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POMC protein :: ACTH Protein

Scan QR to view Datasheet Catalog #    MBS844003
Testing Data
Unit / Price
2 mg  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTH (POMC), Protein

 Also Known As   

ACTH

 Product Synonym Names    Corticotropin-lipotropin; Pro-opiomelanocortin; POMC; ACTH; LPH; MSH; NPP; POC; CLIP; Tetracosactide; Adrenocorticotropin receptor; Melanocortin receptor 2; Corticotropin-lipotropin; Pro-opiomelanocortin; POMC; ACTH; LPH; MSH; NPP; POC; CLIP; Tetracosactide.
 Product Gene Name   

POMC protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176830
 3D Structure    ModBase 3D Structure for P01189
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 Host    Synthetic
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 Purity/Purification    >=98%
 Form/Format    Sterile filtered and lyophilized with no additives
Appearance: Lyophilized
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 Solubility/Reconstitution Instructions    Centrifuge the vial prior to opening. Reconstitute in sterile dW to a concentration >= 100 ug/ml. This solution can then be diluted into other aqueous buffers and stored at 4 degree C for 2-7 days and at -20 degree C for future use.
 Handling    Centrifuge the vial prior to opening.
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 Preparation and Storage    At -20 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of POMC protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for POMC protein

   Background: Adrenocorticotropic hormone, as its name implies, stimulates the adrenal cortex. More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex. Stimulates secretion of adrenal corticosteroids and induces growth of adrenal cortex. ACTH also called Tetracosactide directly activates G-proteins. A stimulator of adenylate cyclase and cAMP formation. Its molecular weight is 4.541 kDa.
 Product Categories/Family for POMC protein    Proteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & Enzymes
 Applications Tested/Suitable for POMC protein   

SDS-PAGE; HPLC

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 Testing Data of POMC protein    POMC protein Testing Data image
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NCBI/Uniprot data below describe general gene information for POMC. It may not necessarily be applicable to this product.
 NCBI GI #    4505949
 NCBI GeneID    5443
 NCBI Accession #    NP_000930.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000939.2 [Other Products]
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 UniProt Primary Accession #    P01189 [Other Products]
 UniProt Secondary Accession #    P78442; Q53T23; Q9UD39; Q9UD40 [Other Products]
 UniProt Related Accession #    P01189 [Other Products]
 Molecular Weight    2.9335 kDa
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 NCBI Official Full Name    pro-opiomelanocortin preproprotein
 NCBI Official Synonym Full Names    proopiomelanocortin
 NCBI Official Symbol    POMC [Similar Products]
 NCBI Official Synonym Symbols   
LPH; MSH; NPP; POC; ACTH; CLIP
[Similar Products]
 NCBI Protein Information    pro-opiomelanocortin
 UniProt Protein Name    Pro-opiomelanocortin
 UniProt Synonym Protein Names   
Corticotropin-lipotropin
 Protein Family    Corticotropin
 UniProt Gene Name    POMC [Similar Products]
 UniProt Synonym Gene Names    POMC; ACTH; CLIP [Similar Products]
 UniProt Entry Name    COLI_HUMAN
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 NCBI Summary for POMC    This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Nov 2014]
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 UniProt Comments for POMC    POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: peroxisomal matrix; extracellular space; cytoplasm; extracellular region; peroxisome; secretory granule

Molecular Function: type 3 melanocortin receptor binding; G-protein-coupled receptor binding; hormone activity; type 4 melanocortin receptor binding; receptor binding

Biological Process: generation of precursor metabolites and energy; cellular protein metabolic process; cell-cell signaling; neuropeptide signaling pathway; regulation of blood pressure; peptide hormone processing; regulation of appetite; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; signal transduction; glucose homeostasis; cellular pigmentation

Disease: Obesity; Proopiomelanocortin Deficiency
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 Research Articles on POMC    1. Term infants born with meconium-stained amniotic fluid (MSAF) and who experienced respiratory distress had significantly lower levels of ACTH and cortisol at birth compared with well term infants born with MSAF or clear amniotic fluid.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with POMC proteinDiseases associated with POMC protein
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Metabolism Pathway antibodies  Diseases Of Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4210 publications with POMC and Immune System Diseases
 Cushing Syndrome Antibodies  >2915 publications with POMC and Cushing Syndrome
 Mental Disorders Antibodies  >2687 publications with POMC and Mental Disorders
 Obesity Antibodies  >1782 publications with POMC and Obesity
 Infection Antibodies  >1026 publications with POMC and Infection
 Kidney Diseases Antibodies  >1012 publications with POMC and Kidney Diseases
 Gastrointestinal Diseases Antibodies  >947 publications with POMC and Gastrointestinal Diseases
 Diabetes Mellitus Antibodies  >861 publications with POMC and Diabetes Mellitus
 Necrosis Antibodies  >676 publications with POMC and Necrosis
 Hemorrhage Antibodies  >674 publications with POMC and Hemorrhage
Organs/Tissues associated with POMC protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18604 publications with POMC and Brain
 Pituitary Gland Antibodies  >9037 publications with POMC and Pituitary Gland
 Lung Antibodies  >995 publications with POMC and Lung
 Eye Antibodies  >619 publications with POMC and Eye
 Testis Antibodies  >556 publications with POMC and Testis
 Intestine Antibodies  >436 publications with POMC and Intestine
 Embryonic Tissue Antibodies  >393 publications with POMC and Embryonic Tissue
 Placenta Antibodies  >367 publications with POMC and Placenta
 Uterus Antibodies  >240 publications with POMC and Uterus
 Uncharacterized Tissue Antibodies  >2 publications with POMC and Uncharacterized Tissue
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