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SERPINC1 protein :: Antithrombin Protein

Scan QR to view Datasheet Catalog #    MBS634643 SERPINC1 protein
Unit / Price
1 mL  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Antithrombin (SERPINC1), Protein

 Also Known As   

Antithrombin, Human

 Product Gene Name   

SERPINC1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (173872938..173886516, complement). Location: 1q25.1
 OMIM    107300
 3D Structure    ModBase 3D Structure for P01008
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 Host    Antithrombin, from human plasma
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 Purity/Purification    Highly Purified
~95% (SDS-PAGE)
 Form/Format    Supplied as a liquid in 0.1M Tris-HCl, 0.15M sodium chloride, 0.02% sodium azide, pH 7.4.
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 Preparation and Storage    May be stored at 4 degree C. For long-term storage, aliquot and store at 4 degree C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of SERPINC1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for SERPINC1 protein    Molecular Biology; MB-Coagulation Factors
NCBI/Uniprot data below describe general gene information for SERPINC1. It may not necessarily be applicable to this product.
 NCBI GI #    28907
 NCBI GeneID    462
 NCBI Accession #    CAA48690.1 [Other Products]
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 UniProt Primary Accession #    P01008 [Other Products]
 UniProt Secondary Accession #    P78439; P78447; Q13815; Q5TC78; Q7KZ43; Q7KZ97; Q9UC78; B2R6P0 [Other Products]
 UniProt Related Accession #    P01008 [Other Products]
 Molecular Weight    ~58.2kD [Similar Products]
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 NCBI Official Full Name    antithrombin
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade C (antithrombin), member 1
 NCBI Official Symbol    SERPINC1 [Similar Products]
 NCBI Official Synonym Symbols   
AT3; AT3D; ATIII; THPH7
[Similar Products]
 NCBI Protein Information    antithrombin-III; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
 UniProt Protein Name    Antithrombin-III
 UniProt Synonym Protein Names   
Serpin C1
 Protein Family    Antithrombin
 UniProt Gene Name    SERPINC1 [Similar Products]
 UniProt Synonym Gene Names    AT3; ATIII [Similar Products]
 UniProt Entry Name    ANT3_HUMAN
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 NCBI Summary for SERPINC1    The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
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 UniProt Comments for SERPINC1    SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted; Inhibitor

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; protease binding

Biological Process: negative regulation of inflammatory response; blood coagulation; response to nutrient

Disease: Antithrombin Iii Deficiency
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 Research Articles on SERPINC1    1. analysis of compound heterozygosty of SERPINC1 in antithrombin deficiency [case reports]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SERPINC1 proteinDiseases associated with SERPINC1 protein
 Products by Pathway  Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 Thrombosis Antibodies  >26 publications with SERPINC1 and Thrombosis
 Antithrombin III Deficiency Antibodies  >24 publications with SERPINC1 and Antithrombin III Deficiency
 Blood Coagulation Disorders Antibodies  >23 publications with SERPINC1 and Blood Coagulation Disorders
 Vascular Diseases Antibodies  >21 publications with SERPINC1 and Vascular Diseases
 Cardiovascular Diseases Antibodies  >21 publications with SERPINC1 and Cardiovascular Diseases
 Venous Thrombosis Antibodies  >18 publications with SERPINC1 and Venous Thrombosis
 Thromboembolism Antibodies  >12 publications with SERPINC1 and Thromboembolism
 Venous Thromboembolism Antibodies  >8 publications with SERPINC1 and Venous Thromboembolism
 Stroke Antibodies  >5 publications with SERPINC1 and Stroke
 Weight Loss Antibodies  >3 publications with SERPINC1 and Weight Loss
Organs/Tissues associated with SERPINC1 protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with SERPINC1 and Liver
 Muscle Antibodies  >3 publications with SERPINC1 and Muscle
 Mammary Gland Antibodies  >1 publications with SERPINC1 and Mammary Gland
 Brain Antibodies  >1 publications with SERPINC1 and Brain
 Kidney Antibodies  >1 publications with SERPINC1 and Kidney
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