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TJP1 peptide :: ZO-1 Peptide

Scan QR to view Datasheet Catalog #    MBS425102 TJP1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZO-1 (TJP1), Peptide

★Popular Item★
 Also Known As   

ZO-1 Immunizing Peptide

 Product Synonym Names    TJP1; tight junction protein 1 (zona occludens 1); DKFZp686M05161; MGC133289; ZO-1; OTTHUMP00000174520; tight junction protein 1; tight junction protein ZO-1; zona occludens 1; zonula occludens 1 protein
 Product Gene Name   

TJP1 peptide

[Similar Products]
 Product Synonym Gene Name    ZO-1 [Similar Products]
 Antibody/Peptide Pairs    ZO-1 peptide (MBS425102) is used for blocking the activity of ZO-1 antibody (MBS422103)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-PKPTSQNQ FSEHDKT
 OMIM    601009
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 Form/Format    100 ug of Lyophilized peptide, formulation 5pmol,uL in 5% (v/v)acetonitrile/H20. Reconstitute pellet in distilled water where required. For blocking studies, reconstitute pellet in 200 uL distilled water to obtain a 0.5 mg/mL peptide solution.
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 Preparation and Storage    Shipped at ambient temperature, store at -20C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of TJP1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TJP1 peptide

   The peptide was used in the production of MBS422103- Goat Anti-ZO-1 Antibody. It is currently untested in blocking applications.
NCBI/Uniprot data below describe general gene information for TJP1. It may not necessarily be applicable to this product.
 NCBI GI #    116875767
 NCBI GeneID    7082
 NCBI Accession #    NP_003248.3 [Other Products]
 NCBI Related Accession #    NP_783297.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003257.4 [Other Products]
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 UniProt Secondary Accession #    Q2NKP3; Q4ZGJ6; B4E3K1 [Other Products]
 UniProt Related Accession #    Q07157 [Other Products]
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 NCBI Official Full Name    tight junction protein ZO-1 isoform a
 NCBI Official Synonym Full Names    tight junction protein 1
 NCBI Official Symbol    TJP1 [Similar Products]
 NCBI Official Synonym Symbols   
ZO-1
[Similar Products]
 NCBI Protein Information    tight junction protein ZO-1
 UniProt Protein Name    Tight junction protein ZO-1
 UniProt Synonym Protein Names   
Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1
 Protein Family    Tight junction protein
 UniProt Gene Name    TJP1 [Similar Products]
 UniProt Synonym Gene Names    ZO1 [Similar Products]
 UniProt Entry Name    ZO1_HUMAN
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 NCBI Summary for TJP1    This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for TJP1    ZO1: a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with tight junctions (TJ). May mediate dynamic changes in the composition of TJs. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting the protein kinase MRCKb to the leading edge of migrating cells. Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1. Forms homodimers and heterodimers with ZO-2 or ZO-3. Interacts with occludin, CALM, claudins, CGN, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with MRCKb and MYZAP. Interacts (via PDZ domain) with Cx43. ZO-2 and ZO-3 shuttle between the TJ and the nucleus, where they may regulate gene expression. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins can be up- or downregulated in cancer and are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Alternative splicing produces two isoforms. The long isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 15q13

Cellular Component: apical junction complex; apical part of cell; apical plasma membrane; apicolateral plasma membrane; basolateral plasma membrane; cell junction; cell-cell adherens junction; cytoplasm; cytosol; gap junction; intercellular canaliculus; nucleus; plasma membrane; tight junction

Molecular Function: calmodulin binding; protein binding; protein domain specific binding

Biological Process: blastocyst formation; intercellular junction assembly; sensory perception of sound
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 Research Articles on TJP1    1. Report TNF-alpha/Il6 mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TJP1 peptidePathways associated with TJP1 peptide
 Reference Product  PubMed Publications
 OCLN peptide  >553 publications with TJP1 and OCLN
 TJP2 peptide  >94 publications with TJP1 and TJP2
 CLDN2 peptide  >26 publications with TJP1 and CLDN2
 GJA1 peptide  >18 publications with TJP1 and GJA1
 CGN peptide  >16 publications with TJP1 and CGN
 CDH1 peptide  >13 publications with TJP1 and CDH1
 CSDA peptide  >10 publications with TJP1 and CSDA
 MLLT4 peptide  >10 publications with TJP1 and MLLT4
 CTTN peptide  >5 publications with TJP1 and CTTN
 KIRREL peptide  >4 publications with TJP1 and KIRREL
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 E-cadherin Signaling In The Nascent Adherens Junction Pathway antibodies  E-cadherin Signaling In The Nascent Adherens Junction Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
Diseases associated with TJP1 peptideOrgans/Tissues associated with TJP1 peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >171 publications with TJP1 and Inflammation
 Disease Models, Animal Antibodies  >155 publications with TJP1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >139 publications with TJP1 and Nervous System Diseases
 Brain Diseases Antibodies  >122 publications with TJP1 and Brain Diseases
 Necrosis Antibodies  >112 publications with TJP1 and Necrosis
 Cardiovascular Diseases Antibodies  >96 publications with TJP1 and Cardiovascular Diseases
 Edema Antibodies  >56 publications with TJP1 and Edema
 Kidney Diseases Antibodies  >49 publications with TJP1 and Kidney Diseases
 Lung Diseases Antibodies  >45 publications with TJP1 and Lung Diseases
 Liver Diseases Antibodies  >37 publications with TJP1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >468 publications with TJP1 and Blood
 Vascular Antibodies  >296 publications with TJP1 and Vascular
 Brain Antibodies  >292 publications with TJP1 and Brain
 Intestine Antibodies  >235 publications with TJP1 and Intestine
 Eye Antibodies  >221 publications with TJP1 and Eye
 Kidney Antibodies  >186 publications with TJP1 and Kidney
 Liver Antibodies  >125 publications with TJP1 and Liver
 Embryonic Tissue Antibodies  >91 publications with TJP1 and Embryonic Tissue
 Muscle Antibodies  >91 publications with TJP1 and Muscle
 Nerve Antibodies  >86 publications with TJP1 and Nerve
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