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BST2 positive control

Scan QR to view Datasheet Catalog #    MBS542577 BST2 positive control
Unit / Price
5 Applications  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BST2, Positive Control

 Also Known As   

BST2 Positive Control

 Product Synonym Names    Bone marrow stromal antigen 2; Bone marrow stromal cell antigen 2; BST 2; CD 317; CD317 antigen; HM1.24 antigen; NPC A 7; Tetherin antibody
 Product Gene Name   

BST2 positive control

[Similar Products]
 Matching Pairs    Antibody: BST2 (MBS540010)
Positive Control: BST2 (MBS542577)
 Matching Pairs    Antibody: BST2 (MBS540223)
Positive Control: BST2 (MBS542577)
 Matching Pairs    Antibody: BST2 (MBS540283)
Positive Control: BST2 (MBS542577)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600534
 3D Structure    ModBase 3D Structure for Q10589
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 Form/Format    Western Blot Positive Control
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 Immunogen    Purified Protein
 Expression    Liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal msucle and brain. Overexpressed in multiple myeloma cells. B-cells, T-cells, monocytes, NK cells and dendritic cells. Induced by type I interforns. Down regulated by viral antagonistic factors.
 Molecular Function    Antiviral defense; B-cell activation; Immunity; Innate immunity
 Structure    Parallel homodimer; disulfide linked. Cytoplasmic domain interacts with ARHGAP44 and MMP14.
 Subcellular Location    Gogli apparatus, trans-golgi network; Cell membrane, Single-pass type II membrane protein. Lipid anchor, GPI anchor; Late endosome; Membrane raft; Cytoplasm; Apical cell membrane
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of BST2 positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BST2 positive control

   Western Blot Positive Control Bonemarrow stromal antigen 2
IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells.
 Applications Tested/Suitable for BST2 positive control   

Western Blot (WB)

 Application Notes for BST2 positive control    Western Blot: 1:500-1:1,000
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NCBI/Uniprot data below describe general gene information for BST2. It may not necessarily be applicable to this product.
 NCBI GI #    62897809
 NCBI GeneID    684
 NCBI Accession #    BAD96844 [Other Products]
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 UniProt Primary Accession #    Q10589 [Other Products]
 UniProt Secondary Accession #    Q53G07; A8K4Y4 [Other Products]
 UniProt Related Accession #    Q10589 [Other Products]
 Molecular Weight    18,394 Da
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 NCBI Official Full Name    bone marrow stromal cell antigen 2 variant, partial
 NCBI Official Synonym Full Names    bone marrow stromal cell antigen 2
 NCBI Official Symbol    BST2 [Similar Products]
 NCBI Official Synonym Symbols   
CD317; TETHERIN
[Similar Products]
 NCBI Protein Information    bone marrow stromal antigen 2
 UniProt Protein Name    Bone marrow stromal antigen 2
 UniProt Synonym Protein Names   
HM1.24 antigen; Tetherin; CD_antigen: CD317
 Protein Family    Bone marrow stromal antigen
 UniProt Gene Name    BST2 [Similar Products]
 UniProt Synonym Gene Names    BST-2 [Similar Products]
 UniProt Entry Name    BST2_HUMAN
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 NCBI Summary for BST2    Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BST2    BST2: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason- Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma- associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Belongs to the tetherin family.

Protein type: Cell development/differentiation; Membrane protein, integral; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: apical plasma membrane; cell surface; cytoplasm; Golgi apparatus; integral to plasma membrane; late endosome; lipid raft; membrane; multivesicular body; plasma membrane

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; protein homodimerization activity; signal transducer activity

Biological Process: B cell activation; cell proliferation; cell-cell signaling; defense response to virus; humoral immune response; innate immune response; multicellular organismal development; negative regulation of cell growth; negative regulation of cell migration; negative regulation of plasmacytoid dendritic cell cytokine production; negative regulation of viral genome replication; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of actin cytoskeleton organization and biogenesis; response to virus
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 Research Articles on BST2    1. BST-2 restricts Hepatitis B virus production at intracellular multivesicular bodies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BST2 positive controlPathways associated with BST2 positive control
 Reference Product  PubMed Publications
 APOBEC3G positive control  >24 publications with BST2 and APOBEC3G
 TRIM5 positive control  >16 publications with BST2 and TRIM5
 IRF7 positive control  >1 publications with BST2 and IRF7
 ARHGAP44 positive control  >1 publications with BST2 and ARHGAP44
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
Diseases associated with BST2 positive controlOrgans/Tissues associated with BST2 positive control
 Disease Name  Pubmed Publications
 Multiple Myeloma Antibodies  >27 publications with BST2 and Multiple Myeloma
 Inflammation Antibodies  >16 publications with BST2 and Inflammation
 Skin Diseases Antibodies  >10 publications with BST2 and Skin Diseases
 Breast Neoplasms Antibodies  >7 publications with BST2 and Breast Neoplasms
 Liver Diseases Antibodies  >5 publications with BST2 and Liver Diseases
 Nervous System Diseases Antibodies  >5 publications with BST2 and Nervous System Diseases
 Lung Neoplasms Antibodies  >4 publications with BST2 and Lung Neoplasms
 Kidney Diseases Antibodies  >4 publications with BST2 and Kidney Diseases
 Liver Neoplasms Antibodies  >4 publications with BST2 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with BST2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >87 publications with BST2 and Blood
 Bone Antibodies  >80 publications with BST2 and Bone
 Bone Marrow Antibodies  >79 publications with BST2 and Bone Marrow
 Brain Antibodies  >8 publications with BST2 and Brain
 Kidney Antibodies  >8 publications with BST2 and Kidney
 Liver Antibodies  >7 publications with BST2 and Liver
 Spleen Antibodies  >6 publications with BST2 and Spleen
 Uterus Antibodies  >6 publications with BST2 and Uterus
 Lung Antibodies  >5 publications with BST2 and Lung
 Skin Antibodies  >4 publications with BST2 and Skin
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