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WHSC1 peptide :: WHSC1 / MMSET Peptide

Scan QR to view Datasheet Catalog #    MBS425083 WHSC1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WHSC1 / MMSET, Peptide

 Also Known As   

WHSC1 / MMSET Immunizing Peptide

 Product Synonym Names    WHSC1 antibody; Wolf-Hirschhorn syndrome candidate 1 antibody; NSD2 antibody; TRX5 antibody; MMSET antibody; REIIBP antibody; KIAA1090 antibody; trithorax/ash1-related protein 5 antibody; multiple myeloma SET domain protein antibody; IL-5 promoter REII-region-binding protein antibody; FLJ23286 antibody; MGC176638 antibody; OTTHUMP00000196943 antibody; Wolf-Hirschhorn syndrome candidate 1 protein antibody; multiple myeloma SET domain containing protein type III antibody
 Product Gene Name   

WHSC1 peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    EFSIKQSPLS VQS-C
 Chromosome Location    Chromosome: 4; NC_000004.11 (1873123..1983934). Location: 4p16.3
 OMIM    602952
 3D Structure    ModBase 3D Structure for O96028
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Corresponding Antibody    The peptide was used in the production of MBS421196 - Goat Anti-WHSC1 / MMSET Antibody.
It is currently untested in blocking applications.
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of WHSC1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for WHSC1. It may not necessarily be applicable to this product.
 NCBI GI #    109633019
 NCBI GeneID    7468
 NCBI Accession #    NP_001035889.1 [Other Products]
 NCBI Related Accession #    NP_579877.1; NP_579878.1; NP_579890.1; NP_579889.1; NP_015627.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042424.2 [Other Products]
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 UniProt Primary Accession #    O96028 [Other Products]
 UniProt Secondary Accession #    O96031; Q4VBY8; Q672J1; Q6IS00; Q86V01; Q9BZB4; A2A2T2; A2A2T3; A2A2T4; A7MCZ1; D3DVQ2 [Other Products]
 UniProt Related Accession #    O96028 [Other Products]
 Molecular Weight    152,258 Da
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 NCBI Official Full Name    histone-lysine N-methyltransferase NSD2 isoform 1
 NCBI Official Synonym Full Names    Wolf-Hirschhorn syndrome candidate 1
 NCBI Official Symbol    WHSC1 [Similar Products]
 NCBI Official Synonym Symbols   
WHS; NSD2; TRX5; MMSET; REIIBP
[Similar Products]
 NCBI Protein Information    histone-lysine N-methyltransferase NSD2; trithorax/ash1-related protein 5; nuclear SET domain-containing protein 2; IL5 promoter REII region-binding protein; probable histone-lysine N-methyltransferase NSD2; multiple myeloma SET domain containing protein type III
 UniProt Protein Name    Histone-lysine N-methyltransferase NSD2
 UniProt Synonym Protein Names   
Multiple myeloma SET domain-containing protein; MMSET; Nuclear SET domain-containing protein 2; NSD2; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein
 Protein Family    Histone-lysine N-methyltransferase
 UniProt Gene Name    WHSC1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1090; MMSET; NSD2; TRX5; MMSET; NSD2; WHSC1 [Similar Products]
 UniProt Entry Name    NSD2_HUMAN
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 NCBI Summary for WHSC1    This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WHSC1    Function: Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. Ref.4 Ref.16 Ref.20

Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. Ref.20

Subcellular location: Nucleus. Chromosome

Potential Ref.5 Ref.17. Isoform 4: Cytoplasm Ref.5 Ref.17.

Tissue specificity: Widely expressed. Ref.2

Involvement in disease: A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH.WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems. Ref.18

Sequence similarities: Belongs to the histone-lysine methyltransferase family. SET2 subfamily.Contains 1 AWS domain.Contains 1 HMG box DNA-binding domain.Contains 4 PHD-type zinc fingers.Contains 1 post-SET domain.Contains 2 PWWP domains.Contains 1 SET domain.

Sequence caution: The sequence BAA83042.2 differs from that shown. Reason: Erroneous initiation.
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 Research Articles on WHSC1    1. Overexpression of the histone methyltransferase MMSET is associated with myeloma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with WHSC1 peptideDiseases associated with WHSC1 peptide
 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >43 publications with WHSC1 and Neoplasms
 Cardiovascular Diseases Antibodies  >30 publications with WHSC1 and Cardiovascular Diseases
 Wolf-Hirschhorn Syndrome Antibodies  >29 publications with WHSC1 and Wolf-Hirschhorn Syndrome
 Congenital Abnormalities Antibodies  >17 publications with WHSC1 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >17 publications with WHSC1 and Abnormalities, Multiple
 Cell Transformation, Neoplastic Antibodies  >6 publications with WHSC1 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >6 publications with WHSC1 and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >5 publications with WHSC1 and Craniofacial Abnormalities
 Neurobehavioral Manifestations Antibodies  >4 publications with WHSC1 and Neurobehavioral Manifestations
 Necrosis Antibodies  >3 publications with WHSC1 and Necrosis
Organs/Tissues associated with WHSC1 peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with WHSC1 and Blood
 Bone Antibodies  >7 publications with WHSC1 and Bone
 Brain Antibodies  >4 publications with WHSC1 and Brain
 Prostate Antibodies  >3 publications with WHSC1 and Prostate
 Vascular Antibodies  >3 publications with WHSC1 and Vascular
 Lung Antibodies  >3 publications with WHSC1 and Lung
 Embryonic Tissue Antibodies  >3 publications with WHSC1 and Embryonic Tissue
 Bone Marrow Antibodies  >3 publications with WHSC1 and Bone Marrow
 Testis Antibodies  >2 publications with WHSC1 and Testis
 Bladder Antibodies  >2 publications with WHSC1 and Bladder
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