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YAP1 peptide

Scan QR to view Datasheet Catalog #    MBS427988 YAP1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

YAP1, Peptide

 Also Known As   

YAP1 Immunizing Peptide

 Product Synonym Names    Goat Anti-YAP / YAP1 Antibody; Yes-associated protein 1; 65kDa antibody; YAP antibody; YAP2 antibody; YAP65 antibody; Yes-associated protein 1; 65 kD antibody; Yes-associated protein 1; 65 kDa antibody; yes-associated protein 2 antibody
 Product Gene Name   

YAP1 peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-NQSTLPSQ QNRFPD
 Chromosome Location    Chromosome: 11; NC_000011.9 (101981192..102104154). Location: 11q13
 OMIM    606608
 3D Structure    ModBase 3D Structure for P46937
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 Species Reactivity    Tested: Dog
Expected: Human, Mouse, Rat
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 Form/Format    100ug of dried peptide
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 Corresponding Antibody    The peptide was used in the production of MBS422985 -
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of YAP1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for YAP1. It may not necessarily be applicable to this product.
 NCBI GI #    5174751
 NCBI GeneID    10413
 NCBI Accession #    NP_006097.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006106.3 [Other Products]
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 UniProt Primary Accession #    P46937 [Other Products]
 UniProt Secondary Accession #    Q7Z574; Q8IUY9; B4DTY1 [Other Products]
 UniProt Related Accession #    P46937 [Other Products]
 Molecular Weight    54,462 Da
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 NCBI Official Full Name    yorkie homolog isoform 2
 NCBI Official Synonym Full Names    Yes-associated protein 1
 NCBI Official Symbol    YAP1 [Similar Products]
 NCBI Official Synonym Symbols   
YAP; YKI; YAP2; YAP65
[Similar Products]
 NCBI Protein Information    yorkie homolog; yes-associated protein 2; yes-associated protein beta; yes-associated protein delta; 65 kDa Yes-associated protein
 UniProt Protein Name    Yorkie homolog
 UniProt Synonym Protein Names   
65 kDa Yes-associated protein
 Protein Family    YAP1-binding protein
 UniProt Gene Name    YAP1 [Similar Products]
 UniProt Synonym Gene Names    YAP65; YAP65 [Similar Products]
 UniProt Entry Name    YAP1_HUMAN
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 NCBI Summary for YAP1    This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq, Jul 2008]
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 UniProt Comments for YAP1    Function: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3). Ref.2 Ref.11 Ref.13 Ref.14 Ref.15 Ref.18

Subunit structure: Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif

By similarity. The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Isoform 2 and isoform 3 interact (via WW domain 1) with isoform 3 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4. Interacts with TP73. Interacts with RUNX1. Interacts with HCK. Interacts (via WW domains) with PTPN14 (via PPxY motif 2); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional coactivator activity. Ref.2 Ref.7 Ref.10 Ref.11 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21 Ref.25

Subcellular location: Cytoplasm. Nucleus. Note: Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density. PTPN14 induces translocation from the nucleus to the cytoplasm. Ref.11 Ref.14 Ref.15 Ref.19 Ref.25

Tissue specificity: Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level). Ref.1 Ref.9 Ref.11

Post-translational modification: Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1; leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes; in response to DNA damage. Phosphorylation at Ser-400 and Ser-403 by CK1 is triggered by previous phosphorylation at Ser-397 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation. Phosphorylated at Thr-119, Ser-138, Thr-154, Ser-367 and Thr-412 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regukation of apoptosis by YAP1. Ref.11 Ref.14 Ref.15 Ref.18 Ref.19Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase. Ref.19

Sequence similarities: Belongs to the YORKIE family.Contains 2 WW domains.
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 Research Articles on YAP1    1. YAP-1 partially shares basal characters with mammalian YAP and plays a role in thermal stress response and healthy aging.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with YAP1 peptidePathways associated with YAP1 peptide
 Reference Product  PubMed Publications
 TEAD1 peptide  >8 publications with YAP1 and TEAD1
 RUNX2 peptide  >4 publications with YAP1 and RUNX2
 TEAD4 peptide  >3 publications with YAP1 and TEAD4
 WBP1 peptide  >3 publications with YAP1 and WBP1
 TP53BP2 peptide  >3 publications with YAP1 and TP53BP2
 TEAD2 peptide  >2 publications with YAP1 and TEAD2
 RUNX1 peptide  >2 publications with YAP1 and RUNX1
 ERBB4 peptide  >2 publications with YAP1 and ERBB4
 WBP2 peptide  >2 publications with YAP1 and WBP2
 TEAD3 peptide  >1 publications with YAP1 and TEAD3
 Products by Pathway  Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
Diseases associated with YAP1 peptideOrgans/Tissues associated with YAP1 peptide
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >63 publications with YAP1 and Neoplasms
 Drug Toxicity Antibodies  >29 publications with YAP1 and Drug Toxicity
 Cell Transformation, Neoplastic Antibodies  >12 publications with YAP1 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >9 publications with YAP1 and Disease Models, Animal
 Carcinoma, Squamous Cell Antibodies  >9 publications with YAP1 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >9 publications with YAP1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with YAP1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >8 publications with YAP1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >8 publications with YAP1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >7 publications with YAP1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >14 publications with YAP1 and Lung
 Brain Antibodies  >10 publications with YAP1 and Brain
 Muscle Antibodies  >10 publications with YAP1 and Muscle
 Intestine Antibodies  >7 publications with YAP1 and Intestine
 Liver Antibodies  >7 publications with YAP1 and Liver
 Vascular Antibodies  >6 publications with YAP1 and Vascular
 Skin Antibodies  >6 publications with YAP1 and Skin
 Stomach Antibodies  >5 publications with YAP1 and Stomach
 Ovary Antibodies  >5 publications with YAP1 and Ovary
 Bone Antibodies  >5 publications with YAP1 and Bone
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