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VPS35 peptide :: VPS35 / MEM3 Peptide

Scan QR to view Datasheet Catalog #    MBS426803 VPS35 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VPS35 / MEM3, Peptide

 Also Known As   

VPS35 / MEM3 Immunizing Peptide

 Product Synonym Names    VPS35; MEM3; FLJ10752; FLJ13588; FLJ20388; DKFZp434E1211; DKFZp434P1672; vacuolar protein sorting 35 (yeast); maternal-embryonic 3; vacuolar protein sorting 35 homolog (S. cerevisiae); vacuolar protein sorting 35; VPS35 / MEM3
 Product Gene Name   

VPS35 peptide

[Similar Products]
 Antibody/Peptide Pairs    VPS35 / MEM3 peptide (MBS426803) is used for blocking the activity of VPS35/MEM3 antibody (MBS420450)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-SPESEGPI YEGLIL
 OMIM    601501
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 Species Reactivity    Human, Mouse, Rat, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of VPS35 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for VPS35. It may not necessarily be applicable to this product.
 NCBI GI #    17999541
 NCBI GeneID    55737
 NCBI Accession #    NP_060676.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_018206.5 [Other Products]
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 UniProt Secondary Accession #    Q561W2; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2 [Other Products]
 UniProt Related Accession #    Q96QK1 [Other Products]
 Molecular Weight    91,707 Da
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 NCBI Official Full Name    vacuolar protein sorting-associated protein 35
 NCBI Official Synonym Full Names    VPS35 retromer complex component
 NCBI Official Symbol    VPS35 [Similar Products]
 NCBI Official Synonym Symbols   
MEM3; PARK17
[Similar Products]
 NCBI Protein Information    vacuolar protein sorting-associated protein 35
 UniProt Protein Name    Vacuolar protein sorting-associated protein 35
 UniProt Synonym Protein Names   
Maternal-embryonic 3; Vesicle protein sorting 35
 Protein Family    Vacuolar protein sorting-associated protein
 UniProt Gene Name    VPS35 [Similar Products]
 UniProt Synonym Gene Names    MEM3; hVPS35 [Similar Products]
 UniProt Entry Name    VPS35_HUMAN
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 NCBI Summary for VPS35    This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VPS35    VPS35: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Defects in VPS35 are the cause of Parkinson disease type 17 (PARK17). PARK17 is an autosomal dominant, adult- onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. Belongs to the VPS35 family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 16q12

Cellular Component: cytosol; early endosome; endosome; late endosome; lysosomal membrane; retromer complex

Molecular Function: protein binding; protein transporter activity

Biological Process: intracellular protein transport; regulation of macroautophagy; regulation of protein stability; retrograde transport, endosome to Golgi; transcytosis; Wnt receptor signaling pathway

Disease: Parkinson Disease 17
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 Research Articles on VPS35    1. neither the R120W nor the N370S variant of the GBA gene nor D620N mutation of the VPS35 gene were detected among the Parkinson disease cases or the controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VPS35 peptidePathways associated with VPS35 peptide
 Reference Product  PubMed Publications
 VPS29 peptide  >62 publications with VPS35 and VPS29
 VPS26A peptide  >28 publications with VPS35 and VPS26A
 SNX1 peptide  >23 publications with VPS35 and SNX1
 SNX2 peptide  >10 publications with VPS35 and SNX2
 VPS26B peptide  >9 publications with VPS35 and VPS26B
 SORL1 peptide  >6 publications with VPS35 and SORL1
 SNX3 peptide  >5 publications with VPS35 and SNX3
 VPS36 peptide  >1 publications with VPS35 and VPS36
 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 WNT Ligand Biogenesis And Trafficking Pathway antibodies  WNT Ligand Biogenesis And Trafficking Pathway Diagram
Diseases associated with VPS35 peptideOrgans/Tissues associated with VPS35 peptide
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >68 publications with VPS35 and Neurodegenerative Diseases
 Parkinson Disease Antibodies  >62 publications with VPS35 and Parkinson Disease
 Nerve Degeneration Antibodies  >3 publications with VPS35 and Nerve Degeneration
 Kidney Diseases Antibodies  >3 publications with VPS35 and Kidney Diseases
 Adenocarcinoma Antibodies  >2 publications with VPS35 and Adenocarcinoma
 Congenital Abnormalities Antibodies  >1 publications with VPS35 and Congenital Abnormalities
 Lung Neoplasms Antibodies  >1 publications with VPS35 and Lung Neoplasms
 Hepatitis Antibodies  >1 publications with VPS35 and Hepatitis
 Anemia Antibodies  >1 publications with VPS35 and Anemia
 Cognition Disorders Antibodies  >1 publications with VPS35 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with VPS35 and Brain
 Nerve Antibodies  >6 publications with VPS35 and Nerve
 Kidney Antibodies  >5 publications with VPS35 and Kidney
 Eye Antibodies  >5 publications with VPS35 and Eye
 Heart Antibodies  >4 publications with VPS35 and Heart
 Liver Antibodies  >3 publications with VPS35 and Liver
 Intestine Antibodies  >3 publications with VPS35 and Intestine
 Ganglia Antibodies  >3 publications with VPS35 and Ganglia
 Muscle Antibodies  >3 publications with VPS35 and Muscle
 Blood Antibodies  >3 publications with VPS35 and Blood
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