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CD56 Protein

Scan QR to view Datasheet Catalog #    MBS634928 CD56 protein
Unit / Price
0.1 mg  /  $655 +1 FREE 8GB USB
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 Product Name   

CD56, Protein

★Popular Item★
 Also Known As   

CD56 (NCAM-1, Neural Cell Adhesion Molecule)

 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Host    Embryonic chicken brain
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 Purity/Purification    Purified
Purified. When treated with Neurminidase, molecular weight is 140-180kD. A breakdown product of 160kD may also be visible.
 Form/Format    Supplied as a liquid in 15mM octylthioglucoside, sodium bicarbonate. No preservative added.
 Concentration    0.5 mg/ml (lot specific)
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of CD56 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD56 protein

   The neural cell adhesion molecule (NCAM) was the first cell-cell adhesion molecule to be identified, isolated, and sequenced. Structurally, the extracellular portion of NCAM is comprised of five IgG-like domains followed by two fibronectin type III repeats. Because of its history, NCAM is considered to be the classic example of the family of cell-cell adhesion molecules that are structurally related to immunoglobulins. There are three forms of NCAM molecules that differ in their mode of attachment to the plasma membrane: ld, transmembrane form with large cytoplasmic domain; sd,transmembrane form with small cytoplasmic domain; ssd, GPI linked to the external surface of the plasma membrane. NCAM is unique in that the molecule can bear large oligosaccharides containing long chains of polysialic acid.

Functionally, NCAM mediates cell-cell adhesion both in neural cells and a variety of other cell types. NCAM-mediated adhesion occurs by both a homophilic mechanism (NCAM to NCAM) and a heterophilic mechanism in which NCAM binds to heparin sulfate proteoglycans. The polysialic acid in NCAM interferes with NCAMmediated cell-cell adhesion. Moreover, the polysialic acid on NCAM fills up so much of the space between cells that it also interferes with cell-cell adhesion mediated by other adhesion molecules. It has been suggested that the polysialic acid on NCAM is involved in maintaining plasticity in interactions among neural cells. NCAM is expressed at a wide variety of sites during embryonic development both in the nervous system and other tissues. Its expression is more restricted in the adult brain; however, it is still expressed in certain regions. NCAM expression is also associated with certain diseases. In particular, it is considered to be a marker for Wilms tumor and for small cell lung carcinoma. NCAM is derived from embryonic chicken brains and is composed of polysialic acid-rich molecules. Neuraminidase treatment of the preparation reveals that it contains mainly the ld form of NCAM with a smaller amount of the sd form.
When treated with Neurminidase, molecular weight is 140-180kD. A breakdown product of 160kD may also be visible.
 Product Categories/Family for CD56 protein    Molecular Biology; MB-CD Markers
NCBI/Uniprot data below describe general gene information for CD56. It may not necessarily be applicable to this product.
 NCBI GI #    158524860
 NCBI Accession #    ABW71276.1 [Other Products]
 Molecular Weight    200-250kD [Similar Products]
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 NCBI Official Full Name    CD56
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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