NP_598738.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80.0 kDa
NCBI Official Full Name
serotransferrin
NCBI Official Synonym Full Names
transferrin
NCBI Official Synonym Symbols
HP; Tf; Tfn; hpx; Cd176; AI266983 [Similar Products]
NCBI Protein Information
serotransferrin
UniProt Protein Name
Serotransferrin
UniProt Synonym Protein Names
Beta-1 metal-binding globulin; Siderophilin
UniProt Synonym Gene Names
UniProt Entry Name
TRFE_MOUSE
UniProt Comments for TF
TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; basement membrane; vesicle; endosome
Molecular Function: protein binding; ferric iron binding; metal ion binding; ferric iron transmembrane transporter activity
Biological Process: positive regulation of myelination; iron ion homeostasis; transport; positive regulation of transcription, DNA-dependent; actin filament organization; positive regulation of bone resorption; ion transport; osteoclast differentiation; ferric iron transport; iron ion transport; activation of JNK activity; positive regulation of phosphorylation
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Products associated with TF protein
Pathways associated with TF protein
Diseases associated with TF protein
Organs/Tissues associated with TF protein
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