NP_001129205.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,244 Da
NCBI Official Full Name
tumor protein p53-inducible nuclear protein 1 isoform b
NCBI Official Synonym Full Names
tumor protein p53 inducible nuclear protein 1
NCBI Official Synonym Symbols
SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B [Similar Products]
NCBI Protein Information
tumor protein p53-inducible nuclear protein 1
UniProt Protein Name
Tumor protein p53-inducible nuclear protein 1
UniProt Synonym Protein Names
Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1
UniProt Synonym Gene Names
UniProt Entry Name
T53I1_HUMAN
UniProt Comments for p53DINP1
TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; Cell cycle regulation; Apoptosis
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: PML body; autophagic vacuole; cytoplasmic vesicle; cytosol; nucleus
Molecular Function: antioxidant activity; protein binding
Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; response to heat; apoptosis; positive regulation of transcription, DNA-dependent; autophagic cell death; response to stress; cell cycle arrest; negative regulation of cell migration; positive regulation of autophagy; autophagic vacuole formation
Research Articles on p53DINP1
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Products associated with p53DINP1 peptide
Pathways associated with p53DINP1 peptide
Diseases associated with p53DINP1 peptide
Organs/Tissues associated with p53DINP1 peptide
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