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LDB3 peptide :: ZASP/ CYPHER / LDB3 Peptide

Scan QR to view Datasheet Catalog #    MBS426343 LDB3 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZASP/ CYPHER / LDB3, Peptide

 Also Known As   

ZASP/ CYPHER / LDB3 Immunizing Peptide

 Product Synonym Names    LDB3; ZASP; LIM domain binding 3; HGNC: 15710; KIAA01613; KIAA0613; ORACLE; PDLIM6; PDZ and LIM domain 6; Z-band alternatively spliced PDZ-motif; CYPHER; FLJ35865; ldb3z1; ldb3z4; ZASP/ CYPHER / LDB3
 Product Gene Name   

LDB3 peptide

[Similar Products]
 Product Synonym Gene Name    ZASP; CYPHER [Similar Products]
 Antibody/Peptide Pairs    ZASP/ CYPHER / LDB3 peptide (MBS426343) is used for blocking the activity of ZASP/ CYPHER/LDB3 antibody (MBS421324)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-KSQNKPED EADE
 OMIM    601493
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 Species Reactivity    Human, Mouse, Rat, Dog, Pig
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of LDB3 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for LDB3. It may not necessarily be applicable to this product.
 NCBI GI #    45592959
 NCBI GeneID    11155
 NCBI Accession #    NP_009009.1 [Other Products]
 NCBI Related Accession #    NP_001073583.1; NP_001073584.1; NP_001073585.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007078.2 [Other Products]
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 UniProt Secondary Accession #    Q5K6N9; Q5K6P0; Q5K6P1; Q96FH2; Q9Y4Z3; Q9Y4Z4; Q9Y4Z5; A2TDB7; A6NIV4; B4E3K3 [Other Products]
 UniProt Related Accession #    O75112 [Other Products]
 Molecular Weight    78,504 Da
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 NCBI Official Full Name    LIM domain-binding protein 3 isoform 1
 NCBI Official Synonym Full Names    LIM domain binding 3
 NCBI Official Symbol    LDB3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    LIM domain-binding protein 3
 UniProt Protein Name    LIM domain-binding protein 3
 UniProt Synonym Protein Names   
Protein cypher; Z-band alternatively spliced PDZ-motif protein
 Protein Family    LIM domain-binding protein
 UniProt Gene Name    LDB3 [Similar Products]
 UniProt Entry Name    LDB3_HUMAN
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 NCBI Summary for LDB3    This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]
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 UniProt Comments for LDB3    LDB3: May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. Defects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in LDB3 are the cause of left ventricular non- compaction type 3 (LVNC3). Left ventricular non- compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle. Defects in LDB3 are the cause of myopathy myofibrillar type 4 (MFM4). A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 10q22.3-q23.2

Cellular Component: cytoskeleton; Z disc

Molecular Function: cytoskeletal protein binding; protein binding

Disease: Myopathy, Myofibrillar, 4
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 Research Articles on LDB3    1. this is the first family with Arrhythmogenic right ventricular cardiomyopathy where a mutation in LDB3 is associated with Arrhythmogenic right ventricular cardiomyopathy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with LDB3 peptideOrgans/Tissues associated with LDB3 peptide
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >39 publications with LDB3 and Heart Diseases
 Cardiomegaly Antibodies  >20 publications with LDB3 and Cardiomegaly
 Hypertrophy Antibodies  >7 publications with LDB3 and Hypertrophy
 Disease Models, Animal Antibodies  >7 publications with LDB3 and Disease Models, Animal
 Abnormalities, Multiple Antibodies  >6 publications with LDB3 and Abnormalities, Multiple
 Fibrosis Antibodies  >4 publications with LDB3 and Fibrosis
 Atrophy Antibodies  >4 publications with LDB3 and Atrophy
 Necrosis Antibodies  >3 publications with LDB3 and Necrosis
 MYOPATHY, MYOFIBRILLAR, 4 Antibodies  >3 publications with LDB3 and MYOPATHY, MYOFIBRILLAR, 4
 Kidney Diseases Antibodies  >1 publications with LDB3 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >64 publications with LDB3 and Muscle
 Heart Antibodies  >36 publications with LDB3 and Heart
 Nerve Antibodies  >4 publications with LDB3 and Nerve
 Brain Antibodies  >4 publications with LDB3 and Brain
 Embryonic Tissue Antibodies  >3 publications with LDB3 and Embryonic Tissue
 Kidney Antibodies  >2 publications with LDB3 and Kidney
 Eye Antibodies  >1 publications with LDB3 and Eye
 Lung Antibodies  >1 publications with LDB3 and Lung
 Vascular Antibodies  >1 publications with LDB3 and Vascular
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