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CCND1 peptide :: cyclin D1 Peptide

Scan QR to view Datasheet Catalog #    MBS443014 CCND1 peptide
Unit / Price
0.1 mg  /  $125 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cyclin D1 (CCND1), Peptide

 Also Known As   

cyclin D1 (C20) Blocking Peptide

 Product Gene Name   

CCND1 peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    168461
 3D Structure    ModBase 3D Structure for P24385
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 Concentration    0.100 mg/0.5 ml (lot specific)
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of CCND1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for CCND1 peptide    Controls
NCBI/Uniprot data below describe general gene information for CCND1. It may not necessarily be applicable to this product.
 NCBI GI #    16950655
 NCBI GeneID    595
 NCBI Accession #    NP_444284.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053056.2 [Other Products]
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 UniProt Primary Accession #    P24385 [Other Products]
 UniProt Secondary Accession #    Q6LEF0 [Other Products]
 UniProt Related Accession #    P24385 [Other Products]
 Molecular Weight    33,729 Da [Similar Products]
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 NCBI Official Full Name    G1/S-specific cyclin-D1
 NCBI Official Synonym Full Names    cyclin D1
 NCBI Official Symbol    CCND1 [Similar Products]
 NCBI Official Synonym Symbols   
BCL1; PRAD1; U21B31; D11S287E
[Similar Products]
 NCBI Protein Information    G1/S-specific cyclin-D1; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL-1 oncogene; PRAD1 oncogene
 UniProt Protein Name    G1/S-specific cyclin-D1
 UniProt Synonym Protein Names   
B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene
 Protein Family    G1/S-specific cyclin
 UniProt Gene Name    CCND1 [Similar Products]
 UniProt Synonym Gene Names    BCL1; PRAD1; BCL-1 [Similar Products]
 UniProt Entry Name    CCND1_HUMAN
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 NCBI Summary for CCND1    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CCND1    CCND1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.

Protein type: Oncoprotein; Cell cycle regulation; Nuclear receptor co-regulator; Activator

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; tight junction; membrane; transcriptional repressor complex; cyclin-dependent protein kinase holoenzyme complex; intracellular; cytosol; nucleus

Molecular Function: protein binding; enzyme binding; histone deacetylase binding; protein complex binding; cyclin-dependent protein kinase regulator activity; protein kinase binding; transcription corepressor activity; transcription factor binding; protein kinase activity

Biological Process: G1 DNA damage checkpoint; fat cell differentiation; lactation; establishment and/or maintenance of chromatin architecture; positive regulation of cyclin-dependent protein kinase activity; negative regulation of Wnt receptor signaling pathway; re-entry into mitotic cell cycle; positive regulation of mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; response to magnesium ion; response to vitamin E; Leydig cell differentiation; response to iron ion; response to corticosterone stimulus; response to X-ray; response to drug; Notch signaling pathway; organ regeneration; transcription, DNA-dependent; unfolded protein response; mammary gland epithelial cell proliferation; response to organic nitrogen; liver development; response to ethanol; cell division; response to estrogen stimulus; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; response to calcium ion; response to DNA damage stimulus; G1/S transition of mitotic cell cycle

Disease: Von Hippel-lindau Syndrome; Myeloma, Multiple
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 Research Articles on CCND1    1. CCND1 G870A polymorphism may increase risk of non-Hodgkin lymphoma, but not leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CCND1 peptidePathways associated with CCND1 peptide
 Reference Product  PubMed Publications
 CDK4 peptide  >2114 publications with CCND1 and CDK4
 CDKN1A peptide  >1442 publications with CCND1 and CDKN1A
 CDK2 peptide  >1259 publications with CCND1 and CDK2
 CDKN1B peptide  >1123 publications with CCND1 and CDKN1B
 PCNA peptide  >974 publications with CCND1 and PCNA
 CDK6 peptide  >542 publications with CCND1 and CDK6
 STAT3 peptide  >527 publications with CCND1 and STAT3
 RB1 peptide  >110 publications with CCND1 and RB1
 ESR1 peptide  >31 publications with CCND1 and ESR1
 UBC peptide  >10 publications with CCND1 and UBC
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with CCND1 peptideOrgans/Tissues associated with CCND1 peptide
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4049 publications with CCND1 and Carcinoma
 Breast Neoplasms Antibodies  >1760 publications with CCND1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >909 publications with CCND1 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >861 publications with CCND1 and Cell Transformation, Neoplastic
 Colorectal Neoplasms Antibodies  >839 publications with CCND1 and Colorectal Neoplasms
 Leukemia Antibodies  >792 publications with CCND1 and Leukemia
 Lymphoma, Mantle-Cell Antibodies  >767 publications with CCND1 and Lymphoma, Mantle-Cell
 Liver Diseases Antibodies  >712 publications with CCND1 and Liver Diseases
 Liver Neoplasms Antibodies  >687 publications with CCND1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >680 publications with CCND1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1258 publications with CCND1 and Blood
 Liver Antibodies  >1228 publications with CCND1 and Liver
 Lung Antibodies  >1030 publications with CCND1 and Lung
 Vascular Antibodies  >1026 publications with CCND1 and Vascular
 Muscle Antibodies  >892 publications with CCND1 and Muscle
 Bone Antibodies  >782 publications with CCND1 and Bone
 Brain Antibodies  >676 publications with CCND1 and Brain
 Lymph Node Antibodies  >647 publications with CCND1 and Lymph Node
 Lymph Antibodies  >639 publications with CCND1 and Lymph
 Prostate Antibodies  >624 publications with CCND1 and Prostate
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