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F8 plasma :: Factor VIII Plasma

Scan QR to view Datasheet Catalog #    MBS514010 F8 plasma
Unit / Price
1 mL  /  $120 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Factor VIII (F8), Plasma

★Popular Item★
 Also Known As   

Factor VIII Deficient Plasma

 Product Gene Name   

F8 plasma

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS514010 MSDS    MSDS PDF
 OMIM    M14113 mRNA
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 Presentation    Frozen Factor VIII deficient plasma.
 Preparation/Handling    Thaw 1 ml vials in 37C waterbath for 5 minutes; for bulk volumes, thawing time will be dependent on bottle size.
 Specifications    Lot specific assay results;

Assay:
PT (Stago Neoplastine C1 +): 12.6 sec
APTT (HemoslL APTT-SP): 80.1 sec
Fibrinogen (clottable): 3.22 g/L
FII (activity): 1.09 U/ml
FV (activity): 1.00 U/ml
FVII (activity): 0.90 U/ml
FVIII (activity): <0.01 U/ml
FIX (activity): 1.06 U/ml
FX (activity): 1.08 U/ml
FXI (activity): 0.70 U/ml
FXII (activity): 1.14 U/ml
FVIII Inhibitor assay (1:1, 120 min @ 37 degree C): Negative
 Note    Although this material was prepared with plasma collected from donors screened for CJD and which was tested at source and found negative for HBsAg, syphilis and antibodies to HIV and HeV an.d non-reactilleJof HIV-1 r.NA and HCV rNA by FDA approved tests, it should be har:1dled by personnel trained in the proper procedures for handling potential viral contaminants.
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 Preparation and Storage    Plasma is shipped frozen and should be stored below -60C. Product is stable until date stated on vial label when stored at -60C. Once thawed, plasma is stable for 4 hours at 2-8C in original vial.
Shipping: Dry Ice
 Other Notes    Small volumes of F8 plasma vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for F8 plasma

   Pooled normal citrated human plasma depleted of Factor VIII using antibodies directed to Factor VIII immobilized on agarose beads. Plasma contains 20mM HEPES.
 Product Categories/Family for F8 plasma    Neutralizing Antibodies & Control IgG
NCBI/Uniprot data below describe general gene information for F8. It may not necessarily be applicable to this product.
 NCBI GI #    182803
 NCBI GeneID    2157
 NCBI Accession #    AAA52484.1 [Other Products]
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 UniProt Secondary Accession #    Q14286; Q5HY69 [Other Products]
 UniProt Related Accession #    P00451 [Other Products]
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 NCBI Official Full Name    factor VIII
 NCBI Official Synonym Full Names    coagulation factor VIII
 NCBI Official Symbol    F8 [Similar Products]
 NCBI Official Synonym Symbols   
AHF; F8B; F8C; HEMA; FVIII; DXS1253E
[Similar Products]
 NCBI Protein Information    coagulation factor VIII
 UniProt Protein Name    Coagulation factor VIII
 UniProt Synonym Protein Names   
Antihemophilic factor; AHF
 Protein Family    Factor VIII intron 22 protein
 UniProt Gene Name    F8 [Similar Products]
 UniProt Synonym Gene Names    F8C; AHF [Similar Products]
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 NCBI Summary for F8    This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
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 UniProt Comments for F8    F8: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Defects in F8 are the cause of hemophilia A (HEMA). A disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery. Of particular interest for the understanding of the function of F8 is the category of CRM (cross-reacting material) positive patients (approximately 5%) that have considerable amount of F8 in their plasma (at least 30% of normal), but the protein is non- functional; i.e. the F8 activity is much less than the plasma protein level. CRM-reduced is another category of patients in which the F8C antigen and activity are reduced to approximately the same level. Most mutations are CRM negative, and probably affect the folding and stability of the protein. Belongs to the multicopper oxidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: endoplasmic reticulum lumen; ER to Golgi transport vesicle; ER-Golgi intermediate compartment membrane; extracellular region; plasma membrane

Molecular Function: protein binding

Biological Process: blood coagulation; blood coagulation, intrinsic pathway; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; platelet degranulation

Disease: Hemophilia A
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 Research Articles on F8    1. von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with F8 plasmaPathways associated with F8 plasma
 Reference Product  PubMed Publications
 VWF plasma  >75 publications with F8 and VWF
 F10 plasma  >33 publications with F8 and F10
 PROC plasma  >23 publications with F8 and PROC
 MCFD2 plasma  >2 publications with F8 and MCFD2
 PROS1 plasma  >1 publications with F8 and PROS1
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 Common Pathway Of Fibrin Clot Formation antibodies  Common Pathway Of Fibrin Clot Formation Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Diseases associated with F8 plasmaOrgans/Tissues associated with F8 plasma
 Disease Name  Pubmed Publications
 Hemophilia A Antibodies  >691 publications with F8 and Hemophilia A
 Hemorrhage Antibodies  >165 publications with F8 and Hemorrhage
 Nervous System Diseases Antibodies  >132 publications with F8 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >119 publications with F8 and Cardiovascular Diseases
 Thrombosis Antibodies  >103 publications with F8 and Thrombosis
 Brain Diseases Antibodies  >62 publications with F8 and Brain Diseases
 Inflammation Antibodies  >37 publications with F8 and Inflammation
 Heart Diseases Antibodies  >34 publications with F8 and Heart Diseases
 Venous Thrombosis Antibodies  >32 publications with F8 and Venous Thrombosis
 Kidney Diseases Antibodies  >28 publications with F8 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >712 publications with F8 and Blood
 Brain Antibodies  >171 publications with F8 and Brain
 Vascular Antibodies  >112 publications with F8 and Vascular
 Muscle Antibodies  >58 publications with F8 and Muscle
 Kidney Antibodies  >56 publications with F8 and Kidney
 Liver Antibodies  >51 publications with F8 and Liver
 Heart Antibodies  >50 publications with F8 and Heart
 Lung Antibodies  >31 publications with F8 and Lung
 Skin Antibodies  >29 publications with F8 and Skin
 Nerve Antibodies  >28 publications with F8 and Nerve
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