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GOT1 protein :: Aspartate Aminotransferase Protein

Scan QR to view Datasheet Catalog #    MBS173081 GOT1 protein
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 Product Name   

Aspartate Aminotransferase (GOT1), Protein

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 Also Known As   

Glutamate Oxaloacetate Transaminase (GOT); Aspartate Transferase (AST), Porcine Heart

 Product Synonym Names    Aspartate Transaminase; Glutamate Oxaloacetate; AST; GOT; sGOT; AspAT; ASAT; AAT; serum glutamic oxaloacetic transaminase; Aspartate Aminotransferase (AST, GOT), Porcine Heart - Ammonium Sulfate
 Product Gene Name   

GOT1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P00503
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 Purity/Purification    Purified
 Form/Format    Liquid
Appearance: Yellow/green suspension
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 Source    Porcine Heart
 EC Number
 Unit Definition    One unit will catalyze the transamination of one micromole of L-aspartate to alpha-ketoglutarate forming L-glutamate and oxaloacetate per minute at 37 degree C and pH 7.8.
 Specific Activity    Reported U/mg protein
 Recertification    1 year
 Protein    >= 5.0 mg protein/mL (Coomassie)
 Contaminants    CPK: <=0.1%, GPT/ALT: <=0.1%, LDH: <=0.01%, gGT: <=0.01%, ALP: <=0.01%
 CAS Number    9000-97-9
 Activity    1,500 - 2,500 U/mL (Dimension Clinical Chemistry System)
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 Preparation and Storage    2-8 degree C
 Other Notes    Small volumes of GOT1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GOT1 protein

   MyBioSource manufactures porcine heart Glutamate Oxaloacetate Transaminase (GOT)/Asparate Transferase (AST) for research, life science and manufacturing uses.

Custom preparations, technical support, bulk quantities and aliquoting available.

The blood test for aspartate aminotransferase is usually used to detect liver damage. It is often ordered in conjunction with another liver enzyme, alanine aminotransferase, or as part of a liver panel to screen for and/or help diagnose liver disorders. They are considered to be two of the most important tests to detect liver injury, although ALT is more specific than AST. Sometimes AST is compared directly to ALT and an AST/ALT ratio is calculated. This ratio may be used to distinguish between different causes of liver damage.
 Product Categories/Family for GOT1 protein    Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Aspartate Aminotransferase (ast; Got)
NCBI/Uniprot data below describe general gene information for GOT1. It may not necessarily be applicable to this product.
 NCBI GI #    3452380
 NCBI GeneID    2805
 NCBI Accession #    AAC32851.1 [Other Products]
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 UniProt Primary Accession #    P00503 [Other Products]
 UniProt Related Accession #    P17174 [Other Products]
 Molecular Weight    ~92,000
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 NCBI Official Full Name    glutamate oxaloacetate transaminase
 NCBI Official Synonym Full Names    glutamic-oxaloacetic transaminase 1, soluble
 NCBI Official Symbol    GOT1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    aspartate aminotransferase, cytoplasmic; transaminase A; aspartate transaminase 1; aspartate aminotransferase 1; growth-inhibiting protein 18; cysteine transaminase, cytoplasmic; glutamate oxaloacetate transaminase 1; cysteine aminotransferase, cytoplasmic
 UniProt Protein Name    Aspartate aminotransferase, cytoplasmic
 UniProt Synonym Protein Names   
Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A
 Protein Family    Aspartate aminotransferase
 UniProt Gene Name    GOT1 [Similar Products]
 UniProt Synonym Gene Names    cAspAT; cCAT [Similar Products]
 UniProt Entry Name    AATC_PIG
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 NCBI Summary for GOT1    Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GOT1    GOT1: Plays a key role in amino acid metabolism. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: EC; EC; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - arginine and proline; Transferase; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine

Chromosomal Location of Human Ortholog: 10q24.1-q25.1

Cellular Component: lysosome; cytoplasm; nerve terminal; cytosol; nucleus

Molecular Function: cysteine transaminase activity; carboxylic acid binding; phosphatidylserine decarboxylase activity; aspartate transaminase activity; pyridoxal phosphate binding

Biological Process: glutamate metabolic process; oxaloacetate metabolic process; glutamate catabolic process to aspartate; response to glucocorticoid stimulus; aspartate biosynthetic process; glucose metabolic process; pathogenesis; gluconeogenesis; 2-oxoglutarate metabolic process; methionine salvage; cellular response to insulin stimulus; glycerol biosynthetic process; sulfur amino acid metabolic process; fatty acid homeostasis; carbohydrate metabolic process; aspartate catabolic process; aspartate metabolic process; amino acid biosynthetic process; glutamate catabolic process to 2-oxoglutarate; polyamine metabolic process

Disease: Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1
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 Research Articles on GOT1    1. Alcohol consumption, smoking status, and metabolic syndrome impact on serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT), was determined.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GOT1 proteinDiseases associated with GOT1 protein
 Reference Product  PubMed Publications
 GOT2 protein  >7 publications with GOT1 and GOT2
 MDH1 protein  >5 publications with GOT1 and MDH1
 LDHB protein  >3 publications with GOT1 and LDHB
 LDHA protein  >2 publications with GOT1 and LDHA
 ASNS protein  >1 publications with GOT1 and ASNS
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with GOT1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >4 publications with GOT1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >4 publications with GOT1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >3 publications with GOT1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with GOT1 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >2 publications with GOT1 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with GOT1 and Liver Diseases
 Fatty Liver Antibodies  >2 publications with GOT1 and Fatty Liver
 Fibrosis Antibodies  >2 publications with GOT1 and Fibrosis
 Weight Gain Antibodies  >1 publications with GOT1 and Weight Gain
Organs/Tissues associated with GOT1 protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with GOT1 and Blood
 Liver Antibodies  >7 publications with GOT1 and Liver
 Brain Antibodies  >4 publications with GOT1 and Brain
 Lung Antibodies  >4 publications with GOT1 and Lung
 Heart Antibodies  >4 publications with GOT1 and Heart
 Intestine Antibodies  >4 publications with GOT1 and Intestine
 Muscle Antibodies  >3 publications with GOT1 and Muscle
 Thyroid Antibodies  >2 publications with GOT1 and Thyroid
 Spinal Cord Antibodies  >2 publications with GOT1 and Spinal Cord
 Stomach Antibodies  >1 publications with GOT1 and Stomach
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