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ARHGEF7 positive control

Scan QR to view Datasheet Catalog #    MBS542546 ARHGEF7 positive control
Unit / Price
5 Applications  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARHGEF7, Positive Control

 Also Known As   

ARHGEF7 Antibody Western Blot Positive Control

 Product Synonym Names    ARHG7; Beta pix; COOL1; Nbla10314; P50; p85; P85SPR; PAK interacting exchange factor beta; PAK3; SH3 domain containing proline rich protein antibody
 Product Gene Name   

ARHGEF7 positive control

[Similar Products]
 Matching Pairs    Antibody: ARHGEF7 (MBS540735)
Positive Control: ARHGEF7 (MBS542546)
 Matching Pairs    Antibody: ARHGEF7 (MBS541013)
Positive Control: ARHGEF7 (MBS542546)
 Matching Pairs    Antibody: ARHGEF7 (MBS541014)
Positive Control: ARHGEF7 (MBS542546)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605477
 3D Structure    ModBase 3D Structure for Q14155
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 Form/Format    Western Blot Positive Control
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 Immunogen    Purified Protein
 Molecular Function    Neurogenesis
 Structure    Interacts with PAK kinases through SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1.
 Subcellular Location    Cell junction; foacl adhesion; Cell projection ruffle; Cell cortex
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of ARHGEF7 positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ARHGEF7 positive control

   Western Blot Positive Control Rho-guanine nucleotide exchange factor 7 Antibody
Acts as RAC1 guanine nucleotide exchange factor and can induce membrane ruffling.
 Applications Tested/Suitable for ARHGEF7 positive control   

Western Blot (WB)

 Application Notes for ARHGEF7 positive control    Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for ARHGEF7. It may not necessarily be applicable to this product.
 NCBI GI #    50403776
 NCBI GeneID    8874
 NCBI Accession #    Q14155.2 [Other Products]
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 UniProt Primary Accession #    Q14155 [Other Products]
 UniProt Secondary Accession #    Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1; B1ALK6; B1ALK8 [Other Products]
 UniProt Related Accession #    Q14155 [Other Products]
 Molecular Weight    70,450 Da
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 NCBI Official Full Name    Rho guanine nucleotide exchange factor 7
 NCBI Official Synonym Full Names    Rho guanine nucleotide exchange factor 7
 NCBI Official Symbol    ARHGEF7 [Similar Products]
 NCBI Official Synonym Symbols   
P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314
[Similar Products]
 NCBI Protein Information    rho guanine nucleotide exchange factor 7
 UniProt Protein Name    Rho guanine nucleotide exchange factor 7
 UniProt Synonym Protein Names   
Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85
 Protein Family    Rho guanine nucleotide exchange factor
 UniProt Gene Name    ARHGEF7 [Similar Products]
 UniProt Synonym Gene Names    COOL1; KIAA0142; P85SPR; PAK3BP; PIXB [Similar Products]
 UniProt Entry Name    ARHG7_HUMAN
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 NCBI Summary for ARHGEF7    This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
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 UniProt Comments for ARHGEF7    ARHGEF7: a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described.

Protein type: GEFs, Rac/Rho; Motility/polarity/chemotaxis; GEFs

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cell cortex; cell soma; cytosol; focal adhesion; lamellipodium; neuron projection; plasma membrane; protein complex; ruffle

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein kinase binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: ephrin receptor signaling pathway; focal adhesion formation; Golgi organization and biogenesis; hemopoietic progenitor cell differentiation; lamellipodium biogenesis; negative regulation of epidermal growth factor receptor signaling pathway; nervous system development; positive regulation of apoptosis; positive regulation of growth hormone secretion; positive regulation of GTPase activity; positive regulation of protein binding; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction
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 Research Articles on ARHGEF7    1. Data show the role of Rho guanine nucleotide exchange factor 7 (beta-PIX) to the regulation of high mobility of lung adenocarcinoma cell line H1299 via regulation of focal adhesions dynamics, changes in actin cytoskeleton organization and cell polarity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ARHGEF7 positive controlPathways associated with ARHGEF7 positive control
 Reference Product  PubMed Publications
 CDC42 positive control  >39 publications with ARHGEF7 and CDC42
 RAC1 positive control  >36 publications with ARHGEF7 and RAC1
 SRC positive control  >14 publications with ARHGEF7 and SRC
 PAK1 positive control  >14 publications with ARHGEF7 and PAK1
 GIT1 positive control  >14 publications with ARHGEF7 and GIT1
 GIT2 positive control  >8 publications with ARHGEF7 and GIT2
 CBL positive control  >5 publications with ARHGEF7 and CBL
 PAK2 positive control  >4 publications with ARHGEF7 and PAK2
 Products by Pathway  Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EGFR Downregulation Pathway antibodies  EGFR Downregulation Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 Ephrin Signaling Pathway antibodies  Ephrin Signaling Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
Diseases associated with ARHGEF7 positive controlOrgans/Tissues associated with ARHGEF7 positive control
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with ARHGEF7 and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with ARHGEF7 and Disease Models, Animal
 Brain Diseases Antibodies  >2 publications with ARHGEF7 and Brain Diseases
 Kidney Diseases Antibodies  >2 publications with ARHGEF7 and Kidney Diseases
 Neurobehavioral Manifestations Antibodies  >2 publications with ARHGEF7 and Neurobehavioral Manifestations
 Fibrosis Antibodies  >1 publications with ARHGEF7 and Fibrosis
 Nervous System Malformations Antibodies  >1 publications with ARHGEF7 and Nervous System Malformations
 Vascular Diseases Antibodies  >1 publications with ARHGEF7 and Vascular Diseases
 Inflammation Antibodies  >1 publications with ARHGEF7 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with ARHGEF7 and Brain
 Blood Antibodies  >10 publications with ARHGEF7 and Blood
 Kidney Antibodies  >9 publications with ARHGEF7 and Kidney
 Lung Antibodies  >5 publications with ARHGEF7 and Lung
 Heart Antibodies  >4 publications with ARHGEF7 and Heart
 Bone Antibodies  >4 publications with ARHGEF7 and Bone
 Bone Marrow Antibodies  >3 publications with ARHGEF7 and Bone Marrow
 Vascular Antibodies  >3 publications with ARHGEF7 and Vascular
 Embryonic Tissue Antibodies  >2 publications with ARHGEF7 and Embryonic Tissue
 Muscle Antibodies  >2 publications with ARHGEF7 and Muscle
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