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LBP protein

Scan QR to view Datasheet Catalog #    MBS584635 LBP protein
Unit / Price
0.1 mg  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LBP, Protein

★Popular Item★
 Also Known As   

LBP, Human, Peptide

 Product Gene Name   

LBP protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    LBP-peptid e is H2N-RVQGRW KVRKSFFK-C ONH2
 OMIM    151990
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 Purity/Purification    >95%
 Form/Format    Lyophilized, purified LBP-peptide from human LBP protein in PBS. The exact peptide amount is indicated on the label. Reconstitute the vial by pipetting sterile, endotoxin free phosphate buffered saline.
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 Species    Human
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 Preparation and Storage    Lyophilized product should be stored at 4 degree C. The stock solution should be stored in aliquots at -70 degree C in polypropylene tubes. LBP-peptide stock solution should never be thawed more than once. Repeated freeze and thaw cycles will cause loss of LBP-peptide activity. Under recommended storage conditions, product is stable for more than one year.
 Other Notes    Small volumes of LBP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LBP protein

   Product Description: LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into lipoproteins which neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria. The LBP-peptide, amino acids 86-99, binds lipid A and neutralizes LPS in vivo and in vitro.
 Application Notes for LBP protein    Application Use: For neutralization of biological activity dilutions have to be made according to the amounts protein to be inactivated. Further dilutions should be made by using protein stabilized phosphate buffered saline, pH 7. (Never use fresh serum/plasma). Be aware: endotoxin will bind LBP-peptide.
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NCBI/Uniprot data below describe general gene information for LBP. It may not necessarily be applicable to this product.
 NCBI GI #    116242615
 NCBI GeneID    3929
 NCBI Accession #    P18428.3 [Other Products]
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 UniProt Secondary Accession #    O43438; Q92672; Q9H403; Q9UD66; B2R938 [Other Products]
 UniProt Related Accession #    P18428 [Other Products]
 Molecular Weight    53,384 Da
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 NCBI Official Full Name    Lipopolysaccharide-binding protein
 NCBI Official Synonym Full Names    lipopolysaccharide binding protein
 NCBI Official Symbol    LBP [Similar Products]
 NCBI Official Synonym Symbols   
BPIFD2
[Similar Products]
 NCBI Protein Information    lipopolysaccharide-binding protein; LPS-binding protein; BPI fold containing family D, member 2
 UniProt Protein Name    Lipopolysaccharide-binding protein
 Protein Family    Lipopolysaccharide-binding protein
 UniProt Gene Name    LBP [Similar Products]
 UniProt Synonym Gene Names    LBP [Similar Products]
 UniProt Entry Name    LBP_HUMAN
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 NCBI Summary for LBP    The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
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 UniProt Comments for LBP    LBP: Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex seems to interact with the CD14 receptor. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: extracellular space; cell surface; extracellular region

Molecular Function: protein binding; lipopolysaccharide binding; receptor binding

Biological Process: positive regulation of tumor necrosis factor biosynthetic process; detection of molecule of bacterial origin; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; defense response to Gram-negative bacterium; positive regulation of tumor necrosis factor production; leukocyte chemotaxis during inflammatory response; positive regulation of chemokine production; positive regulation of interleukin-8 production; lipopolysaccharide transport; defense response to Gram-positive bacterium; macrophage activation during immune response; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; acute-phase response; cellular defense response; innate immune response; opsonization; toll-like receptor 4 signaling pathway; positive regulation of macrophage activation
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Product References and Citations for LBP protein

   Bucki, R et al; Extracellular Gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. J of Immunol. 2008, 181: 4936
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 Research Articles on LBP    1. report pre-ART IL-6 and LBP levels as well as IL-6, LBP and I-FABP levels during IRIS-event as potential biomarkers in TB-IRIS
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LBP proteinPathways associated with LBP protein
 Reference Product  PubMed Publications
 CD14 protein  >423 publications with LBP and CD14
 JUN protein  >390 publications with LBP and JUN
 TLR4 protein  >114 publications with LBP and TLR4
 LY96 protein  >18 publications with LBP and LY96
 CAMP protein  >9 publications with LBP and CAMP
 FOS protein  >4 publications with LBP and FOS
 STAT3 protein  >4 publications with LBP and STAT3
 Products by Pathway  Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Regulation Of Toll-like Receptor Signaling Pathway antibodies  Regulation Of Toll-like Receptor Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Toll Like Receptor 4 (TLR4) Cascade Pathway antibodies  Toll Like Receptor 4 (TLR4) Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
Diseases associated with LBP protein
 Disease Name  Pubmed Publications
 Pain Antibodies  >2953 publications with LBP and Pain
 Nervous System Diseases Antibodies  >2394 publications with LBP and Nervous System Diseases
 Inflammation Antibodies  >331 publications with LBP and Inflammation
 Necrosis Antibodies  >241 publications with LBP and Necrosis
 Sepsis Antibodies  >171 publications with LBP and Sepsis
 Cardiovascular Diseases Antibodies  >89 publications with LBP and Cardiovascular Diseases
 Liver Diseases Antibodies  >76 publications with LBP and Liver Diseases
 Obesity Antibodies  >67 publications with LBP and Obesity
 Carcinoma Antibodies  >48 publications with LBP and Carcinoma
 Brain Diseases Antibodies  >47 publications with LBP and Brain Diseases
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