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ACTC1 protein :: Actin, Cardiac Protein

Scan QR to view Datasheet Catalog #    MBS635219 ACTC1 protein
Unit / Price
0.1 mg  /  $680 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Actin, Cardiac (ACTC1), Protein

 Also Known As   

Actin, Cardiac

 Product Gene Name   

ACTC1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000015.9 (35080297..35087927, complement). Location: 15q14
 OMIM    102540
 3D Structure    ModBase 3D Structure for P68032
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 Host    Bovine heart
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 Purity/Purification    >98% (SDS-PAGE)
 Form/Format    Supplied as a lyophilized powder from 10mM Tris-acetate buffer, pH 8.0, 0.2mM CaCl2, 0.2mM ATP, 1mM DTT, 0.5% SDS.
 Concentration    ~1mg/ml (after reconstitution) (lot specific)
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 Isoelectric Point    pI 5.4
 Reconstitution    Reconstitute to <1mg/ml with sterile ddH2O.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Reconstitute to nominal volume by adding sterile H2O. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of ACTC1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for ACTC1 protein    Molecular Biology; MB-Actin Related Proteins
 Applications Tested/Suitable for ACTC1 protein   

Gel Shift Assay (GS/EMSA)

 Application Notes for ACTC1 protein    Suitable for use as a Protein standard in 1D and 2D SDS gel electrophoresis, in Immunoassays and for Immunization.
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NCBI/Uniprot data below describe general gene information for ACTC1. It may not necessarily be applicable to this product.
 NCBI GI #    4885049
 NCBI GeneID    70
 NCBI Accession #    NP_005150.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005159.4 [Other Products]
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 UniProt Primary Accession #    P68032 [Other Products]
 UniProt Secondary Accession #    P04270 [Other Products]
 UniProt Related Accession #    P68032 [Other Products]
 Molecular Weight    43kD [Similar Products]
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 NCBI Official Full Name    actin, alpha cardiac muscle 1 proprotein
 NCBI Official Synonym Full Names    actin, alpha, cardiac muscle 1
 NCBI Official Symbol    ACTC1 [Similar Products]
 NCBI Official Synonym Symbols   
ACTC; ASD5; CMD1R; CMH11; LVNC4
[Similar Products]
 NCBI Protein Information    actin, alpha cardiac muscle 1
 UniProt Protein Name    Actin, alpha cardiac muscle 1
 UniProt Synonym Protein Names   
Alpha-cardiac actin
 Protein Family    Actin
 UniProt Gene Name    ACTC1 [Similar Products]
 UniProt Synonym Gene Names    ACTC [Similar Products]
 UniProt Entry Name    ACTC_HUMAN
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 NCBI Summary for ACTC1    Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACTC1    ACTC1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family.

Protein type: Contractile; Cytoskeletal; Motility/polarity/chemotaxis; Cell development/differentiation; Myosin-binding

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: I band; extracellular space; sarcomere; focal adhesion; membrane; cytoplasm; actin filament; cytosol

Molecular Function: myosin binding; ATPase activity; ATP binding

Biological Process: response to drug; apoptosis; metabolic process; muscle thin filament assembly; actin filament-based movement; actomyosin structure organization and biogenesis; cardiac myofibril assembly; muscle filament sliding; response to ethanol; heart contraction; cardiac muscle morphogensis; actin-myosin filament sliding; negative regulation of apoptosis; cardiac muscle contraction

Disease: Atrial Septal Defect 5; Cardiomyopathy, Familial Hypertrophic, 11; Cardiomyopathy, Dilated, 1r
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 Research Articles on ACTC1    1. The authors demonstrate that clathrin promotes clustering of the vaccinia virus actin tail nucleator A36 and host N-WASP, which activates actin nucleation through the Arp2/3 complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACTC1 proteinPathways associated with ACTC1 protein
 Reference Product  PubMed Publications
 MYH7 protein  >9 publications with ACTC1 and MYH7
 MYH6 protein  >4 publications with ACTC1 and MYH6
 ACTA1 protein  >1 publications with ACTC1 and ACTA1
 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Diseases associated with ACTC1 proteinOrgans/Tissues associated with ACTC1 protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >19 publications with ACTC1 and Cardiovascular Diseases
 Cardiomyopathy, Dilated Antibodies  >7 publications with ACTC1 and Cardiomyopathy, Dilated
 Cardiomyopathy, Familial Hypertrophic, 1 Antibodies  >3 publications with ACTC1 and Cardiomyopathy, Familial Hypertrophic, 1
 Neoplasms Antibodies  >2 publications with ACTC1 and Neoplasms
 Hypertrophy Antibodies  >2 publications with ACTC1 and Hypertrophy
 Cardiomyopathy, Familial Hypertrophic, 11 Antibodies  >2 publications with ACTC1 and Cardiomyopathy, Familial Hypertrophic, 11
 Disease Models, Animal Antibodies  >2 publications with ACTC1 and Disease Models, Animal
 Lung Diseases Antibodies  >1 publications with ACTC1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >1 publications with ACTC1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with ACTC1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >23 publications with ACTC1 and Muscle
 Heart Antibodies  >17 publications with ACTC1 and Heart
 Vascular Antibodies  >3 publications with ACTC1 and Vascular
 Lung Antibodies  >2 publications with ACTC1 and Lung
 Embryonic Tissue Antibodies  >2 publications with ACTC1 and Embryonic Tissue
 Bone Antibodies  >1 publications with ACTC1 and Bone
 Prostate Antibodies  >1 publications with ACTC1 and Prostate
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