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CP protein :: Ceruloplasmin Protein

Scan QR to view Datasheet Catalog #    MBS173049 CP protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ceruloplasmin (CP), Protein

 Also Known As   

Ceruloplasmin, Rat Serum

 Product Synonym Names    Ceruloplasmin (Cp), Rat
 Product Gene Name   

CP protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 604290
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 Form/Format    Liquid
 Concentration    Protein Concentration: Typically >0.5 mg/mL (lot specific)
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 Source    Rat Serum
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of CP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CP protein

   Bulk quantities of Rat Ceruloplasmin available in 10-100 mg lot sizes.

Custom preparations, technical support, bulk quantities and aliquoting available.

Rat Ceruloplasmin is an approximately 120 kDa monomeric serum protein that fuctions as a copper transporter. It is a positive acute phase reactant, the levels of which increase significantly in rats in response to inflammation, tissue injury and disease.
 Product Categories/Family for CP protein    Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Ceruloplasmin (cp)
NCBI/Uniprot data below describe general gene information for CP. It may not necessarily be applicable to this product.
 NCBI GI #    1731685
 NCBI GeneID    1356
 NCBI Accession #    BAA08085.1 [Other Products]
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 UniProt Secondary Accession #    Q14063; Q2PP18; Q9UKS4 [Other Products]
 UniProt Related Accession #    P00450 [Other Products]
 Molecular Weight    122,205 Da [Similar Products]
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 NCBI Official Full Name    ceruloplasmin, partial
 NCBI Official Synonym Full Names    ceruloplasmin (ferroxidase)
 NCBI Official Symbol    CP [Similar Products]
 NCBI Official Synonym Symbols   
CP-2
[Similar Products]
 NCBI Protein Information    ceruloplasmin
 UniProt Protein Name    Ceruloplasmin
 UniProt Synonym Protein Names   
Ferroxidase
 Protein Family    Ceruloplasmin
 UniProt Gene Name    CP [Similar Products]
 UniProt Entry Name    CERU_HUMAN
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 NCBI Summary for CP    The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for CP    CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family.

Protein type: Secreted, signal peptide; Secreted; EC 1.16.3.1; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase

Chromosomal Location of Human Ortholog: 3q23-q25

Cellular Component: extracellular space; lysosomal membrane; extracellular region

Molecular Function: ferroxidase activity; copper ion binding; chaperone binding

Biological Process: cellular iron ion homeostasis; copper ion transport; transmembrane transport

Disease: Aceruloplasminemia
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 Research Articles on CP    1. The core-fucosylation ratio of ceruloplasmin increases significantly in alcohol-related hepatocellular carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CP proteinPathways associated with CP protein
 Reference Product  PubMed Publications
 ALB protein  >49 publications with CP and ALB
 HIF1A protein  >18 publications with CP and HIF1A
 ATP7A protein  >9 publications with CP and ATP7A
 HBB protein  >6 publications with CP and HBB
 ANXA2 protein  >5 publications with CP and ANXA2
 SLC40A1 protein  >4 publications with CP and SLC40A1
 ARNT protein  >2 publications with CP and ARNT
 SLC11A2 protein  >1 publications with CP and SLC11A2
 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Metal Ion SLC Transporters Pathway antibodies  Metal Ion SLC Transporters Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
Diseases associated with CP proteinOrgans/Tissues associated with CP protein
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4124 publications with CP and Brain Diseases
 Pain Antibodies  >1665 publications with CP and Pain
 Disease Models, Animal Antibodies  >1453 publications with CP and Disease Models, Animal
 Inflammation Antibodies  >1305 publications with CP and Inflammation
 Necrosis Antibodies  >747 publications with CP and Necrosis
 Diabetes Mellitus Antibodies  >655 publications with CP and Diabetes Mellitus
 Ischemia Antibodies  >624 publications with CP and Ischemia
 Lung Neoplasms Antibodies  >618 publications with CP and Lung Neoplasms
 Hypertension Antibodies  >552 publications with CP and Hypertension
 Kidney Diseases Antibodies  >534 publications with CP and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8519 publications with CP and Blood
 Brain Antibodies  >3723 publications with CP and Brain
 Muscle Antibodies  >3039 publications with CP and Muscle
 Liver Antibodies  >2087 publications with CP and Liver
 Bone Antibodies  >2035 publications with CP and Bone
 Lung Antibodies  >1500 publications with CP and Lung
 Vascular Antibodies  >1485 publications with CP and Vascular
 Kidney Antibodies  >1123 publications with CP and Kidney
 Intestine Antibodies  >1116 publications with CP and Intestine
 Nerve Antibodies  >1024 publications with CP and Nerve
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