NP_064520.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,339 Da
NCBI Official Full Name
ATPase WRNIP1 isoform 1
NCBI Official Synonym Full Names
Werner helicase interacting protein 1
NCBI Protein Information
ATPase WRNIP1
UniProt Protein Name
ATPase WRNIP1
UniProt Synonym Protein Names
Werner helicase-interacting protein 1
UniProt Entry Name
WRIP1_HUMAN
NCBI Summary for WRNIP1
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for WRNIP1
WRNIP1: a modulator for initiation or restart of DNA polymerase delta-mediated DNA synthesis. Its ATPase activity may sense DNA ends and regulate the extent of polymerase stimulation.
Protein type: EC 3.6.1.3; Helicase
Chromosomal Location of Human Ortholog: 6p25.2
Cellular Component: membrane; nuclear chromosome, telomeric region; nucleus; perinuclear region of cytoplasm
Molecular Function: ATP binding; ATPase activity; DNA binding; identical protein binding; metal ion binding; protein binding
Biological Process: DNA replication; DNA synthesis during DNA repair; regulation of DNA replication initiation
Research Articles on WRNIP1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with WRNIP1 blocking peptide
Diseases associated with WRNIP1 blocking peptide
Organs/Tissues associated with WRNIP1 blocking peptide
|