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SGLT2 positive control

Scan QR to view Datasheet Catalog #    MBS543251 SGLT2 positive control
Unit / Price
5 Applications  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SGLT2, Positive Control

★Popular Item★
 Also Known As   

SGLT2 Positive Control

 Product Synonym Names    Low affinity sodium glucose cotransporter; Na(+) glucose cotransporter 2; SGLT 2; SLC5A2; Sodium glucose cotransporter 2; Solute carrier family 5 (sodium glucose cotransporter) member 2 antibodySolute carrier family 5 member 2 antibody
 Product Gene Name   

SGLT2 positive control

[Similar Products]
 Matching Pairs    Antibody: SGLT2 (MBS544866)
Positive Control: SGLT2 (MBS543251)
 Matching Pairs    Antibody: SGLT2 (MBS544867)
Positive Control: SGLT2 (MBS543251)
 Matching Pairs    Antibody: SGLT2 (MBS544868)
Positive Control: SGLT2 (MBS543251)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    182381
 3D Structure    ModBase 3D Structure for P31639
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 Form/Format    Western Blot Positive Control in ready to use SDS-sample buffer
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 Immunogen    Purified Protein
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 Preparation and Storage    Store at -20C for long term storage
 Other Notes    Small volumes of SGLT2 positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SGLT2 positive control

   Western Blot Positive Control Sodium/glucose cotransporter 2
Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1.
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.
 Applications Tested/Suitable for SGLT2 positive control   

Western Blot (WB)

 Application Notes for SGLT2 positive control    Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for SGLT2. It may not necessarily be applicable to this product.
 NCBI GI #    4507033
 NCBI GeneID    6524
 NCBI Accession #    NP_003032 [Other Products]
 NCBI GenBank Nucleotide #    NM_003041.3 [Other Products]
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 UniProt Primary Accession #    P31639 [Other Products]
 UniProt Secondary Accession #    A2RRD2 [Other Products]
 UniProt Related Accession #    P31639 [Other Products]
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 NCBI Official Full Name    sodium/glucose cotransporter 2
 NCBI Official Synonym Full Names    solute carrier family 5 member 2
 NCBI Official Symbol    SLC5A2 [Similar Products]
 NCBI Official Synonym Symbols   
SGLT2
[Similar Products]
 NCBI Protein Information    sodium/glucose cotransporter 2
 UniProt Protein Name    Sodium/glucose cotransporter 2
 UniProt Synonym Protein Names   
Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
 UniProt Gene Name    SLC5A2 [Similar Products]
 UniProt Synonym Gene Names    SGLT2; Na(+)/glucose cotransporter 2 [Similar Products]
 UniProt Entry Name    SC5A2_HUMAN
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 NCBI Summary for SGLT2    This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
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 UniProt Comments for SGLT2    SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: brush border membrane; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: glucose:sodium symporter activity; low-affinity glucose:sodium symporter activity

Biological Process: carbohydrate metabolic process; sodium ion transport; transport

Disease: Renal Glucosuria
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 Research Articles on SGLT2    1. Data show that thiosugars bind to sodium-glucose co-transporters vSGLT and hSGLT2 stronger and dissociate more slowly than sugars.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SGLT2 positive controlDiseases associated with SGLT2 positive control
 Products by Pathway  Pathway Diagram
 Hexose Transport Pathway antibodies  Hexose Transport Pathway Diagram
 Inositol Transporters Pathway antibodies  Inositol Transporters Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Na+-dependent Glucose Transporters Pathway antibodies  Na+-dependent Glucose Transporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >194 publications with SGLT2 and Diabetes Mellitus, Type 2
 Kidney Diseases Antibodies  >60 publications with SGLT2 and Kidney Diseases
 Glycosuria, Renal Antibodies  >56 publications with SGLT2 and Glycosuria, Renal
 Weight Loss Antibodies  >40 publications with SGLT2 and Weight Loss
 Body Weight Changes Antibodies  >23 publications with SGLT2 and Body Weight Changes
 Cardiovascular Diseases Antibodies  >17 publications with SGLT2 and Cardiovascular Diseases
 Hypertension Antibodies  >12 publications with SGLT2 and Hypertension
 Death Antibodies  >8 publications with SGLT2 and Death
 Inflammation Antibodies  >7 publications with SGLT2 and Inflammation
 Glucose Intolerance Antibodies  >6 publications with SGLT2 and Glucose Intolerance
Organs/Tissues associated with SGLT2 positive control
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >140 publications with SGLT2 and Kidney
 Pancreas Antibodies  >11 publications with SGLT2 and Pancreas
 Intestine Antibodies  >6 publications with SGLT2 and Intestine
 Brain Antibodies  >2 publications with SGLT2 and Brain
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