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GFAP protein :: Glial Fibrillary Acidic Protein

Scan QR to view Datasheet Catalog #    MBS664036 GFAP protein
Unit / Price
0.1 mg  /  $645 +1 FREE 8GB USB
0.5 mg  /  $1,180 +1 FREE 8GB USB
1 mg  /  $1,630 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glial Fibrillary Acidic Protein (GFAP), Protein

 Also Known As   

Glial fibrillary acidic protein (GFAP)

 Product Gene Name   

GFAP protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 203450
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 Purity/Purification    Two-staged tissue extraction, hydroxyapatite chromatography.
 Form/Format    Lyophilised from 16 mM NaHCO3, pH 8.5.
Product is recommended to reconstitute with distilled water.
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 Source Note    Human brain.
Blood sample from the tissue donor was tested and found negative for HbsAg, HIV-1 and HIV-2 antibodies, HCV, and syphilis.
 Analysis    Purity > 90 % (SDS-PAGE). GFAP preparations are represented by several 43-49 kDa protein bands. The major two bands appear in the region of 46 kDa.
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of GFAP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for GFAP protein   

ELISA (EIA)

 Application Notes for GFAP protein    Verified in ELISA using anti-GFAP antibodies.
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NCBI/Uniprot data below describe general gene information for GFAP. It may not necessarily be applicable to this product.
 NCBI GI #    251802
 NCBI GeneID    2670
 NCBI Accession #    AAB22581.1 [Other Products]
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 UniProt Secondary Accession #    Q53H98; Q5D055; Q6ZQS3; Q7Z5J6; Q7Z5J7; Q96KS4; Q96P18; Q9UFD0; B2RD44; D3DX59; E9PAX3 [Other Products]
 UniProt Related Accession #    P14136 [Other Products]
 Molecular Weight    49,508 Da
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 NCBI Official Full Name    glial fibrillary acidic protein
 NCBI Official Synonym Full Names    glial fibrillary acidic protein
 NCBI Official Symbol    GFAP [Similar Products]
 NCBI Protein Information    glial fibrillary acidic protein
 UniProt Protein Name    Glial fibrillary acidic protein
 Protein Family    Glial fibrillary acidic protein
 UniProt Gene Name    GFAP [Similar Products]
 UniProt Synonym Gene Names    GFAP [Similar Products]
 UniProt Entry Name    GFAP_HUMAN
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 NCBI Summary for GFAP    This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
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 UniProt Comments for GFAP    GFAP: a class-III intermediate filament protein. A cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant isoform has been described, but its full length sequence has not been determined.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: membrane; cytoplasm; intermediate filament; cytosol

Molecular Function: integrin binding; structural constituent of cytoskeleton; kinase binding

Biological Process: extracellular matrix organization and biogenesis; Bergmann glial cell differentiation; regulation of neurotransmitter uptake; response to wounding; intermediate filament organization; neurite regeneration; astrocyte development

Disease: Alexander Disease
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 Research Articles on GFAP    1. This stuidy demonistrated that Fibrillary astrocytes are decreased in the subgenual cingulate in schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GFAP proteinDiseases associated with GFAP protein
 Products by Pathway  Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By ERBB4 Pathway antibodies  Signaling By ERBB4 Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4881 publications with GFAP and Nervous System Diseases
 Brain Diseases Antibodies  >3687 publications with GFAP and Brain Diseases
 Disease Models, Animal Antibodies  >1424 publications with GFAP and Disease Models, Animal
 Gliosis Antibodies  >1105 publications with GFAP and Gliosis
 Cardiovascular Diseases Antibodies  >873 publications with GFAP and Cardiovascular Diseases
 Brain Injuries Antibodies  >695 publications with GFAP and Brain Injuries
 Inflammation Antibodies  >629 publications with GFAP and Inflammation
 Necrosis Antibodies  >565 publications with GFAP and Necrosis
 Nerve Degeneration Antibodies  >540 publications with GFAP and Nerve Degeneration
 Epilepsy Antibodies  >364 publications with GFAP and Epilepsy
Organs/Tissues associated with GFAP protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7843 publications with GFAP and Brain
 Nerve Antibodies  >3382 publications with GFAP and Nerve
 Blood Antibodies  >1581 publications with GFAP and Blood
 Spinal Cord Antibodies  >1380 publications with GFAP and Spinal Cord
 Eye Antibodies  >992 publications with GFAP and Eye
 Muscle Antibodies  >515 publications with GFAP and Muscle
 Ganglia Antibodies  >295 publications with GFAP and Ganglia
 Bone Marrow Antibodies  >252 publications with GFAP and Bone Marrow
 Liver Antibodies  >206 publications with GFAP and Liver
 Connective Tissue Antibodies  >185 publications with GFAP and Connective Tissue
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