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BAFF CD8a, Fusion Protein

Scan QR to view Datasheet Catalog #    MBS635238 BAFF CD8a, Fusion Protein protein
Unit / Price
0.025 mg  /  $775 +1 FREE 8GB USB
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 Product Name   

BAFF CD8a, Fusion Protein

 Also Known As   

BAFF CD8a, Fusion Protein (Biotin)

 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Host    CHO cells
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 Purity/Purification    Affinity Purified
Purified by affinity chromatography.
 Form/Format    Supplied as a liquid in FBS, 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% NaN3.
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 Molecular Structure    A soluble molecule consisting of 151 (VQGPEET...c-term) aminoacids of the extracellular domain of human BAFF fused to the extracellular domain (167aa) of murine CD8 alpha, with a predicted monomeric weight of 38.5 kd. A portion of the extracellular region of BAFF was truncated to eliminate a potential protease cleavage site.
 Functional Application    Human BAFF(trn)-muCD8 binds to human cell surface TACI/BCMA/BAFFR.
Human BAFF(trn)-muCD8/Biotin*l
 Transfectant Cell Line    CHO
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 Preparation and Storage    May be stored at 4 degree C. For long-term storage, aliquot and store at 4 degree C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of BAFF CD8a, Fusion Protein protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BAFF CD8a, Fusion Protein protein

   The human B cell activating factor (BAFF,TALL-1, Blys, THANK) and APRIL(a proliferation inducing ligand) are both type II molecules belonging to the TNF superfamily. They are expressed by non-B cells, and are down regulated by mitogenic stimulation(2). BAFF and APRIL bind to at least two receptors: TACI (transmembrane activator and CAML-interactor) and BCMA (B cell maturation antigen), both of which are restricted to B cells(3,4). Ligation of these receptors with recombinant BAFF dramatically increases IgM production by peripheral blood B cells(1). Recently a third receptor for BAFF (BAFF-R) was described(5). BAFF and BAFFR knockout mice have a reduced numbers of mature B cells in the periphery, however TACI and BCMA knockouts do not share this phenotype, suggesting that BAFF-R may the primary receptor for BAFF in mice(8,9,10). Cell surface BAFF can be proteolytically cleaved to form a soluble trimeric molecule(2). Levels of soluble BAFF correspond with levels of autoantibodies in Sjogren's Syndrome(11). Recombinant BAFF(trn)-muCD8 binds to human cell surface TACI/BCMA/BAFFR
 Product Categories/Family for BAFF CD8a, Fusion Protein protein    Molecular Biology; MB-Proteins
 Applications Tested/Suitable for BAFF CD8a, Fusion Protein protein   

ELISA (EL/EIA), Flow Cytometry (FC/FACS)

 Application Notes for BAFF CD8a, Fusion Protein protein    Suitable for use in Flow Cytometry and ELISA.
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 Molecular Weight    38.5kD [Similar Products]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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