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SERPINE1 protein :: PAI-1 (Biotin labeled stable mutant) Protein

Scan QR to view Datasheet Catalog #    MBS135847 SERPINE1 protein
Unit / Price
0.5 mg  /  $730 +1 FREE 8GB USB
1 mg  /  $1,310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAI-1 (Biotin labeled stable mutant) (SERPINE1), Protein

 Also Known As   

Rat PAI-1 (Biotin labeled stable mutant)

 Product Gene Name   

SERPINE1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_005111.3 (24653385..24663763). Location: 12q11-q12
 3D Structure    ModBase 3D Structure for P20961
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 Host    E. coli
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 Purity/Purification    >95% by SDS-PAGE analysis
 Form/Format    Frozen liquid
 Concentration    2.5 mg/ml (lot specific)
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 Buffer    0.05M Sodium Acetate; 0.4M NaCl; 1mM EDTA; pH 5.0
 Extinction Coefficient    1
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 3 years from delivery
 Other Notes    Small volumes of SERPINE1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SERPINE1 protein

   This recombinant rat PAI-1 has a single conservative mutation (Isoleucine 91 to Leucine) for increased half-life and is biotin labeled on lysine residues.
 Product Categories/Family for SERPINE1 protein    Plasminogen Activator Inhibitor 1 (PAI-1); Rat PAI-1
NCBI/Uniprot data below describe general gene information for SERPINE1. It may not necessarily be applicable to this product.
 NCBI GI #    6981332
 NCBI GeneID    24617
 NCBI Accession #    NP_036752.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012620.1 [Other Products]
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 UniProt Primary Accession #    P20961 [Other Products]
 UniProt Related Accession #    P20961 [Other Products]
 Molecular Weight    43,000
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 NCBI Official Full Name    plasminogen activator inhibitor 1
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 NCBI Official Symbol    Serpine1 [Similar Products]
 NCBI Official Synonym Symbols   
Pai1; PAI1A; Planh; Pai1aa; RATPAI1A
[Similar Products]
 NCBI Protein Information    plasminogen activator inhibitor 1; PAI; PAI-1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, member 1; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 UniProt Protein Name    Plasminogen activator inhibitor 1
 UniProt Synonym Protein Names   
Endothelial plasminogen activator inhibitor; Serpin E1
 Protein Family    Plasminogen activator inhibitor
 UniProt Gene Name    Serpine1 [Similar Products]
 UniProt Synonym Gene Names    Pai1; Planh1; PAI; PAI-1 [Similar Products]
 UniProt Entry Name    PAI1_RAT
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 NCBI Summary for SERPINE1    mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator; may promote neuronal survival [RGD, Feb 2006]
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 UniProt Comments for SERPINE1    SERPINE1: a secreted protein that acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protease binding; receptor binding

Biological Process: positive regulation of blood coagulation; wound healing; positive regulation of coagulation; response to lipopolysaccharide; negative regulation of smooth muscle cell migration; decidualization; glucose homeostasis; defense response to Gram-negative bacterium; mast cell activation; positive regulation of receptor-mediated endocytosis; positive regulation of interleukin-8 production; positive regulation of fibroblast proliferation; negative regulation of fibrinolysis; tissue regeneration; angiogenesis; regulation of receptor activity; chronological cell aging; negative regulation of cell migration; negative regulation of cell adhesion mediated by integrin; female gonad development; positive regulation of keratinocyte migration; negative regulation of proteolysis; regulation of angiogenesis; regulation of cell proliferation; response to starvation; response to reactive oxygen species; positive regulation of angiogenesis; response to hyperoxia; cellular response to insulin stimulus; response to estrogen stimulus; response to cytokine stimulus; positive regulation of inflammatory response
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 Research Articles on SERPINE1    1. adhesion scores, PAI-1 activity in peritoneal lavage fluid, and PAI-1 mRNA levels in peritoneal mesothelium were significantly greater in the open surgery group than the control and laparoscopic surgery groups
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SERPINE1 proteinDiseases associated with SERPINE1 protein
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies  BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Brain Derived Neurotrophic Factor Pathway antibodies  Brain Derived Neurotrophic Factor Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2981 publications with SERPINE1 and Cardiovascular Diseases
 Neoplasms Antibodies  >1328 publications with SERPINE1 and Neoplasms
 Thrombosis Antibodies  >1295 publications with SERPINE1 and Thrombosis
 Inflammation Antibodies  >1140 publications with SERPINE1 and Inflammation
 Heart Diseases Antibodies  >977 publications with SERPINE1 and Heart Diseases
 Necrosis Antibodies  >775 publications with SERPINE1 and Necrosis
 Atherosclerosis Antibodies  >721 publications with SERPINE1 and Atherosclerosis
 Hypertension Antibodies  >651 publications with SERPINE1 and Hypertension
 Fibrosis Antibodies  >603 publications with SERPINE1 and Fibrosis
 Myocardial Infarction Antibodies  >485 publications with SERPINE1 and Myocardial Infarction
Organs/Tissues associated with SERPINE1 protein
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >792 publications with SERPINE1 and Heart
 Liver Antibodies  >539 publications with SERPINE1 and Liver
 Connective Tissue Antibodies  >539 publications with SERPINE1 and Connective Tissue
 Lung Antibodies  >511 publications with SERPINE1 and Lung
 Brain Antibodies  >356 publications with SERPINE1 and Brain
 Placenta Antibodies  >120 publications with SERPINE1 and Placenta
 Spleen Antibodies  >22 publications with SERPINE1 and Spleen
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