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APOA1 protein :: Apolipoprotein A1 Protein

Scan QR to view Datasheet Catalog #    MBS173020 APOA1 protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein A1 (APOA1), Protein

 Also Known As   

Apolipoprotein A1 Human Serum

 Product Synonym Names    Lipoproteins A1; apo A1; Apolipoprotein A1 (APO A1), Human Serum - >=96% (SDS-PAGE)
 Product Gene Name   

APOA1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 604091
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 Purity/Purification    >= 96% (SDS-PAGE)
 Form/Format    0.2 micron filtered solution in 50mM tris, 150mM Sodium chloride, 1mg/ml sodium azide, and 1mg/ml disodium EDTA, pH 7.4
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 Source    Human Serum
 UNSPSC Code    51131909
 Protein    0.9mg/ml (BCA)
 Preservatives    Sodium Azide
 pH    7.4
 Note    Product is soluble in aqueous buffers at low concentrations (<50ug/ml), but due to amphipathic nature, it will self-associate into oligomers at high concentrations in the absence of chaotropes (urea, guanine hydrochloride)
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of APOA1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for APOA1 protein

   Custom preparations, technical support, bulk quantities and aliquoting available.

Single polypeptide chain in 245 amino acids with high alpha-helical content, major structurual component of high density lipoproteins, cofactor for lecthin:cholesterol acyltransferase, levels in general are inversely related to risk of coronary artery disease in humans.

Human APO A1 is isolated by ultracentrifugation, delipidated and ion-exchange chromatography and is soluble in aqueous buffers at low concentrations (<50ug/mL) but due to amphipathic nature, APO A1 will self-associate into oligomers at high concentrations in the absence of chaotrupes (urea, guanidine hydrochloride).

Apo-AI comprises ~70% of the protein moiety in HDL. It is a single polypeptide chain consisting of 245 amino acids with glutamic acid as the C-terminal residue and aspartic acid as the N-terminal residue. The molecular mass is reported to be 28.3 kDa. The protein is made up of one major isoform (pI 5.6) and two minor isoforms (pI 5.53 and 5.46). Apo-AI shows a high content of -helix structure. The amphipathic regions in the -helix structure seem to be responsible for lipid binding capacity. In aqueous solution, Apo-AI shows self-association with minor conformation change. Apo-AI activates lecithin-cholesterol (LCAT) acyltransferase, which is responsible for cholesterol esterification in plasma.

Apo-AI levels in normal plasma are 90-130 mg/dL. Apo-AI levels may be inversely related to the risk of coronary disease.
 Product Categories/Family for APOA1 protein    Proteins; Antigens; Standards/controls; Native Proteins; Apolipoprotein A1 (apo A1)
NCBI/Uniprot data below describe general gene information for APOA1. It may not necessarily be applicable to this product.
 NCBI GI #    4557321
 NCBI GeneID    335
 NCBI Accession #    NP_000030.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000039.1 [Other Products]
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 UniProt Secondary Accession #    Q6LDN9; Q6Q785; Q9UCS8; Q9UCT8; A8K866 [Other Products]
 UniProt Related Accession #    P02647 [Other Products]
 Molecular Weight    28.3 kDa [Similar Products]
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 NCBI Official Full Name    apolipoprotein A-I preproprotein
 NCBI Official Synonym Full Names    apolipoprotein A-I
 NCBI Official Symbol    APOA1 [Similar Products]
 NCBI Protein Information    apolipoprotein A-I; apo-AI
 UniProt Protein Name    Apolipoprotein A-I
 UniProt Synonym Protein Names   
Apolipoprotein A1Cleaved into the following 2 chains:Proapolipoprotein A-I; ProapoA-I; Truncated apolipoprotein A-IAlternative name(s):Apolipoprotein A-I(1-242)
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOA1 [Similar Products]
 UniProt Synonym Gene Names    Apo-AI; ApoA-I; ProapoA-I [Similar Products]
 UniProt Entry Name    APOA1_HUMAN
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APOA1 proteinPathways associated with APOA1 protein
 Reference Product  PubMed Publications
 APOB protein  >482 publications with APOA1 and APOB
 ABCA1 protein  >130 publications with APOA1 and ABCA1
 APOC3 protein  >70 publications with APOA1 and APOC3
 CETP protein  >60 publications with APOA1 and CETP
 APOA2 protein  >40 publications with APOA1 and APOA2
 LCAT protein  >39 publications with APOA1 and LCAT
 ALB protein  >8 publications with APOA1 and ALB
 TTR protein  >7 publications with APOA1 and TTR
 FGA protein  >2 publications with APOA1 and FGA
 Products by Pathway  Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ABCA Transporters In Lipid Homeostasis Pathway antibodies  ABCA Transporters In Lipid Homeostasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
Diseases associated with APOA1 proteinOrgans/Tissues associated with APOA1 protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >442 publications with APOA1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >272 publications with APOA1 and Atherosclerosis
 Dyslipidemias Antibodies  >184 publications with APOA1 and Dyslipidemias
 Hyperlipidemias Antibodies  >125 publications with APOA1 and Hyperlipidemias
 Inflammation Antibodies  >107 publications with APOA1 and Inflammation
 Insulin Resistance Antibodies  >98 publications with APOA1 and Insulin Resistance
 Hypertension Antibodies  >77 publications with APOA1 and Hypertension
 Hypercholesterolemia Antibodies  >65 publications with APOA1 and Hypercholesterolemia
 Hypertriglyceridemia Antibodies  >58 publications with APOA1 and Hypertriglyceridemia
 Liver Diseases Antibodies  >52 publications with APOA1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >786 publications with APOA1 and Blood
 Liver Antibodies  >181 publications with APOA1 and Liver
 Heart Antibodies  >158 publications with APOA1 and Heart
 Muscle Antibodies  >34 publications with APOA1 and Muscle
 Brain Antibodies  >33 publications with APOA1 and Brain
 Lung Antibodies  >21 publications with APOA1 and Lung
 Ovary Antibodies  >15 publications with APOA1 and Ovary
 Intestine Antibodies  >15 publications with APOA1 and Intestine
 Pancreas Antibodies  >7 publications with APOA1 and Pancreas
 Embryonic Tissue Antibodies  >4 publications with APOA1 and Embryonic Tissue
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