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C4c protein :: Complement Component 4c Protein

Scan QR to view Datasheet Catalog #    MBS173069 C4c protein
Unit / Price
0.1 mg  /  $155 +1 FREE 8GB USB
1 mg  /  $230 +1 FREE 8GB USB
10 mg  /  $1,110 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement Component 4c (C4c), Protein

 Also Known As   

Complement C4c (C4c), Human Plasma

 Product Synonym Names    C4; Complement Component 4 (C4), >95% (SDS-PAGE) - Liquid
 Product Gene Name   

C4c protein

[Similar Products]
 Product Synonym Gene Name    DAMC-258G8.6; C4; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; CPAMD2; RG; DADB-112B14.11-001; C4B1; C4B12; C4B2; C4B3; C4B5; C4BD; C4B_2; C4F; CH; CO4; CPAMD3; C4B [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120830
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 Purity/Purification    > 95% (SDS-PAGE)
 Form/Format    Liquid
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 Source    Human Plasma
 Recertification    3 years
 Protein    >= 1.0 mg/mL (A280 E=0.92)
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of C4c protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for C4c protein

   MyBioSource sells Human Complement C4 (C4) for research and diagnostic manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human Complement proteins: It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis.

Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis).
 Product Categories/Family for C4c protein    Proteins; Antigens; Standards/controls; Native Proteins; Complement Component 4 (c4)
 Applications Tested/Suitable for C4c protein   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for C4c. It may not necessarily be applicable to this product.
 NCBI GeneID    722
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 UniProt Secondary Accession #    Q5VVQ8 [Other Products]
 Molecular Weight    67,033 Da
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 NCBI Official Full Name    Complement component 4 binding protein, alpha
 NCBI Official Synonym Full Names    complement component 4 binding protein, alpha
 NCBI Official Symbol    C4BPA [Similar Products]
 NCBI Official Synonym Symbols   
PRP; C4BP
[Similar Products]
 NCBI Protein Information    C4b-binding protein alpha chain; proline-rich protein
 UniProt Protein Name    C4b-binding protein alpha chain
 UniProt Synonym Protein Names   
Proline-rich protein; PRP
 UniProt Gene Name    C4BPA [Similar Products]
 UniProt Synonym Gene Names    C4BP; C4bp; PRP [Similar Products]
 UniProt Entry Name    C4BPA_HUMAN
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 NCBI Summary for C4c    This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C4c    C4BPA: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; plasma membrane; extracellular region

Molecular Function: protein binding

Biological Process: negative regulation of complement activation, classical pathway; regulation of complement activation; positive regulation of protein catabolic process; innate immune response; complement activation, classical pathway
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 Research Articles on C4c    1. these data suggest that when C4BP is bound to Ail, fI can cleave and inactivate C4b that has bound covalently to bacterial surface structures as well as C4b bound noncovalently to Ail.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with C4c protein
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
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