NP_001020107.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
wiskott-Aldrich syndrome protein family member 1
NCBI Official Synonym Full Names
WAS protein family, member 1
NCBI Official Synonym Symbols
WAVE; SCAR1; WAVE1; FLJ31482; KIAA0269 [Similar Products]
NCBI Protein Information
wiskott-Aldrich syndrome protein family member 1; protein WAVE-1; OTTHUMP00000016990; OTTHUMP00000016992; WASP family protein member 1; homology of dictyostelium scar 1; verprolin homology domain-containing protein 1
UniProt Protein Name
Wiskott-Aldrich syndrome protein family member 1
UniProt Synonym Protein Names
Protein WAVE-1; Verprolin homology domain-containing protein 1
UniProt Synonym Gene Names
UniProt Entry Name
WASF1_HUMAN
NCBI Summary for WASF1
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
UniProt Comments for WASF1
Function: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subunit structure: Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1
By similarity. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Ref.7 Ref.8
Subcellular location: Cytoplasm › cytoskeleton. Note: Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
Tissue specificity: Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
Domain: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
Sequence similarities: Belongs to the SCAR/WAVE family.Contains 1 WH2 domain.
Sequence caution: The sequence BAA13399.2 differs from that shown. Reason: Erroneous initiation.
Product References and Citations for WASF1 peptide
• Ardern, H. et al. (2006) Cell Motil. Cytosk. 63:6. • Leng, Y. et al. (2005) PNAS 102(4):1098. • Suetsugu, S. et al. (1999) Bioch. Biophs. Res. Comm. 260:296. • Miki, H. et al. (1999) J Biol. Chem. 274(39):27605.
Research Articles on WASF1
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Products associated with WASF1 peptide
Pathways associated with WASF1 peptide
Diseases associated with WASF1 peptide
Organs/Tissues associated with WASF1 peptide
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