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Factor Xa, BEGR Protein

Scan QR to view Datasheet Catalog #    MBS634686 Factor Xa, BEGR protein
Unit / Price
0.1 mg  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Factor Xa, BEGR, Protein

★Popular Item★
 Also Known As   

Factor Xa, BEGR (Biotin-EGR), Human

 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Host    Human Plasma
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 Purity/Purification    Highly Purified
>95% (SDS-PAGE)
 Form/Format    Supplied as a liquid 20mM Hepes, pH 7.4, 150mM sodium chloride.
 Concentration    2.3mg/ml (lot specific)
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 Specific Activity    ~1000u/mg
 Extinction Coefficient    E1%1cm, 280nm= 11.6 (6)
 Mode of Action    Enzyme component of the prothrombinase complex
 Structure    Two subunits, Mr=16,200 and 29,000 (6), NH2-terminal gla domain, two EGF domains
 Percent Carbohydrate    3.0% (8)
 Post-translational Modifications    Eleven gla residues, one beta-hydroxyaspartate
 Localization    Plasma
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of Factor Xa, BEGR protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Factor Xa, BEGR protein

   Activation of the zymogen, factor X, by either the intrinsic or extrinsic factor Xase complexes produces the active serine protease factor Xa (1,2). The activation of factor X requires proteolytic cleavage of the heavy chain, resulting in the release of an activation glycopeptide. The heavy chain region in factor Xa contains the serine protease catalytic domain, while the light chain, as in the zymogen, contains the membrane binding domain.

Factor Xa participates in the prothrombinase complex, which catalyzes the rapid conversion of prothrombin to thrombin. Protothrombinase is an enzyme complex composed of factor Xa (enzyme) and factor Va (cofactor) assembled on a cellular suface in the presence of calcium ions. Although factor Xa can independently catalyze the activation o prothrombin, the rate at which this reaction occurs is increased nearly 300,000-fold with complete assembly of the prothrombinase complex. The clotting activity of factor Xa in vivo is terminated by wither inactivation of the cofactor, factor Va, or by direct inhibition of factor Xa by inhibitors, such as ATIII, after disassembly of the prothrombinase complex.
 Product Categories/Family for Factor Xa, BEGR protein    Molecular Biology; MB-Coagulation Factors
 Molecular Weight    46,000 [Similar Products]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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