AAA96609.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
creatine kinase
NCBI Official Synonym Full Names
creatine kinase, muscle
NCBI Official Synonym Symbols
NCBI Protein Information
creatine kinase M-type; creatine kinase-M; creatine kinase M chain
UniProt Protein Name
Creatine kinase M-type
UniProt Synonym Protein Names
Creatine kinase M chain; M-CK
UniProt Synonym Gene Names
UniProt Entry Name
KCRM_HUMAN
NCBI Summary for CKM
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq]
UniProt Comments for CKM
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Catalytic activity: ATP + creatine = ADP + phosphocreatine.
Subunit structure: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
Subcellular location: Cytoplasm.
Sequence similarities: Belongs to the ATP:guanido phosphotransferase family.Contains 1 phosphagen kinase C-terminal domain.Contains 1 phosphagen kinase N-terminal domain.
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Products associated with CKM active protein
Pathways associated with CKM active protein
Diseases associated with CKM active protein
Organs/Tissues associated with CKM active protein
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