Q14155.2
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,450 Da
NCBI Official Full Name
Rho guanine nucleotide exchange factor 7
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor 7
NCBI Official Synonym Symbols
P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314 [Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 7
UniProt Protein Name
Rho guanine nucleotide exchange factor 7
UniProt Synonym Protein Names
Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85
UniProt Synonym Gene Names
UniProt Entry Name
ARHG7_HUMAN
NCBI Summary for ARHGEF7
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
UniProt Comments for ARHGEF7
ARHGEF7: a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described.
Protein type: GEFs, Rac/Rho; Motility/polarity/chemotaxis; GEFs
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: cell cortex; cell soma; cytosol; focal adhesion; lamellipodium; neuron projection; plasma membrane; protein complex; ruffle
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein kinase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: ephrin receptor signaling pathway; focal adhesion formation; Golgi organization and biogenesis; hemopoietic progenitor cell differentiation; lamellipodium biogenesis; negative regulation of epidermal growth factor receptor signaling pathway; nervous system development; positive regulation of apoptosis; positive regulation of growth hormone secretion; positive regulation of GTPase activity; positive regulation of protein binding; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction
Research Articles on ARHGEF7
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with ARHGEF7 positive control
Pathways associated with ARHGEF7 positive control
Diseases associated with ARHGEF7 positive control
Organs/Tissues associated with ARHGEF7 positive control
|