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SERPINA1 protein :: Alpha 1 Antitrypsin Protein

Scan QR to view Datasheet Catalog #    MBS844051
Testing Data
Unit / Price
1 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha 1 Antitrypsin (SERPINA1), Protein

★Popular Item★
 Also Known As   

Alpha 1 Antitrypsin, Human Plasma

 Product Synonym Names    Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1; AAT; PI
 Product Gene Name   

SERPINA1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107400
 3D Structure    ModBase 3D Structure for P01009
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 Purity/Purification    >=95% by SDS-PAGE
 Form/Format    Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.
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 Source    Human Plasma. Shown to be non-ractive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV1&2 by FDA approved tests.
 Extinction Coefficient    0.433
 Activity    Shows 75-100% inhibition when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.
    
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 Preparation and Storage    Store at -20 degree C or lower. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SERPINA1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SERPINA1 protein

   Background: Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.
 Product Categories/Family for SERPINA1 protein    Proteins and Enzymes; Native Proteins (NEW CATEGORY)Proteins and Enzymes; Proteases; Trypsin (NEW CATEGORY)Proteins and Enzymes; Proteins and Enzymes (A-Z)Apoptosis & Related Products; Non-Caspase Proteases; Trypsin
 Applications Tested/Suitable for SERPINA1 protein   

SDS-PAGE

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 Testing Data of SERPINA1 protein    SERPINA1 protein Testing Data image
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NCBI/Uniprot data below describe general gene information for SERPINA1. It may not necessarily be applicable to this product.
 NCBI GI #    50363217
 NCBI GeneID    5265
 NCBI Accession #    NP_000286.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000295.4 [Other Products]
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 UniProt Primary Accession #    P01009 [Other Products]
 UniProt Secondary Accession #    Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8 [Other Products]
 UniProt Related Accession #    P01009 [Other Products]
 Molecular Weight    52 kDa [Similar Products]
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 NCBI Official Full Name    alpha-1-antitrypsin
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
 NCBI Official Symbol    SERPINA1 [Similar Products]
 NCBI Official Synonym Symbols   
PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT
[Similar Products]
 NCBI Protein Information    alpha-1-antitrypsin
 UniProt Protein Name    Alpha-1-antitrypsin
 UniProt Synonym Protein Names   
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
 Protein Family    Alpha-1-antitrypsin
 UniProt Gene Name    SERPINA1 [Similar Products]
 UniProt Synonym Gene Names    AAT; PI; SPAAT [Similar Products]
 UniProt Entry Name    A1AT_HUMAN
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 NCBI Summary for SERPINA1    The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPINA1    SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding

Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; response to methanol; acute-phase response; response to hypoxia; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus

Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive
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 Research Articles on SERPINA1    1. Alpha-1 proteinase inhibitor M358R inhibits exogenous thrombin and is a membrane protein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SERPINA1 proteinPathways associated with SERPINA1 protein
 Reference Product  PubMed Publications
 ALB protein  >3 publications with SERPINA1 and ALB
 TIMP1 protein  >2 publications with SERPINA1 and TIMP1
 FN1 protein  >1 publications with SERPINA1 and FN1
 A2M protein  >1 publications with SERPINA1 and A2M
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with SERPINA1 proteinOrgans/Tissues associated with SERPINA1 protein
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >141 publications with SERPINA1 and Lung Diseases
 alpha 1-Antitrypsin Deficiency Antibodies  >137 publications with SERPINA1 and alpha 1-Antitrypsin Deficiency
 Liver Diseases Antibodies  >126 publications with SERPINA1 and Liver Diseases
 Pulmonary Disease, Chronic Obstructive Antibodies  >56 publications with SERPINA1 and Pulmonary Disease, Chronic Obstructive
 Inflammation Antibodies  >40 publications with SERPINA1 and Inflammation
 Pulmonary Emphysema Antibodies  >39 publications with SERPINA1 and Pulmonary Emphysema
 Cardiovascular Diseases Antibodies  >33 publications with SERPINA1 and Cardiovascular Diseases
 Liver Cirrhosis Antibodies  >31 publications with SERPINA1 and Liver Cirrhosis
 Carcinoma, Hepatocellular Antibodies  >21 publications with SERPINA1 and Carcinoma, Hepatocellular
 Fibrosis Antibodies  >20 publications with SERPINA1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >114 publications with SERPINA1 and Liver
 Blood Antibodies  >113 publications with SERPINA1 and Blood
 Lung Antibodies  >76 publications with SERPINA1 and Lung
 Skin Antibodies  >14 publications with SERPINA1 and Skin
 Vascular Antibodies  >13 publications with SERPINA1 and Vascular
 Pancreas Antibodies  >12 publications with SERPINA1 and Pancreas
 Kidney Antibodies  >11 publications with SERPINA1 and Kidney
 Heart Antibodies  >11 publications with SERPINA1 and Heart
 Bone Antibodies  >9 publications with SERPINA1 and Bone
 Muscle Antibodies  >8 publications with SERPINA1 and Muscle
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