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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

EPX protein :: Eosinophil Peroxidase Protein

Scan QR to view Datasheet Catalog #    MBS173121 EPX protein
Unit / Price
0.025 mg  /  $200 +1 FREE 8GB USB
0.1 mg  /  $510 +1 FREE 8GB USB
0.5 mg  /  $1,820 +2 FREE 8GB USB
1 mg  /  $2,410 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Eosinophil Peroxidase (EPX), Protein

★Popular Item★
 Also Known As   

Eosinophil Peroxidase (EPO), Human

 Product Synonym Names    EPO
 Product Gene Name   

EPX protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 261500
 3D Structure    ModBase 3D Structure for P11678
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 Purity/Purification    > 98% (SDS-PAGE)
 Form/Format    0.2 micron filtered solution in 0.1M sodium phosphate with 0.4M sodium chloride, pH 7.5
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 Source    Human Eosinophils
 EC Number    1.11.1.7
 Appearance    Clear, green to brown liquid
 Unit Definition    One unit of eosinophil peroxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 degree C.
 Specific Activity    1,400 units/mg protein
 Enzymatic Activity    1,100 units/mL
 RZ Value    1.1 (A280/A413)
 Protein    0.8 mg protein/mL (Coomassie)
 CAS Number    9003-99-0
 Handling    Handle as a potentially hazardous substance.
 Recovery    Microfuge vial before drawing from container.
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 Preparation and Storage    Store at 2-8 degree C
Do not freeze.
 Other Notes    Small volumes of EPX protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for EPX protein    Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Immunogen; Eosinophil Peroxidase (epo)
NCBI/Uniprot data below describe general gene information for EPX. It may not necessarily be applicable to this product.
 NCBI GI #    4503595
 NCBI GeneID    8288
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 UniProt Primary Accession #    P11678 [Other Products]
 UniProt Secondary Accession #    Q4TVP3 [Other Products]
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 NCBI Official Full Name    eosinophil peroxidase preproprotein
 NCBI Official Synonym Full Names    eosinophil peroxidase
 NCBI Official Symbol    EPX [Similar Products]
 NCBI Official Synonym Symbols   
EPO; EPP; EPXD; EPX-PEN
[Similar Products]
 NCBI Protein Information    eosinophil peroxidase
 UniProt Protein Name    Eosinophil peroxidase
 Protein Family    Eosinophil peroxidase
 UniProt Gene Name    EPX [Similar Products]
 UniProt Synonym Gene Names    EPER; EPO; EPP; EPO [Similar Products]
 UniProt Entry Name    PERE_HUMAN
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 UniProt Comments for EPX    EPX: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD). EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining. Belongs to the peroxidase family. XPO subfamily.

Protein type: Oxidoreductase; EC 1.11.1.7

Chromosomal Location of Human Ortholog: 17q23.1

Molecular Function: peroxidase activity; metal ion binding; heme binding

Biological Process: positive regulation of interleukin-4 production; negative regulation of interleukin-10 production; hydrogen peroxide catabolic process; negative regulation of interleukin-5 production; response to oxidative stress; defense response to nematode

Disease: Eosinophil Peroxidase Deficiency
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 Research Articles on EPX    1. A preferential role of EPO signaling via a specific surface receptor that leads to neural plasticity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EPX proteinDiseases associated with EPX protein
 Reference Product  PubMed Publications
 CCL11 protein  >4 publications with EPX and CCL11
 RNASE3 protein  >4 publications with EPX and RNASE3
 CCR3 protein  >2 publications with EPX and CCR3
 CAT protein  >1 publications with EPX and CAT
 IL5 protein  >1 publications with EPX and IL5
 RNASE2 protein  >1 publications with EPX and RNASE2
 Disease Name  Pubmed Publications
 Respiratory Tract Diseases Antibodies  >90 publications with EPX and Respiratory Tract Diseases
 Asthma Antibodies  >89 publications with EPX and Asthma
 Inflammation Antibodies  >85 publications with EPX and Inflammation
 Lung Diseases Antibodies  >77 publications with EPX and Lung Diseases
 Skin Diseases Antibodies  >24 publications with EPX and Skin Diseases
 Eosinophilia Antibodies  >23 publications with EPX and Eosinophilia
 Heart Diseases Antibodies  >9 publications with EPX and Heart Diseases
 Respiratory Sounds Antibodies  >8 publications with EPX and Respiratory Sounds
 Bronchial Hyperreactivity Antibodies  >8 publications with EPX and Bronchial Hyperreactivity
 Fibrosis Antibodies  >7 publications with EPX and Fibrosis
Organs/Tissues associated with EPX protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >162 publications with EPX and Blood
 Bone Antibodies  >7 publications with EPX and Bone
 Bone Marrow Antibodies  >6 publications with EPX and Bone Marrow
 Mixed Antibodies  >1 publications with EPX and Mixed
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