Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Protein rightarrow A2M  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Serum albumin Antibody
 • 5'-AMP-activated protein kinase subunit beta-2 (Prkab2) Recombinant Protein
 • Retinol Binding Protein-4 (RBP4) Recombinant Protein
 • NeuN (RBFOX3) Antibody
 • growth hormone (GH) ELISA Kit
 • NUP62 cDNA Clone
 • nitric oxide synthase, NOS ELISA Kit
 • Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) ELISA Kit
 • CD20 (MS4A1) Antibody
 • Streptococcus pneumoniae Common C-polysaccharide Antibody
 • Kidney Injury Molecule 1 (KIM1) ELISA Kit
 • FBXO25 Antibody
 • GSTM1 Antibody
 • Alanine Transaminase (ALT) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

A2M protein :: Alpha-2-Macroglobulin Protein

Scan QR to view Datasheet Catalog #    MBS173011 A2M protein
Unit / Price
  DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha-2-Macroglobulin (A2M), Protein

 Also Known As   

Alpha-2 Macroglobulin (A2M), Rat Serum

 Product Synonym Names    Alpha-2 Macroglobulin (A2M), Rat Serum - >=90% (SDS-PAGE)
 Product Gene Name   

A2M protein

[Similar Products]
 Product Synonym Gene Name    A2MAC1; A2m1; A2maa; Mam [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    103950
Section Bar
Section Bar
 Purity/Purification    >= 90% (SDS-PAGE)
 Form/Format    Liquid
Section Bar
 Source    Rat Serum
 Recertification    2 years
 Protein    > 0.5 mg/mL (A280)
Section Bar
 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of A2M protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for A2M protein

   MyBioSource sells rat serum Alpha-2-Macroglobulin (A2M) for research and diagnostic manufacturing purposes.

Custom preparations, technical support, bulk quantities and aliquoting available.

Alpha-2-Macroglobulin is a large plasma protein found in the blood that is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis.

When high resolution images of rat acute-phase alpha 2-macroglobulin were performed, studies showed that the comparison of the amino acid compositions of the protein from rat and human serums indicated a high degree of homology between the two molecules. It was reported that the conformation of rat acute-phase alpha 2-macroglobulin, both at the molecular and secondary structural levels.
 Product Categories/Family for A2M protein    Proteins; Antigens; Standards/controls; Native Proteins; Alpha-2 Macroglobulin (a2m)
NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product.
 NCBI GI #    119608996
 NCBI GeneID    2
 NCBI Accession #    EAW88590.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q13677; Q59F47; Q5QTS0; Q68DN2; Q6PIY3; Q6PN97 [Other Products]
 UniProt Related Accession #    P01023 [Other Products]
 Molecular Weight    ~160,000
Table BarTOPTable Bar
 NCBI Official Full Name    alpha-2-macroglobulin
 NCBI Official Synonym Full Names    alpha-2-macroglobulin
 NCBI Official Symbol    A2M [Similar Products]
 NCBI Official Synonym Symbols   
A2MD; CPAMD5; FWP007; S863-7
[Similar Products]
 NCBI Protein Information    alpha-2-macroglobulin; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
 UniProt Protein Name    Alpha-2-macroglobulin
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
 Protein Family    Alpha-2-macroglobulin
 UniProt Gene Name    A2M [Similar Products]
 UniProt Synonym Gene Names    CPAMD5; Alpha-2-M [Similar Products]
 UniProt Entry Name    A2MG_HUMAN
Section Bar
 NCBI Summary for A2M    Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for A2M    A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: extracellular region; cytosol

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding

Biological Process: negative regulation of complement activation, lectin pathway; extracellular matrix disassembly; platelet activation; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway

Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency
Table BarTOPTable Bar
 Research Articles on A2M    1. phosphorylating the T-loop Akt residue Thr(308) by PDK1 requires Raptor of the mTORC1 complex as a platform or scaffold protein.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with A2M proteinPathways associated with A2M protein
 Reference Product  PubMed Publications
 APP protein  >17 publications with A2M and APP
 LRP1 protein  >12 publications with A2M and LRP1
 ALB protein  >6 publications with A2M and ALB
 APOA1 protein  >4 publications with A2M and APOA1
 PLG protein  >2 publications with A2M and PLG
 TGFB1 protein  >2 publications with A2M and TGFB1
 SERPINA1 protein  >1 publications with A2M and SERPINA1
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
Diseases associated with A2M proteinOrgans/Tissues associated with A2M protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >95 publications with A2M and Nervous System Diseases
 Mental Disorders Antibodies  >83 publications with A2M and Mental Disorders
 Alzheimer Disease Antibodies  >81 publications with A2M and Alzheimer Disease
 Inflammation Antibodies  >32 publications with A2M and Inflammation
 Necrosis Antibodies  >14 publications with A2M and Necrosis
 Liver Diseases Antibodies  >14 publications with A2M and Liver Diseases
 Lung Diseases Antibodies  >13 publications with A2M and Lung Diseases
 Disease Models, Animal Antibodies  >11 publications with A2M and Disease Models, Animal
 Fibrosis Antibodies  >11 publications with A2M and Fibrosis
 Carcinoma Antibodies  >8 publications with A2M and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >126 publications with A2M and Blood
 Liver Antibodies  >38 publications with A2M and Liver
 Brain Antibodies  >31 publications with A2M and Brain
 Vascular Antibodies  >15 publications with A2M and Vascular
 Lung Antibodies  >13 publications with A2M and Lung
 Heart Antibodies  >9 publications with A2M and Heart
 Prostate Antibodies  >9 publications with A2M and Prostate
 Uterus Antibodies  >6 publications with A2M and Uterus
 Ovary Antibodies  >6 publications with A2M and Ovary
 Embryonic Tissue Antibodies  >6 publications with A2M and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions