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IL31 protein :: Interleukin-31 Protein

Scan QR to view Datasheet Catalog #    MBS546163 IL31 protein
Unit / Price
0.002 mg  /  $165 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,165 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-31 (IL31), Protein

★Popular Item★
 Also Known As   

RecombinantHuman Interleukin-31 (rHu IL-31)

 Product Synonym Names    Interleukin-31; human IL-31; Human Interleukin-31
 Product Gene Name   

IL31 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (122656577..122658746, complement). Location: 12q24.31
 OMIM    609509
 3D Structure    ModBase 3D Structure for Q6EBC2
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 Host    E Coli
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 Purity/Purification    >97% by SDS-PAGE and HPLC analyses.
 Form/Format    Lyophilized from a 0.2mm filtered concentrated solution in PBS.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
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 Molecular Weight Information    Approximately 15.6 kDa, a single non-glycosylated polypeptide chain containing 135 amino acids
 Biological Activity    Fully biologically active when compared to standard.Measured by its ability to induce STAT3 activation in U-87 MG human glioblastoma/astrocytoma cells. 5 ng/mL of rhIL31 can effectively induce STAT3 activation.
 Endotoxin Level    Less than 1EU/mg of rHuIL-31 as determined by LAL method.
 Reconstitution    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.
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 Preparation and Storage    This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of IL31 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL31 protein

   Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL- 31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.
NCBI/Uniprot data below describe general gene information for IL31. It may not necessarily be applicable to this product.
 NCBI GI #    62122911
 NCBI GeneID    386653
 NCBI Accession #    NP_001014358.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001014336.1 [Other Products]
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 UniProt Primary Accession #    Q6EBC2 [Other Products]
 UniProt Secondary Accession #    A2RUQ1 [Other Products]
 UniProt Related Accession #    Q6EBC2 [Other Products]
 Molecular Weight    18,205 Da [Similar Products]
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 NCBI Official Full Name    interleukin-31
 NCBI Official Synonym Full Names    interleukin 31
 NCBI Official Symbol    IL31 [Similar Products]
 NCBI Official Synonym Symbols   
IL-31
[Similar Products]
 NCBI Protein Information    interleukin-31
 UniProt Protein Name    Interleukin-31
 Protein Family    Interleukin
 UniProt Gene Name    IL31 [Similar Products]
 UniProt Synonym Gene Names    IL-31 [Similar Products]
 UniProt Entry Name    IL31_HUMAN
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 NCBI Summary for IL31    IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for IL31    IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: immune system process
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 Research Articles on IL31    1. IL-31 induces pro-inflammatory effects in activated human macrophages via STAT-1 and 5 phosphorylation. Interleukin-31-induced ERK 1/2 activation contributes to the underlying mechanism of Th1 cytokine IL-12 suppression in macrophages.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL31 proteinDiseases associated with IL31 protein
 Reference Product  PubMed Publications
 IL31RA protein  >12 publications with IL31 and IL31RA
 OSMR protein  >8 publications with IL31 and OSMR
 IL6ST protein  >1 publications with IL31 and IL6ST
 Disease Name  Pubmed Publications
 Dermatitis, Atopic Antibodies  >37 publications with IL31 and Dermatitis, Atopic
 Inflammation Antibodies  >19 publications with IL31 and Inflammation
 Brain Diseases Antibodies  >3 publications with IL31 and Brain Diseases
 Autoimmune Diseases Antibodies  >2 publications with IL31 and Autoimmune Diseases
 Necrosis Antibodies  >2 publications with IL31 and Necrosis
 Movement Disorders Antibodies  >1 publications with IL31 and Movement Disorders
 Hypersensitivity, Delayed Antibodies  >1 publications with IL31 and Hypersensitivity, Delayed
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