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IL13 protein :: Interleukin-13 Protein

Scan QR to view Datasheet Catalog #    MBS546027 IL13 protein
Unit / Price
0.002 mg  /  $165 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,165 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-13 (IL13), Protein

★Popular Item★
 Also Known As   

Recombinant Human Interleukin-13 (rHu IL-13)

 Product Synonym Names    Interleukin-13; human IL-13; Human Interleukin-13
 Product Gene Name   

IL13 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    SPGPVPPSTA LRELIEELVN ITQNQKAPLC NGSMVWSINL TAGMYCAALE SLINVSGCSA IEKTQRMLSG FCPHKVSAGQ FSSLHVRDTK IEVAQFVKDL LLHLKKLFRE GRFN
 Chromosome Location    Chromosome: 5; NC_000005.9 (131993865..131996801). Location: 5q31
 OMIM    147683
 3D Structure    ModBase 3D Structure for P35225
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 Host    E Coli
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 Purity/Purification    >96% by SDS-PAGE and HPLC analyses.
 Form/Format    Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.
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 Molecular Weight Information    Approximately 12.5 kDa, a single non-glycosulated polypeptide chain containing 114 amino acids.
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 1.0 ng/ml, corresponding to a specific activity of > 1 x 106 units/mg.
 Endotoxin Level    Less than 1EU/mg of rHuIL-13 as determined by LAL method.
 Reconstitution    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.
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 Preparation and Storage    This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles
 Other Notes    Small volumes of IL13 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL13 protein

   IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive.
NCBI/Uniprot data below describe general gene information for IL13. It may not necessarily be applicable to this product.
 NCBI GI #    26787978
 NCBI GeneID    3596
 NCBI Accession #    NP_002179.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002188.2 [Other Products]
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 UniProt Primary Accession #    P35225 [Other Products]
 UniProt Secondary Accession #    O43644; Q4VB52; Q9UDC7 [Other Products]
 UniProt Related Accession #    P35225 [Other Products]
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 NCBI Official Full Name    interleukin-13
 NCBI Official Synonym Full Names    interleukin 13
 NCBI Official Symbol    IL13 [Similar Products]
 NCBI Official Synonym Symbols   
P600; IL-13
[Similar Products]
 NCBI Protein Information    interleukin-13
 UniProt Protein Name    Interleukin-13
 Protein Family    Interleukin
 UniProt Gene Name    IL13 [Similar Products]
 UniProt Synonym Gene Names    NC30; IL-13 [Similar Products]
 UniProt Entry Name    IL13_HUMAN
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 NCBI Summary for IL13    This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL13    IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function: protein binding; interleukin-13 receptor binding; cytokine activity

Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; microglial cell activation; regulation of proton transport; response to lipopolysaccharide; signal transduction; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; response to ethanol; cell-cell signaling; positive regulation of protein secretion; positive regulation of B cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of NAD(P)H oxidase activity; cell motility; inflammatory response; positive regulation of macrophage activation

Disease: Asthma, Susceptibility To; Allergic Rhinitis
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 Research Articles on IL13    1. The association of asthma with variation near RAD50/IL13, first discovered in individuals of European ancestry, replicates in individuals of African ancestry.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL13 proteinPathways associated with IL13 protein
 Reference Product  PubMed Publications
 STAT6 protein  >385 publications with IL13 and STAT6
 IL13RA1 protein  >287 publications with IL13 and IL13RA1
 IL5 protein  >92 publications with IL13 and IL5
 IL18 protein  >85 publications with IL13 and IL18
 GATA3 protein  >84 publications with IL13 and GATA3
 IL4R protein  >56 publications with IL13 and IL4R
 TSLP protein  >28 publications with IL13 and TSLP
 IL13RA2 protein  >12 publications with IL13 and IL13RA2
 VCAM1 protein  >5 publications with IL13 and VCAM1
 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 IL12 Signaling Mediated By STAT4 Pathway antibodies  IL12 Signaling Mediated By STAT4 Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
Diseases associated with IL13 proteinOrgans/Tissues associated with IL13 protein
 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >1252 publications with IL13 and Hypersensitivity
 Inflammation Antibodies  >1185 publications with IL13 and Inflammation
 Asthma Antibodies  >1169 publications with IL13 and Asthma
 Hypersensitivity, Immediate Antibodies  >1087 publications with IL13 and Hypersensitivity, Immediate
 Lung Diseases Antibodies  >1066 publications with IL13 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >904 publications with IL13 and Respiratory Hypersensitivity
 Necrosis Antibodies  >574 publications with IL13 and Necrosis
 Fibrosis Antibodies  >296 publications with IL13 and Fibrosis
 Bronchial Hyperreactivity Antibodies  >213 publications with IL13 and Bronchial Hyperreactivity
 Nervous System Diseases Antibodies  >178 publications with IL13 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >162 publications with IL13 and Brain
 Bone Marrow Antibodies  >129 publications with IL13 and Bone Marrow
 Mixed Antibodies  >66 publications with IL13 and Mixed
 Testis Antibodies  >6 publications with IL13 and Testis
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