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FN1 protein :: Fibronectin Protein

Scan QR to view Datasheet Catalog #    MBS135795 FN1 protein
Unit / Price
1 mg  /  $235 +1 FREE 8GB USB
10 mg  /  $1,405 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibronectin (FN1), Protein

 Also Known As   

Human Fibronectin

 Product Gene Name   

FN1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (216225177..216300791, complement). Location: 2q34
 OMIM    135600
 3D Structure    ModBase 3D Structure for P02751
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 Host    Human plasma
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 Purity/Purification    >95% by SDS-PAGE analysis
 Form/Format    Frozen liquid
 Concentration    10.0 mg/ml (lot specific)
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 Buffer    0.1 M Tris-Cl; 0.15 M NaCl; pH 7.4
 Extinction Coefficient    1.28
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 3 years from delivery
 Other Notes    Small volumes of FN1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FN1 protein

   Prepared from fresh human plasma. Ideal reagent for tissue culture studies and protein-protein interactions. Thaw the fibronectin by placing the vial in a 37 C water bath and leaving it undisturbed until completely thawed. Do not disturb the vial at any t
 Product Categories/Family for FN1 protein    Fibronectin; Human Fibronectin
NCBI/Uniprot data below describe general gene information for FN1. It may not necessarily be applicable to this product.
 NCBI GI #    16933542
 NCBI GeneID    2335
 NCBI Accession #    NP_002017.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002026.2 [Other Products]
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 UniProt Primary Accession #    P02751 [Other Products]
 UniProt Secondary Accession #    O95609; O95610; Q14312; Q14325; Q14326; Q17RV7; Q585T2; Q59EH1; Q60FE4; Q68DP8; Q68DP9 [Other Products]
 UniProt Related Accession #    P02751 [Other Products]
 Molecular Weight    220,000
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 NCBI Official Full Name    fibronectin isoform 3 preproprotein
 NCBI Official Synonym Full Names    fibronectin 1
 NCBI Official Symbol    FN1 [Similar Products]
 NCBI Official Synonym Symbols   
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2
[Similar Products]
 NCBI Protein Information    fibronectin; cold-insoluble globulin; migration-stimulating factor
 UniProt Protein Name    Fibronectin
 UniProt Synonym Protein Names   
Cold-insoluble globulin
 Protein Family    Fibronectin
 UniProt Gene Name    FN1 [Similar Products]
 UniProt Synonym Gene Names    FN; FN; CIG [Similar Products]
 UniProt Entry Name    FINC_HUMAN
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 NCBI Summary for FN1    This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FN1    FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cell adhesion; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: extracellular matrix; extracellular space; apical plasma membrane; fibrinogen complex; extracellular region; ER-Golgi intermediate compartment; basal lamina

Molecular Function: collagen binding; heparin binding; integrin binding; protein binding; protease activator activity; protease binding

Biological Process: integrin activation; platelet activation; extracellular matrix organization and biogenesis; positive regulation of axon extension; regulation of cell shape; extracellular matrix disassembly; platelet degranulation; acute-phase response; response to wounding; calcium-independent cell-matrix adhesion; cell-substrate junction assembly; peptide cross-linking; angiogenesis; cell adhesion; blood coagulation; leukocyte migration

Disease: Glomerulopathy With Fibronectin Deposits 2; Plasma Fibronectin Deficiency
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 Research Articles on FN1    1. The interaction of TNC with immobilized FN was attenuated, the scratch wound closure by keratinocytes was delayed and the inhibition of cell spreading on FN by TNC was recovered in the presence of SSL8.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FN1 proteinPathways associated with FN1 protein
 Reference Product  PubMed Publications
 COL1A1 protein  >18 publications with FN1 and COL1A1
 SPARC protein  >10 publications with FN1 and SPARC
 COL1A2 protein  >9 publications with FN1 and COL1A2
 COL2A1 protein  >5 publications with FN1 and COL2A1
 ITGA5 protein  >5 publications with FN1 and ITGA5
 COL4A1 protein  >4 publications with FN1 and COL4A1
 TNC protein  >4 publications with FN1 and TNC
 THBS1 protein  >4 publications with FN1 and THBS1
 MMP9 protein  >4 publications with FN1 and MMP9
 ITGB1 protein  >4 publications with FN1 and ITGB1
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Fibronectin Matrix Formation Pathway antibodies  Fibronectin Matrix Formation Pathway Diagram
Diseases associated with FN1 proteinOrgans/Tissues associated with FN1 protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >77 publications with FN1 and Neoplasms
 Carcinoma Antibodies  >48 publications with FN1 and Carcinoma
 Nervous System Diseases Antibodies  >15 publications with FN1 and Nervous System Diseases
 Fibrosis Antibodies  >15 publications with FN1 and Fibrosis
 Inflammation Antibodies  >13 publications with FN1 and Inflammation
 Neoplasms, Experimental Antibodies  >13 publications with FN1 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >11 publications with FN1 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >10 publications with FN1 and Lung Neoplasms
 Kidney Diseases Antibodies  >8 publications with FN1 and Kidney Diseases
 Diabetes Mellitus Antibodies  >8 publications with FN1 and Diabetes Mellitus
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with FN1 and Blood
 Bone Antibodies  >18 publications with FN1 and Bone
 Muscle Antibodies  >17 publications with FN1 and Muscle
 Lung Antibodies  >17 publications with FN1 and Lung
 Embryonic Tissue Antibodies  >17 publications with FN1 and Embryonic Tissue
 Kidney Antibodies  >17 publications with FN1 and Kidney
 Brain Antibodies  >15 publications with FN1 and Brain
 Liver Antibodies  >12 publications with FN1 and Liver
 Skin Antibodies  >12 publications with FN1 and Skin
 Vascular Antibodies  >12 publications with FN1 and Vascular
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