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WASL peptide :: WASP / N-WASP Peptide

Scan QR to view Datasheet Catalog #    MBS474069 WASL peptide
Unit / Price
0.05 mg  /  $130 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WASP / N-WASP Peptide (WASL), Peptide

 Also Known As   

WASP / N-WASP Blocking Peptide

 Product Synonym Names    WASP / N-WASP Peptide
 Product Gene Name   

WASL peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Peptide Sequence: WASP / N-WASP synthetic peptide correspond s to a region near the C-terminus of human WASP. This sequence is highly homologous with a similar region in human N-WASP.
 Chromosome Location    Chromosome: 7; NC_000007.13 (123321997..123389116, complement). Location: 7q31.3
 OMIM    605056
 3D Structure    ModBase 3D Structure for O00401
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 Specificity    The peptide is specifically recognized by anti-WASP/N-WASP antibody (WP2101) in ELISA, and has been shown to block the reactivity of WP2101 during Western blot. In addition, the peptide is recommended for use in blocking WP2101 reactivity in immunocytochemistry.
 Form/Format    Blocking Peptide is supplied in 50ul phosphate-buffered saline and 0.05% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Stable for 1 year.
 Other Notes    Small volumes of WASL peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for WASL peptide

   Members of the Wiskott-Aldrich sydrome protein (WASP) family regulate the formation of actin-based cell structures in many cell types. These proteins contain C-terminal actin-binding domains that can stimulate actin polymerization. In addition, these proteins bind the ARP2/3 complex, which can nucleate actin polymerization at sites that lead to branched actin structures. WASP is expressed primarily in hematopoietic cells, while its homolog N-WASP is widely expressed. These proteins have 48% identity in human with the highest homology in the functional regions of these proteins. Serine and tyrosine phosphorylation regulates the activity of both proteins. WASP is observed as a 63 kDa protein in hematopoietic cells, while N-WASP is observed as a 65 kDa in many tissues, especially brain.
 Application Notes for WASL peptide    Antibody Blocking: 1 ug/ml
ELISA: 10-100 ng/well
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NCBI/Uniprot data below describe general gene information for WASL. It may not necessarily be applicable to this product.
 NCBI GI #    51702526
 NCBI GeneID    8976
 NCBI Accession #    NP_003932.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003941.2 [Other Products]
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 UniProt Primary Accession #    O00401 [Other Products]
 UniProt Secondary Accession #    Q7Z746 [Other Products]
 UniProt Related Accession #    O00401; Q68DE4 [Other Products]
 Molecular Weight    54696 Da [Similar Products]
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 NCBI Official Full Name    neural Wiskott-Aldrich syndrome protein
 NCBI Official Synonym Full Names    Wiskott-Aldrich syndrome-like
 NCBI Official Symbol    WASL [Similar Products]
 NCBI Official Synonym Symbols   
NWASP; N-WASP; MGC48327; DKFZp779G0847
[Similar Products]
 NCBI Protein Information    neural Wiskott-Aldrich syndrome protein; OTTHUMP00000211994; Wiskott-Aldrich syndrome gene-like
 UniProt Protein Name    Neural Wiskott-Aldrich syndrome protein
 Protein Family    Neural Wiskott-Aldrich syndrome protein
 UniProt Gene Name    WASL [Similar Products]
 UniProt Entry Name    WASL_HUMAN
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 NCBI Summary for WASL    The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq]
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 UniProt Comments for WASL    Function: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Ref.11

Subunit structure: Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11

By similarity. Interacts with NOSTRIN. Interacts with Shigella flexneri protein icsA. The interaction with icsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly. Interacts with E.coli EspF-like protein encoded on prophage U. Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF-like protein encoded on prophage U. Ref.4 Ref.5 Ref.6 Ref.11

Subcellular location: Cytoplasm › cytoskeleton

By similarity. Nucleus

By similarity. Note: Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated

Sequence similarities: Contains 1 CRIB domain.Contains 1 WH1 domain.Contains 2 WH2 domains.
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Product References and Citations for WASL peptide

   • Cory, G.O. et al. (2003) Mol Cell. 11(5):1229-39.
• Higgs, H.N. & Pollard, T.D. (2001) Annu Rev Biochem 70:649-676.
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 Research Articles on WASL    1. Recruitment of FAK and N-WASP is necessary for cell migration and invasion induced by 17beta-estradiol in breast cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with WASL peptidePathways associated with WASL peptide
 Reference Product  PubMed Publications
 src peptide  >30 publications with WASL and src
 FNBP1L peptide  >3 publications with WASL and FNBP1L
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 DCC Mediated Attractive Signaling Pathway antibodies  DCC Mediated Attractive Signaling Pathway Diagram
 EGF Receptor (ErbB1) Signaling Pathway antibodies  EGF Receptor (ErbB1) Signaling Pathway Diagram
Diseases associated with WASL peptideOrgans/Tissues associated with WASL peptide
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >25 publications with WASL and Neoplasms
 Blood Coagulation Disorders Antibodies  >22 publications with WASL and Blood Coagulation Disorders
 Skin Diseases Antibodies  >12 publications with WASL and Skin Diseases
 Breast Neoplasms Antibodies  >10 publications with WASL and Breast Neoplasms
 Carcinoma Antibodies  >8 publications with WASL and Carcinoma
 Neoplasm Invasiveness Antibodies  >7 publications with WASL and Neoplasm Invasiveness
 Gastrointestinal Neoplasms Antibodies  >6 publications with WASL and Gastrointestinal Neoplasms
 Neuroectodermal Tumors Antibodies  >5 publications with WASL and Neuroectodermal Tumors
 Neoplasm Metastasis Antibodies  >5 publications with WASL and Neoplasm Metastasis
 Vascular Diseases Antibodies  >4 publications with WASL and Vascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >4 publications with WASL and Heart
 Testis Antibodies  >3 publications with WASL and Testis
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