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PGHS-1 protein

Scan QR to view Datasheet Catalog #    MBS483007 PGHS-1 protein
Unit / Price
0.01 mg  /  $195 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PGHS-1, Protein

★Popular Item★
 Also Known As   

PGHS-1 Standard, Native Ovine

 Product Synonym Names    Native Ovine Prostaglandin H Synthase-1 Standard
 Product Gene Name   

PGHS-1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176805
 3D Structure    ModBase 3D Structure for P23219
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 Host    Ovine seminal vesicles
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 Purity/Purification    Greater than 95% by electrophoresis
 Concentration    0.1 mg/mL. (lot specific)
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 Contents    10 mug of protein in 100 muL
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 Preparation and Storage    Stable for several months at At -20 degree C, and indefinitely at At -70 degree C.
 Other Notes    Small volumes of PGHS-1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PGHS-1. It may not necessarily be applicable to this product.
 NCBI GI #    18104969
 NCBI GeneID    5742
 NCBI Accession #    NP_542158.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_080591.2 [Other Products]
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 UniProt Primary Accession #    P23219 [Other Products]
 UniProt Secondary Accession #    Q15122; Q3HY28; Q3HY29; Q5T7T6; Q5T7T7; Q5T7T8; A8K1V7; B4DHQ2; B4E2S5 [Other Products]
 UniProt Related Accession #    P23219 [Other Products]
 Molecular Weight    72,010 Da
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 NCBI Official Full Name    prostaglandin G/H synthase 1 isoform 2
 NCBI Official Synonym Full Names    prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
 NCBI Official Symbol    PTGS1 [Similar Products]
 NCBI Official Synonym Symbols   
COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
[Similar Products]
 NCBI Protein Information    prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1
 UniProt Protein Name    Prostaglandin G/H synthase 1
 UniProt Synonym Protein Names   
Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
 UniProt Gene Name    PTGS1 [Similar Products]
 UniProt Synonym Gene Names    COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1 [Similar Products]
 UniProt Entry Name    PGH1_HUMAN
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 NCBI Summary for PGHS-1    This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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 UniProt Comments for PGHS-1    COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - arachidonic acid; EC 1.14.99.1; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q32-q33.3

Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding

Biological Process: xenobiotic metabolic process; regulation of blood pressure; cyclooxygenase pathway; arachidonic acid metabolic process; lipid metabolic process; response to oxidative stress; inflammatory response; prostaglandin biosynthetic process; regulation of cell proliferation
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 Research Articles on PGHS-1    1. Studied the impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter, and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PGHS-1 proteinPathways associated with PGHS-1 protein
 Reference Product  PubMed Publications
 PLA2G4A protein  >97 publications with PGHS-1 and PLA2G4A
 PTGIS protein  >8 publications with PGHS-1 and PTGIS
 PTGES2 protein  >5 publications with PGHS-1 and PTGES2
 PTGES3 protein  >4 publications with PGHS-1 and PTGES3
 TBXAS1 protein  >3 publications with PGHS-1 and TBXAS1
 ALOX15B protein  >2 publications with PGHS-1 and ALOX15B
 PLA2G5 protein  >1 publications with PGHS-1 and PLA2G5
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 COX Reactions Pathway antibodies  COX Reactions Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with PGHS-1 proteinOrgans/Tissues associated with PGHS-1 protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1013 publications with PGHS-1 and Inflammation
 Cardiovascular Diseases Antibodies  >498 publications with PGHS-1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >414 publications with PGHS-1 and Disease Models, Animal
 Pain Antibodies  >351 publications with PGHS-1 and Pain
 Necrosis Antibodies  >292 publications with PGHS-1 and Necrosis
 Carcinoma Antibodies  >275 publications with PGHS-1 and Carcinoma
 Edema Antibodies  >242 publications with PGHS-1 and Edema
 Heart Diseases Antibodies  >161 publications with PGHS-1 and Heart Diseases
 Hypertension Antibodies  >153 publications with PGHS-1 and Hypertension
 Stomach Ulcer Antibodies  >147 publications with PGHS-1 and Stomach Ulcer
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1304 publications with PGHS-1 and Blood
 Vascular Antibodies  >704 publications with PGHS-1 and Vascular
 Brain Antibodies  >385 publications with PGHS-1 and Brain
 Stomach Antibodies  >364 publications with PGHS-1 and Stomach
 Muscle Antibodies  >356 publications with PGHS-1 and Muscle
 Kidney Antibodies  >300 publications with PGHS-1 and Kidney
 Heart Antibodies  >264 publications with PGHS-1 and Heart
 Intestine Antibodies  >220 publications with PGHS-1 and Intestine
 Lung Antibodies  >218 publications with PGHS-1 and Lung
 Liver Antibodies  >201 publications with PGHS-1 and Liver
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