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PNLIP protein :: Lipase Protein

Scan QR to view Datasheet Catalog #    MBS173153 PNLIP protein
Unit / Price
100 Units  /  $260 +1 FREE 8GB USB
500 Units  /  $620 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lipase (PNLIP), Protein

★Popular Item★
 Also Known As   

Lipase, Human Pancreas

 Product Synonym Names    Pancreatic Triacylglycerol Lipase; PL; PTL; Pancreatic Lipase; Lipase, Human Pancreas - High Purity - Lyophilized
 Product Gene Name   

PNLIP protein

[Similar Products]
 Product Synonym Gene Name    RP11-33D13.1; PL; PNLIPD; PTL [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS173153 COA    COA PDF
 OMIM    601980
 3D Structure    ModBase 3D Structure for P16233
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 Purity/Purification    Purified
 Form/Format    Lyophilized from tris chloride, pH 8.0, with sodium chloride, benzamidine and calcium chloride
Appearance: Tan powder
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 Source    Human Pancreas
 EC Number    3.1.1.3
 CAS Number    9001-62-1
 Solubility    Clear, colorless (1 mg/mL saline)
 Activity    100 units/vial (Dimension® Clinical Chemistry System)
 Unit Definition    One unit will catalyze the hydrolysis of one micromole per minute of 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6’-methylresorufin) ester in the presence of co-lipase, bile salt, and calcium chloride at 37 degree C.
 Protein    0.03 mg protein/vial (Coomassie)
 Specific Activity    3,000 units/mg protein (Coomassie)
 Amylase    <0.01%
 Protease    <0.01%
 Ammonia    <0.01 micromole/vial
 Declaration of Helsinki    All Donors provided signed Informed Consent in compliance with Declaration of Helsinki and filed with the appropriate agency/organization in the US.
 Advice    Reconstitute with tris buffered saline containing 1% BSA and 1 mM calcium chloride.
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 Preparation and Storage    Aliquot and freeze at -20 degree C after reconstitution.
Handling: Handle as a potentially hazardous substance.
Storage Note: Protect from moisture
Shipping Note: Cold pack
 Other Notes    Small volumes of PNLIP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PNLIP protein

   MyBioSource is the leading supplier of Human Pancreatic Lipase, for research and clinical diagnostic manufacturers.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human Pancreatic lipase enzyme is a water-soluble enzyme that catalyzes the hydrolysis of ester bonds in water-insoluble, lipid substrates. Most lipases act at a specific position on the glycerol backbone of a lipid substrate (A1, A2 or A3).

Human pancreatic lipase clinical significance: Investigations of pancreatic disorders, pancreatitis, acute and chronic renal disease.
 Product Categories/Family for PNLIP protein    Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Lipase
NCBI/Uniprot data below describe general gene information for PNLIP. It may not necessarily be applicable to this product.
 NCBI GI #    344242
 NCBI GeneID    8513
 NCBI Accession #    CAA00125.1 [Other Products]
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 UniProt Primary Accession #    P16233 [Other Products]
 UniProt Secondary Accession #    Q2M1P6; Q5VXI7; Q5VXI8; Q658L8; B7Z723; F5H1P4 [Other Products]
 UniProt Related Accession #    P07098 [Other Products]
 Molecular Weight    48 kDa
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 NCBI Official Full Name    lipase
 NCBI Official Synonym Full Names    lipase, gastric
 NCBI Official Symbol    LIPF [Similar Products]
 NCBI Official Synonym Symbols   
GL; HGL; HLAL
[Similar Products]
 NCBI Protein Information    gastric triacylglycerol lipase; gastric lipase
 UniProt Protein Name    Gastric triacylglycerol lipase
 Protein Family    Lipase
 UniProt Gene Name    LIPF [Similar Products]
 UniProt Synonym Gene Names    GL; Gastric lipase [Similar Products]
 UniProt Entry Name    LIPG_HUMAN
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 NCBI Summary for PNLIP    This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
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 UniProt Comments for PNLIP    PNLIP: a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]

Protein type: EC 3.1.1.3; Secreted, signal peptide; Secreted; Lipid Metabolism - glycerolipid; Hydrolase

Chromosomal Location of Human Ortholog: 10q26.1

Cellular Component: extracellular region

Molecular Function: triacylglycerol lipase activity; metal ion binding

Biological Process: phototransduction, visible light; cholesterol absorption; retinoid metabolic process; lipid digestion; lipid catabolic process

Disease: Pancreatic Lipase Deficiency
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 Research Articles on PNLIP    1. Recombinant human gastric lipase (hGL) was transiently expressed in Nicotiana benthamiana leaves using the CPMV-HT expression system.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PNLIP proteinPathways associated with PNLIP protein
 Reference Product  PubMed Publications
 LIPC protein  >1 publications with PNLIP and LIPC
 Products by Pathway  Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Triacylglyceride Synthesis Pathway antibodies  Triacylglyceride Synthesis Pathway Diagram
Diseases associated with PNLIP proteinOrgans/Tissues associated with PNLIP protein
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >2 publications with PNLIP and Fibrosis
 Obesity Antibodies  >2 publications with PNLIP and Obesity
 Cardiovascular Diseases Antibodies  >1 publications with PNLIP and Cardiovascular Diseases
 Inflammation Antibodies  >1 publications with PNLIP and Inflammation
 Weight Loss Antibodies  >1 publications with PNLIP and Weight Loss
 Cholestasis Antibodies  >1 publications with PNLIP and Cholestasis
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with PNLIP and Lung
 Skin Antibodies  >2 publications with PNLIP and Skin
 Testis Antibodies  >1 publications with PNLIP and Testis
 Connective Tissue Antibodies  >1 publications with PNLIP and Connective Tissue
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