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FN1 protein :: Fibronectin Protein

Scan QR to view Datasheet Catalog #    MBS135715 FN1 protein
Unit / Price
1 mg  /  $395 +1 FREE 8GB USB
10 mg  /  $2,700 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibronectin (FN1), Protein

★Popular Item★
 Also Known As   

Mouse Fibronectin

 Product Gene Name   

FN1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000067.6 (71585523..71653171, complement). Location: 1 C1-C5; 1 36.05 cM
 3D Structure    ModBase 3D Structure for P11276
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 Host    Mouse plasma
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 Purity/Purification    >95% by SDS-PAGE analysis
 Form/Format    Frozen liquid
 Concentration    1.0 mg/ml (lot specific)
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 Buffer    0.1 M Tris-HCl; 0.15 M NaCl; pH 7.4
 Extinction Coefficient    1.28
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 3 years from delivery
 Other Notes    Small volumes of FN1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FN1 protein

   Prepared from fresh mouse plasma. Ideal reagent for tissue culture studies and protein-protein interactions. Thaw the fibronectin by placing the vial in a 37 C water bath and leaving it undisturbed until completely thawed. Do not disturb the vial at any time during the thawing process. If the vial is disturbed or removed prior to complete thawing, the fibronectin will form a gel and be unusable. Mix very gently with pipette after thawing. Vortexing, excessive agitation, repeated freezing and thawing of fibronectin are not recommended.
 Product Categories/Family for FN1 protein    Fibronectin; Mouse Fibronectin
NCBI/Uniprot data below describe general gene information for FN1. It may not necessarily be applicable to this product.
 NCBI GI #    46849812
 NCBI GeneID    14268
 NCBI Accession #    NP_034363.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010233.2 [Other Products]
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 UniProt Primary Accession #    P11276 [Other Products]
 UniProt Secondary Accession #    Q61567; Q61568; Q61569; Q64233; Q80UI4; G5E8B8 [Other Products]
 UniProt Related Accession #    P11276 [Other Products]
 Molecular Weight    220,000
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 NCBI Official Full Name    fibronectin isoform a
 NCBI Official Synonym Full Names    fibronectin 1
 NCBI Official Symbol    Fn1 [Similar Products]
 NCBI Official Synonym Symbols   
Fn; Fn-1; E330027I09
[Similar Products]
 NCBI Protein Information    fibronectin
 UniProt Protein Name    Fibronectin
 Protein Family    Fibronectin
 UniProt Gene Name    Fn1 [Similar Products]
 UniProt Synonym Gene Names    FN [Similar Products]
 UniProt Entry Name    FINC_MOUSE
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 UniProt Comments for FN1    FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Cell adhesion; Secreted, signal peptide

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; fibrinogen complex; apical plasma membrane; ER-Golgi intermediate compartment; extracellular region; basement membrane; basal lamina

Molecular Function: heparin binding; integrin binding; protein binding; protease activator activity; protease binding; mercury ion binding

Biological Process: integrin activation; extracellular matrix organization and biogenesis; wound healing; positive regulation of chemotaxis; cell-matrix adhesion; positive regulation of axon extension; glial cell migration; cell activation; regulation of cell shape; calcium-independent cell-matrix adhesion; acute-phase response; cell-substrate junction assembly; peptide cross-linking; angiogenesis; cell adhesion; positive regulation of cell migration; negative regulation of apoptosis
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 Research Articles on FN1    1. RhoA activates NFAT by inducing a rise of [Ca(2+)]i in podocytes, which in turn contributes to fibronectin upregulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FN1 proteinDiseases associated with FN1 protein
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Fibronectin Matrix Formation Pathway antibodies  Fibronectin Matrix Formation Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >77 publications with FN1 and Neoplasms
 Carcinoma Antibodies  >48 publications with FN1 and Carcinoma
 Nervous System Diseases Antibodies  >15 publications with FN1 and Nervous System Diseases
 Fibrosis Antibodies  >15 publications with FN1 and Fibrosis
 Inflammation Antibodies  >13 publications with FN1 and Inflammation
 Neoplasms, Experimental Antibodies  >13 publications with FN1 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >11 publications with FN1 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >10 publications with FN1 and Lung Neoplasms
 Kidney Diseases Antibodies  >8 publications with FN1 and Kidney Diseases
 Diabetes Mellitus Antibodies  >8 publications with FN1 and Diabetes Mellitus
Organs/Tissues associated with FN1 protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with FN1 and Blood
 Bone Antibodies  >18 publications with FN1 and Bone
 Muscle Antibodies  >17 publications with FN1 and Muscle
 Kidney Antibodies  >17 publications with FN1 and Kidney
 Lung Antibodies  >17 publications with FN1 and Lung
 Embryonic Tissue Antibodies  >17 publications with FN1 and Embryonic Tissue
 Brain Antibodies  >15 publications with FN1 and Brain
 Skin Antibodies  >12 publications with FN1 and Skin
 Liver Antibodies  >12 publications with FN1 and Liver
 Connective Tissue Antibodies  >12 publications with FN1 and Connective Tissue
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