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BMP2 protein :: Bone Morphogenetic Protein-2 Protein

Scan QR to view Datasheet Catalog #    MBS546125 BMP2 protein
Unit / Price
0.002 mg  /  $165 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,165 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bone Morphogenetic Protein-2 (BMP2), Protein

★Popular Item★
 Also Known As   

Recombinant Human Bone MorphogeneticProtein-2 (rHu BMP-2)

 Product Synonym Names    Bone Morphogenetic Protein-2; human BMP-2; Human Bone Morphogenetic Protein 2 (BMP-2)
 Product Gene Name   

BMP2 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (6748745..6760910). Location: 20p12
 OMIM    112261
 3D Structure    ModBase 3D Structure for P12643
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 Host    E Coli
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 Purity/Purification    >95% by SDS-PAGE and HPLC analyses.
 Form/Format    Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution containing 10mM sodium citrate pH 3.5.
Physical Appearance: Sterile FilteredWhite lyophilized (freeze-dried) powder.
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 Molecular Weight Information    Approximately 23.9 kDa, a single non-glycosylated polypeptide chain containing 209 amino acids.
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by the cytolysis of MC3T3-E1 cells is less than 50 ng/ml.
 Endotoxin Level    Less than 1EU/mg of rHuBMP-2 as determined by LAL method.
 Reconstitution    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.
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 Preparation and Storage    Store in room temperature.
 Other Notes    Small volumes of BMP2 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BMP2 protein

   BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease.
NCBI/Uniprot data below describe general gene information for BMP2. It may not necessarily be applicable to this product.
 NCBI GI #    4557369
 NCBI GeneID    650
 NCBI Accession #    NP_001191.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001200.2 [Other Products]
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 UniProt Primary Accession #    P12643 [Other Products]
 UniProt Related Accession #    P12643 [Other Products]
 Molecular Weight    44,702 Da [Similar Products]
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 NCBI Official Full Name    bone morphogenetic protein 2 preproprotein
 NCBI Official Synonym Full Names    bone morphogenetic protein 2
 NCBI Official Symbol    BMP2 [Similar Products]
 NCBI Official Synonym Symbols   
BDA2; BMP2A
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A
 UniProt Protein Name    Bone morphogenetic protein 2
 UniProt Synonym Protein Names   
Bone morphogenetic protein 2A
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP2 [Similar Products]
 UniProt Synonym Gene Names    BMP2A; BMP-2; BMP-2A [Similar Products]
 UniProt Entry Name    BMP2_HUMAN
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 NCBI Summary for BMP2    The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMP2    Function: Induces cartilage and bone formation.

Subunit structure: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN

By similarity. Ref.4

Subcellular location: Secreted.

Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Pharmaceutical use: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.

Sequence similarities: Belongs to the TGF-beta family.
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 Research Articles on BMP2    1. Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP2 proteinPathways associated with BMP2 protein
 Reference Product  PubMed Publications
 BMPR2 protein  >191 publications with BMP2 and BMPR2
 BMPR1A protein  >165 publications with BMP2 and BMPR1A
 SMAD4 protein  >87 publications with BMP2 and SMAD4
 BMPR1B protein  >53 publications with BMP2 and BMPR1B
 SMAD7 protein  >32 publications with BMP2 and SMAD7
 NOG protein  >9 publications with BMP2 and NOG
 ACVR2B protein  >7 publications with BMP2 and ACVR2B
 GREM2 protein  >5 publications with BMP2 and GREM2
 CHRD protein  >3 publications with BMP2 and CHRD
 SOSTDC1 protein  >2 publications with BMP2 and SOSTDC1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
Diseases associated with BMP2 proteinOrgans/Tissues associated with BMP2 protein
 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >520 publications with BMP2 and Bone Diseases
 Neoplasms Antibodies  >264 publications with BMP2 and Neoplasms
 Necrosis Antibodies  >99 publications with BMP2 and Necrosis
 Inflammation Antibodies  >80 publications with BMP2 and Inflammation
 Pain Antibodies  >42 publications with BMP2 and Pain
 Hypertrophy Antibodies  >39 publications with BMP2 and Hypertrophy
 Hypertension Antibodies  >36 publications with BMP2 and Hypertension
 Fibrosis Antibodies  >30 publications with BMP2 and Fibrosis
 Breast Neoplasms Antibodies  >29 publications with BMP2 and Breast Neoplasms
 Kidney Diseases Antibodies  >24 publications with BMP2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3789 publications with BMP2 and Bone
 Connective Tissue Antibodies  >591 publications with BMP2 and Connective Tissue
 Embryonic Tissue Antibodies  >423 publications with BMP2 and Embryonic Tissue
 Heart Antibodies  >177 publications with BMP2 and Heart
 Brain Antibodies  >147 publications with BMP2 and Brain
 Kidney Antibodies  >82 publications with BMP2 and Kidney
 Lung Antibodies  >66 publications with BMP2 and Lung
 Liver Antibodies  >64 publications with BMP2 and Liver
 Eye Antibodies  >58 publications with BMP2 and Eye
 Prostate Antibodies  >25 publications with BMP2 and Prostate
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