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WISP1 peptide

Scan QR to view Datasheet Catalog #    MBS426152 WISP1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WISP1, Peptide

 Also Known As   

WISP1 Immunizing Peptide

 Product Synonym Names    WISP1; WNT1 inducible signaling pathway protein 1; CCN4; WISP1c; WISP1i; WISP1tc; WNT1 induced secreted protein 1; Wnt-1 inducible signaling pathway protein 1; wnt-1 signaling pathway protein 1
 Product Gene Name   

WISP1 peptide

[Similar Products]
 Antibody/Peptide Pairs    WISP1 peptide (MBS426152) is used for blocking the activity of WISP1 antibody (MBS421320)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-ESYPDFSE IAN
 OMIM    603398
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 Species Reactivity    Human, Mouse, Rat,
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of WISP1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for WISP1. It may not necessarily be applicable to this product.
 NCBI GI #    4507921
 NCBI GeneID    8840
 NCBI Accession #    NP_003873.1 [Other Products]
 NCBI Related Accession #    NP_543028.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003882.3 [Other Products]
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 UniProt Secondary Accession #    Q5JBS6; Q5JBS7; Q5JBS8; Q9HCS3; A8KAG6; E7EMM5 [Other Products]
 UniProt Related Accession #    O95388 [Other Products]
 Molecular Weight    21,550 Da
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 NCBI Official Full Name    WNT1-inducible-signaling pathway protein 1 isoform 1
 NCBI Official Synonym Full Names    WNT1 inducible signaling pathway protein 1
 NCBI Official Symbol    WISP1 [Similar Products]
 NCBI Official Synonym Symbols   
CCN4; WISP1c; WISP1i; WISP1tc
[Similar Products]
 NCBI Protein Information    WNT1-inducible-signaling pathway protein 1
 UniProt Protein Name    WNT1-inducible-signaling pathway protein 1
 UniProt Synonym Protein Names   
CCN family member 4; Wnt-1-induced secreted protein
 Protein Family    WNT1-inducible-signaling pathway protein
 UniProt Gene Name    WISP1 [Similar Products]
 UniProt Synonym Gene Names    CCN4; WISP-1 [Similar Products]
 UniProt Entry Name    WISP1_HUMAN
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 NCBI Summary for WISP1    This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
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 UniProt Comments for WISP1    WISP1: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. Belongs to the CCN family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q24.22

Cellular Component: cytoplasm; proteinaceous extracellular matrix

Molecular Function: heparin binding; integrin binding

Biological Process: cell adhesion; cell-cell signaling; signal transduction
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 Research Articles on WISP1    1. Its role in tumor progression and clinical outcome makes WISP1 an emerging candidate for the detection and treatment of tumors. [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with WISP1 peptideOrgans/Tissues associated with WISP1 peptide
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >30 publications with WISP1 and Carcinoma
 Inflammation Antibodies  >18 publications with WISP1 and Inflammation
 Lung Diseases Antibodies  >18 publications with WISP1 and Lung Diseases
 Fibrosis Antibodies  >16 publications with WISP1 and Fibrosis
 Disease Models, Animal Antibodies  >14 publications with WISP1 and Disease Models, Animal
 Breast Neoplasms Antibodies  >13 publications with WISP1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >11 publications with WISP1 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >11 publications with WISP1 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >10 publications with WISP1 and Cell Transformation, Neoplastic
 Hypertrophy Antibodies  >9 publications with WISP1 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >37 publications with WISP1 and Connective Tissue
 Bone Antibodies  >34 publications with WISP1 and Bone
 Lung Antibodies  >23 publications with WISP1 and Lung
 Muscle Antibodies  >15 publications with WISP1 and Muscle
 Embryonic Tissue Antibodies  >13 publications with WISP1 and Embryonic Tissue
 Liver Antibodies  >13 publications with WISP1 and Liver
 Brain Antibodies  >8 publications with WISP1 and Brain
 Intestine Antibodies  >4 publications with WISP1 and Intestine
 Adipose Tissue Antibodies  >4 publications with WISP1 and Adipose Tissue
 Pancreas Antibodies  >3 publications with WISP1 and Pancreas
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