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SPP1 protein :: Osteopontin Protein

Scan QR to view Datasheet Catalog #    MBS173394 SPP1 protein
Unit / Price
0.025 mg  /  $380 +1 FREE 8GB USB
0.1 mg  /  $800 +1 FREE 8GB USB
1 mg  /  $2,220 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Osteopontin (SPP1), Protein

★Popular Item★
 Also Known As   

Osteopontin, Human Breast Milk

 Product Synonym Names    OPN, Bone sialoprotein, BSP-1
 Product Gene Name   

SPP1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    166490
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 Host    Human Milk
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 Purity/Purification    >= 95% (SDS-PAGE, multiple bands 40-60 kDa, representing variants in glycosylation)
 Form/Format    Solution in 10mM Sodium Phosphate, 150mM sodium chloride, and 0.1% sodium azide, pH7.2.
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 Source    Human Breast Milk
 Appearance    Frozen liquid
 Protein    1.7mg/ml (E0.1%280nm=0.67)
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 Preparation and Storage    At -20 degree C
Avoid freeze/thaws
Shipping: Ships with Dry Ice
 Other Notes    Small volumes of SPP1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SPP1 protein

   Custom preparations, technical support, bulk quantities and aliquoting available.

Research has been found that OPN interacts with multiple cell surface receptors which are ubiquitously expressed making it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation, ischemia and immune responses. Therefore studies have shown that manipulation of plasma OPN levels may be useful in the treatment of autoimmune diseases, cancer metastasis, osteoporosis and some forms of stress.

Osteopontin has been implicated in autoimmune diseases such as rheumatoid arthritis, autoimmune hepatitis, and multiple sclerosis. According to current research Osteopontin has also been associated with allergic inflammation and asthma, plays a number of roles in the diseases of skeletal muscles and has been found to be overexpressed in a variety of cancers such as lung cancer, breast cancer, colorectal cancer, stomach cancer and ovarian cancer.
 Product Categories/Family for SPP1 protein    Proteins; Antigens; Standards/controls; Native Proteins; Osteopontin (opn)
 Applications Tested/Suitable for SPP1 protein   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for SPP1. It may not necessarily be applicable to this product.
 NCBI GI #    189405
 NCBI GeneID    6696
 NCBI Accession #    AAA59974.1 [Other Products]
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 UniProt Secondary Accession #    Q15681; Q15682; Q15683; Q4W597; Q567T5; Q8NBK2; Q96IZ1; B2RDA1 [Other Products]
 UniProt Related Accession #    P10451 [Other Products]
 Molecular Weight    40,000 - 60,000 (glycosylation) [Similar Products]
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 NCBI Official Full Name    osteopontin
 NCBI Official Synonym Full Names    secreted phosphoprotein 1
 NCBI Official Symbol    SPP1 [Similar Products]
 NCBI Official Synonym Symbols   
OPN; BNSP; BSPI; ETA-1
[Similar Products]
 NCBI Protein Information    osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
 UniProt Protein Name    Osteopontin
 UniProt Synonym Protein Names   
Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin
 Protein Family    Osteopontin
 UniProt Gene Name    SPP1 [Similar Products]
 UniProt Synonym Gene Names    BNSP; OPN; SPP-1 [Similar Products]
 UniProt Entry Name    OSTP_HUMAN
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 NCBI Summary for SPP1    The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for SPP1    osteopontin: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Belongs to the osteopontin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: extracellular space; cell projection; perinuclear region of cytoplasm; apical part of cell; extracellular region

Molecular Function: protein binding; extracellular matrix binding; cytokine activity

Biological Process: osteoblast differentiation; extracellular matrix disassembly; neutrophil chemotaxis; extracellular matrix organization and biogenesis; response to vitamin D; response to steroid hormone stimulus; biomineral formation; negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of bone resorption; decidualization; inflammatory response; cell adhesion; embryo implantation
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 Research Articles on SPP1    1. The trend towards elevated urinary OPN in diabetic subjects results from enhanced glomerulus dysfunction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SPP1 proteinPathways associated with SPP1 protein
 Reference Product  PubMed Publications
 CD44 protein  >126 publications with SPP1 and CD44
 RUNX2 protein  >122 publications with SPP1 and RUNX2
 BMP2 protein  >73 publications with SPP1 and BMP2
 PTH protein  >40 publications with SPP1 and PTH
 FN1 protein  >11 publications with SPP1 and FN1
 ITGA5 protein  >4 publications with SPP1 and ITGA5
 ITGB3 protein  >3 publications with SPP1 and ITGB3
 ITGB1 protein  >2 publications with SPP1 and ITGB1
 ITGAV protein  >2 publications with SPP1 and ITGAV
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with SPP1 proteinOrgans/Tissues associated with SPP1 protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >261 publications with SPP1 and Cardiovascular Diseases
 Inflammation Antibodies  >236 publications with SPP1 and Inflammation
 Kidney Diseases Antibodies  >227 publications with SPP1 and Kidney Diseases
 Fibrosis Antibodies  >150 publications with SPP1 and Fibrosis
 Neoplasm Metastasis Antibodies  >134 publications with SPP1 and Neoplasm Metastasis
 Necrosis Antibodies  >124 publications with SPP1 and Necrosis
 Calcinosis Antibodies  >111 publications with SPP1 and Calcinosis
 Adenocarcinoma Antibodies  >102 publications with SPP1 and Adenocarcinoma
 Heart Diseases Antibodies  >101 publications with SPP1 and Heart Diseases
 Liver Diseases Antibodies  >84 publications with SPP1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1066 publications with SPP1 and Bone
 Blood Antibodies  >526 publications with SPP1 and Blood
 Kidney Antibodies  >363 publications with SPP1 and Kidney
 Vascular Antibodies  >332 publications with SPP1 and Vascular
 Connective Tissue Antibodies  >327 publications with SPP1 and Connective Tissue
 Muscle Antibodies  >278 publications with SPP1 and Muscle
 Bone Marrow Antibodies  >187 publications with SPP1 and Bone Marrow
 Mouth Antibodies  >176 publications with SPP1 and Mouth
 Heart Antibodies  >128 publications with SPP1 and Heart
 Liver Antibodies  >123 publications with SPP1 and Liver
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