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AHSG protein :: Alpha-2-HS-Glycoprotein, Human Plasma Protein

Scan QR to view Datasheet Catalog #    MBS135677
Testing Data
Unit / Price
1 mg  /  $365 +1 FREE 8GB USB
5 mg  /  $665 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-2-HS-Glycoprotein, Human Plasma (AHSG), Protein

★Popular Item★
 Also Known As   

Alpha-2-HS-Glycoprotein, Human Plasma

 Product Gene Name   

AHSG protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (186330850..186339107). Location: 3q27
 OMIM    138680
 3D Structure    ModBase 3D Structure for P02765
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 Host    Human plasma
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 Purity/Purification    >95% by SDS-PAGE analysis
 Form/Format    Lyophilized powder
 Concentration    Lyophilized
Volume: 0.296 ml before lyophilization (lot specific)
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 Aliquot    5 x 1.0 mg
 Buffer    0.02M Tris-HCl; 0.2M NaCl; pH 8.0
 Extinction Coefficient    0.54
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 3 years from delivery
 Other Notes    Small volumes of AHSG protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AHSG protein

   Found in human serum at 60 mg per 100 ml. This protein is a negative acute-phase reactant. Clinically, concentrations are reduced in cancer patients. AHSG levels are positively correlated with gestational diabetes and negatively correlated with neonatal skeletal development. Studies show AHSG to be present at high concentrations in the peritoneal fluids of patients with endometriosis. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests, > 95 percent pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unsused portion.
 Product Categories/Family for AHSG protein    Plasma Proteins; Human Plasma Proteins
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 Testing Data of AHSG protein    AHSG protein Testing Data image
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NCBI/Uniprot data below describe general gene information for AHSG. It may not necessarily be applicable to this product.
 NCBI GI #    156523970
 NCBI GeneID    197
 NCBI Accession #    NP_001613.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001622.2 [Other Products]
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 UniProt Primary Accession #    P02765 [Other Products]
 UniProt Secondary Accession #    O14961; O14962; Q9P152; A8K9N6; B2R7G1 [Other Products]
 UniProt Related Accession #    P02765; AAB29984 [Other Products]
 Molecular Weight    49,000
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 NCBI Official Full Name    alpha-2-HS-glycoprotein preproprotein
 NCBI Official Synonym Full Names    alpha-2-HS-glycoprotein
 NCBI Official Symbol    AHSG [Similar Products]
 NCBI Official Synonym Symbols   
AHS; A2HS; HSGA; FETUA
[Similar Products]
 NCBI Protein Information    alpha-2-HS-glycoprotein; fetuin-A; alpha-2-Z-globulin; ba-alpha-2-glycoprotein
 UniProt Protein Name    Alpha-2-HS-glycoprotein
 UniProt Synonym Protein Names   
Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-A
 Protein Family    Alpha-2-HS-glycoprotein
 UniProt Gene Name    AHSG [Similar Products]
 UniProt Synonym Gene Names    FETUA [Similar Products]
 UniProt Entry Name    FETUA_HUMAN
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 NCBI Summary for AHSG    Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AHSG    FETUA: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space; extracellular region

Molecular Function: kinase inhibitor activity; cysteine protease inhibitor activity

Biological Process: negative regulation of bone mineralization; pinocytosis; ossification; positive regulation of phagocytosis; regulation of inflammatory response; acute-phase response; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; regulation of bone mineralization; skeletal development
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 Research Articles on AHSG    1. Serum fetuin A levels were higher in prevalent hepatic steatosis patients with hepatic steatosis, and positively correlated with chemerin levels
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AHSG proteinPathways associated with AHSG protein
 Reference Product  PubMed Publications
 INSR protein  >2 publications with AHSG and INSR
 DCN protein  >2 publications with AHSG and DCN
 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
Diseases associated with AHSG proteinOrgans/Tissues associated with AHSG protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >129 publications with AHSG and Cardiovascular Diseases
 Kidney Diseases Antibodies  >103 publications with AHSG and Kidney Diseases
 Calcinosis Antibodies  >91 publications with AHSG and Calcinosis
 Inflammation Antibodies  >76 publications with AHSG and Inflammation
 Neoplasms Antibodies  >54 publications with AHSG and Neoplasms
 Heart Diseases Antibodies  >48 publications with AHSG and Heart Diseases
 Liver Diseases Antibodies  >35 publications with AHSG and Liver Diseases
 Brain Diseases Antibodies  >19 publications with AHSG and Brain Diseases
 Liver Neoplasms Antibodies  >17 publications with AHSG and Liver Neoplasms
 Hypertension Antibodies  >17 publications with AHSG and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >466 publications with AHSG and Blood
 Liver Antibodies  >79 publications with AHSG and Liver
 Heart Antibodies  >35 publications with AHSG and Heart
 Muscle Antibodies  >31 publications with AHSG and Muscle
 Brain Antibodies  >18 publications with AHSG and Brain
 Lung Antibodies  >10 publications with AHSG and Lung
 Embryonic Tissue Antibodies  >4 publications with AHSG and Embryonic Tissue
 Spleen Antibodies  >3 publications with AHSG and Spleen
 Thymus Antibodies  >2 publications with AHSG and Thymus
 Testis Antibodies  >2 publications with AHSG and Testis
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