NP_001035199.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,674 Da
NCBI Official Full Name
nuclear respiratory factor 1 isoform 1
NCBI Official Synonym Full Names
nuclear respiratory factor 1
NCBI Official Synonym Symbols
NCBI Protein Information
nuclear respiratory factor 1
UniProt Protein Name
Nuclear respiratory factor 1
UniProt Synonym Protein Names
Alpha palindromic-binding protein; Alpha-pal
UniProt Synonym Gene Names
NCBI Summary for Nrf1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
UniProt Comments for Nrf1
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Research Articles on Nrf1
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Products associated with Nrf1 protein
Pathways associated with Nrf1 protein
Diseases associated with Nrf1 protein
Organs/Tissues associated with Nrf1 protein
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