein Names
Solute carrier family 25 member 7; Thermogenin
UniProt Synonym Gene Names
UniProt Entry Name
UCP1_HUMAN
NCBI Summary for UCP1
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
UniProt Comments for UCP1
UCP1: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Belongs to the mitochondrial carrier family.
Protein type: Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4q28-q31
Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion
Molecular Function: oxidative phosphorylation uncoupler activity; structural constituent of ribosome
Biological Process: brown fat cell differentiation; mitochondrial transport; proton transport; regulation of transcription from RNA polymerase II promoter; translation
Disease: Obesity
Research Articles on UCP1
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Products associated with UCP1 blocking peptide
Pathways associated with UCP1 blocking peptide
Diseases associated with UCP1 blocking peptide
Organs/Tissues associated with UCP1 blocking peptide
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