Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Protein rightarrow CSF2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • PLAU-uPA ELISA Kit
 • MD-2 Antibody
 • NOX4 Antibody
 • A Disintegrin and Metalloprotease 22 (ADAM22) ELISA Kit
 • Phaseolus vulgaris E Lectin
 • GSK-3 beta (GSK3B) Antibody
 • Arginase 1 (Liver type) (Arg1) ELISA Kit
 • Agrin ELISA Kit
 • NCALD Antibody
 • par-3 partitioning defective 3 homolog Antibody
 • Activation-induced Cytidine Deaminase (AICDA) Antibody
 • EPO ELISA Kit
 • E3 ubiquitin-protein ligase XIAP (xiap) Recombinant Protein
 • TBX22 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

CSF2 protein :: Granulocyte Macrophage Colony Stimulating Factor Protein

Scan QR to view Datasheet Catalog #    MBS546106 CSF2 protein
Unit / Price
0.005 mg  /  $165 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,150 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Granulocyte Macrophage Colony Stimulating Factor (CSF2), Protein

 Also Known As   

Recombinant Human GranulocyteMacrophage Colony Stimulating Factor (rHu GM-CSF)

 Product Synonym Names    Granulocyte Macrophage Colony Stimulating Factor; human GM-CSF; Human Granulocyte-Macrophage Colony Stimulating Factor
 Product Gene Name   

CSF2 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 5; NC_000005.9 (131409485..131411863). Location: 5q31.1
 OMIM    138960
 3D Structure    ModBase 3D Structure for P04141
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    >96% by SDS-PAGE and HPLC analyses.
 Form/Format    Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.4.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Section Bar
 Molecular Weight Information    Approximately 14.4 kDa, a single non-glycosylated polypeptide chain containing 127 amino acids.
 Biological Activity    Fully biologically active when compared to standard. The ED50 as calculated by the dose-dependant stimulation of the proliferation of human TF-1 cells is less then 0.1 ng/ml, corresponding to a Specific Activity of 1 x 107 IU/mg.
 Endotoxin Level    Less than 1EU/mg of rHuGM-CSF as determined by LAL method.
 Reconstitution    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.
Section Bar
 Preparation and Storage    This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of CSF2 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for CSF2 protein

   GM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine or immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages and eosinophils. GMCSF has also been reported to have a functional role on non-hematopoietic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. GM-CSF is species specific and human GM-CSF has no biological effects on mouse cells.
NCBI/Uniprot data below describe general gene information for CSF2. It may not necessarily be applicable to this product.
 NCBI GI #    27437030
 NCBI GeneID    1437
 NCBI Accession #    NP_000749.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000758.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P04141 [Other Products]
 UniProt Secondary Accession #    Q14CE8; Q2VPI8; Q8NFI6 [Other Products]
 UniProt Related Accession #    P04141 [Other Products]
 Molecular Weight    16,295 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    granulocyte-macrophage colony-stimulating factor
 NCBI Official Synonym Full Names    colony stimulating factor 2 (granulocyte-macrophage)
 NCBI Official Symbol    CSF2 [Similar Products]
 NCBI Official Synonym Symbols   
GMCSF
[Similar Products]
 NCBI Protein Information    granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim
 UniProt Protein Name    Granulocyte-macrophage colony-stimulating factor
 UniProt Synonym Protein Names   
Colony-stimulating factor; CSF; Molgramostin; Sargramostim
 Protein Family    Granulocyte-macrophage colony-stimulating factor
 UniProt Gene Name    CSF2 [Similar Products]
 UniProt Synonym Gene Names    GMCSF; GM-CSF; CSF [Similar Products]
 UniProt Entry Name    CSF2_HUMAN
Section Bar
 NCBI Summary for CSF2    The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for CSF2    GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication
Table BarTOPTable Bar
 Research Articles on CSF2    1. CBL linker and RING finger mutants lead to enhanced GM-CSF signaling due to elevated kinase expression, which can be blocked using small molecule inhibitors targeting specific downstream pathways.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with CSF2 proteinPathways associated with CSF2 protein
 Reference Product  PubMed Publications
 IL4 protein  >16 publications with CSF2 and IL4
 IL3 protein  >13 publications with CSF2 and IL3
 IL5 protein  >9 publications with CSF2 and IL5
 CSF2RB protein  >8 publications with CSF2 and CSF2RB
 CSF2RA protein  >5 publications with CSF2 and CSF2RA
 FOS protein  >2 publications with CSF2 and FOS
 STAT3 protein  >1 publications with CSF2 and STAT3
 JAK2 protein  >1 publications with CSF2 and JAK2
 SDC2 protein  >1 publications with CSF2 and SDC2
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
Diseases associated with CSF2 proteinOrgans/Tissues associated with CSF2 protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >31 publications with CSF2 and Inflammation
 Necrosis Antibodies  >23 publications with CSF2 and Necrosis
 Neoplasms Antibodies  >20 publications with CSF2 and Neoplasms
 Lung Diseases Antibodies  >8 publications with CSF2 and Lung Diseases
 Breast Neoplasms Antibodies  >5 publications with CSF2 and Breast Neoplasms
 Carcinoma Antibodies  >3 publications with CSF2 and Carcinoma
 Leukemia, Myeloid, Acute Antibodies  >3 publications with CSF2 and Leukemia, Myeloid, Acute
 Liver Diseases Antibodies  >3 publications with CSF2 and Liver Diseases
 Lung Neoplasms Antibodies  >3 publications with CSF2 and Lung Neoplasms
 Arthritis, Rheumatoid Antibodies  >2 publications with CSF2 and Arthritis, Rheumatoid
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with CSF2 and Blood
 Bone Antibodies  >12 publications with CSF2 and Bone
 Lung Antibodies  >9 publications with CSF2 and Lung
 Intestine Antibodies  >1 publications with CSF2 and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions