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GPT protein :: Alanine Aminotransferase Protein

Scan QR to view Datasheet Catalog #    MBS173089 GPT protein
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 Product Name   

Alanine Aminotransferase (GPT), Protein

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 Also Known As   

Alanine Aminotransferase (ALT, GPT), Human Liver

 Product Synonym Names    Glutamate Pyruvate Transaminase; Alanine Transaminase; serum glutamic-pyruvic transaminase; SGPT; GPT; ALT; ALAT; Alanine Transaminase (ALT, GPT), Human Liver - Lyophilized
 Product Gene Name   

GPT protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138210
 3D Structure    ModBase 3D Structure for Q8TD30
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 Specificity    Liver damage or disease
 Purity/Purification    Purified
 Form/Format    Lyophilized
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 Source    Human Liver
 EC Number
 UNSPSC Code    51131907
 Unit Definition    One unit will catalyze the transamination of one micromole of L-alanine to alpha-ketoglutarate, forming L-glutamate and pyruvate per minute at 37 degree C and pH 7.8. Measured at 340 nm as one equimolar amount of NAD produced by a coupled reaction.
 Specific Activity    >= 10 U/mg protein
 Recertification    3 years
 Protein    >= 0.5 mg protein/mg (Coomassie)
 Contaminants    ALP: <=0.1%, CK: <=0.1%, gGT: <=0.1%, AST/SGOT: <=3%, LDH: <=1%
 CAS Number    9000-86-6
 Additional Info    Homodimer
 Activity    >= 5 U/mg (Dimension Clinical Chemistry System)
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of GPT protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GPT protein

   MyBioSource is the leading producer of Alanine Aminotransferase (ALT, GPT), Human Liver for research and diagnostic use. We are able to custom fill alanine aminotransferase.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human GPT/ALT is an enzyme that catalyzes the reversible transfer of an amino group from alanine to a-ketoglutarate. Human alanine aminotransferase (ALT) is found in serum and in various bodily tissues but is most commonly associated with the liver. Also called serum glutamate pyruvate transaminase (SGPT) or alanine aminotransferase.

Elevated levels of Alanine transaminase (ALT) often suggest the existence of other medical problems such as alcoholism, viral hepatitis, congestive heart failure, liver damage, biliary duct problems, infectious mononucleosis, or myopathy.
 Product Categories/Family for GPT protein    Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Alanine Aminotransferase (alt; Gpt)
NCBI/Uniprot data below describe general gene information for GPT. It may not necessarily be applicable to this product.
 NCBI GI #    1763096
 NCBI GeneID    2875
 NCBI Accession #    AAC51155.1 [Other Products]
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 UniProt Primary Accession #    Q8TD30 [Other Products]
 UniProt Secondary Accession #    Q8N9E2 [Other Products]
 UniProt Related Accession #    P24298 [Other Products]
 Molecular Weight    57,903.6 based on the sequence [Similar Products]
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 NCBI Official Full Name    glutamate pyruvate transaminase
 NCBI Official Synonym Full Names    glutamic-pyruvate transaminase (alanine aminotransferase)
 NCBI Official Symbol    GPT [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    alanine aminotransferase 1; GPT 1; glutamic-alanine transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamate pyruvate transaminase 1
 UniProt Protein Name    Alanine aminotransferase 2
 UniProt Synonym Protein Names   
Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2
 Protein Family    Alanine aminotransferase
 UniProt Gene Name    GPT2 [Similar Products]
 UniProt Synonym Gene Names    AAT2; ALT2; ALT2; GPT 2 [Similar Products]
 UniProt Entry Name    ALAT2_HUMAN
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 NCBI Summary for GPT    This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
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 UniProt Comments for GPT    GPT2: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: mitochondrial matrix

Molecular Function: alanine transaminase activity; pyridoxal phosphate binding

Biological Process: amino acid biosynthetic process; L-alanine metabolic process; 2-oxoglutarate metabolic process; L-alanine catabolic process

Disease: Mental Retardation, Autosomal Recessive 49
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 Research Articles on GPT    1. Among patients with chronic HCV infection, daily consumption of filtered coffee may have a beneficial effect on the stabilization of ALT levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GPT proteinDiseases associated with GPT protein
 Reference Product  PubMed Publications
 LDHB protein  >1 publications with GPT and LDHB
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >3 publications with GPT and Fatty Liver
 Fetal Growth Retardation Antibodies  >1 publications with GPT and Fetal Growth Retardation
 Liver Diseases Antibodies  >1 publications with GPT and Liver Diseases
Organs/Tissues associated with GPT protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with GPT and Blood
 Liver Antibodies  >5 publications with GPT and Liver
 Adipose Tissue Antibodies  >2 publications with GPT and Adipose Tissue
 Muscle Antibodies  >2 publications with GPT and Muscle
 Heart Antibodies  >1 publications with GPT and Heart
 Placenta Antibodies  >1 publications with GPT and Placenta
 Lung Antibodies  >1 publications with GPT and Lung
 Thyroid Antibodies  >1 publications with GPT and Thyroid
 Intestine Antibodies  >1 publications with GPT and Intestine
 Kidney Antibodies  >1 publications with GPT and Kidney
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