NP_598196.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
24,438 Da
NCBI Official Full Name
NKG2-D type II integral membrane protein
NCBI Official Synonym Full Names
killer cell lectin like receptor K1
NCBI Official Synonym Symbols
NCBI Protein Information
NKG2-D type II integral membrane protein
UniProt Protein Name
NKG2-D type II integral membrane protein
UniProt Synonym Protein Names
Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NK lectin-like receptor; NKLLR; NKG2-D-activating NK receptor; NKR-P2; CD_antigen: CD314
UniProt Synonym Gene Names
UniProt Entry Name
NKG2D_RAT
NCBI Summary for NKG2D
functions as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells [RGD, Feb 2006]
UniProt Comments for NKG2D
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
Research Articles on NKG2D
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Products associated with NKG2D positive control
Diseases associated with NKG2D positive control
Organs/Tissues associated with NKG2D positive control
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