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PKC-epsilon protein

Scan QR to view Datasheet Catalog #    MBS483015 PKC-epsilon protein
Unit / Price
0.1 mg  /  $200 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PKC-epsilon, Protein

★Popular Item★
 Also Known As   

PKC-epsilon Specific Peptide

 Product Synonym Names    Protein Kinase C Epsilon Synthetic Peptide
 Product Gene Name   

PKC-epsilon protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Distinct region of protein kinase Cepsi lon C-terminal .
Seque nce: NH2-C-N-Q -E-E-F-K-G -F-S-Y-F-G -E-D-COOH
 OMIM    176975
 3D Structure    ModBase 3D Structure for Q02156
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 Contents    100 mug of peptide in 500 uL of ammonium bicarbonate buffer
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 Preparation and Storage    Stable at 4 degree C. For long term storage, aliquot product and freeze at At -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of PKC-epsilon protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for PKC-epsilon protein   

Western Blot (WB)

 Application Notes for PKC-epsilon protein    Will compete with the anti-peptide antibody in Western blotting for confirmation of the PKC specificity of the antibody binding.
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NCBI/Uniprot data below describe general gene information for PKC-epsilon. It may not necessarily be applicable to this product.
 NCBI GI #    4885563
 NCBI GeneID    5581
 NCBI Accession #    NP_005391.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005400.2 [Other Products]
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 UniProt Primary Accession #    Q02156 [Other Products]
 UniProt Secondary Accession #    Q32MQ3; Q53SL4; Q53SM5; Q9UE81; B0LPH7 [Other Products]
 UniProt Related Accession #    Q02156 [Other Products]
 Molecular Weight    83,674 Da
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 NCBI Official Full Name    protein kinase C epsilon type
 NCBI Official Synonym Full Names    protein kinase C, epsilon
 NCBI Official Symbol    PRKCE [Similar Products]
 NCBI Official Synonym Symbols   
PKCE; nPKC-epsilon
[Similar Products]
 NCBI Protein Information    protein kinase C epsilon type
 UniProt Protein Name    Protein kinase C epsilon type
 UniProt Synonym Protein Names   
nPKC-epsilon
 UniProt Gene Name    PRKCE [Similar Products]
 UniProt Synonym Gene Names    PKCE [Similar Products]
 UniProt Entry Name    KPCE_HUMAN
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 NCBI Summary for PKC-epsilon    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PKC-epsilon    PKCE: an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; EC 2.7.11.13; AGC group; PKC family; Eta subfamily

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: Golgi apparatus; cytoskeleton; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: actin monomer binding; calcium-independent protein kinase C activity; protein serine/threonine kinase activity; protein binding; signal transducer activity; enzyme binding; protein kinase C activity; metal ion binding; enzyme activator activity; ethanol binding; ATP binding; receptor activator activity

Biological Process: nerve growth factor receptor signaling pathway; apoptosis; response to morphine; positive regulation of lipid catabolic process; signal transduction; protein amino acid phosphorylation; positive regulation of MAPKKK cascade; lipopolysaccharide-mediated signaling pathway; cell adhesion; regulation of peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; positive regulation of cytokinesis; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; fibroblast growth factor receptor signaling pathway; positive regulation of synaptic transmission, GABAergic; positive regulation of insulin secretion; cell cycle; peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; phospholipase C activation; cell division; release of sequestered calcium ion into cytosol; macrophage activation during immune response; innate immune response; blood coagulation
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 Research Articles on PKC-epsilon    1. Suggest distinct role of PKCepsilon in controlling cell fate and immune response of monocyte subsets.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PKC-epsilon proteinPathways associated with PKC-epsilon protein
 Reference Product  PubMed Publications
 MAPK1 protein  >26 publications with PKC-epsilon and MAPK1
 SRC protein  >22 publications with PKC-epsilon and SRC
 RHOA protein  >6 publications with PKC-epsilon and RHOA
 CDC42 protein  >5 publications with PKC-epsilon and CDC42
 IKBKB protein  >4 publications with PKC-epsilon and IKBKB
 PDPK1 protein  >3 publications with PKC-epsilon and PDPK1
 TJP1 protein  >2 publications with PKC-epsilon and TJP1
 VDAC1 protein  >2 publications with PKC-epsilon and VDAC1
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 DAG And IP3 Signaling Pathway antibodies  DAG And IP3 Signaling Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram
 Downstream Signaling Of Activated FGFR2 Pathway antibodies  Downstream Signaling Of Activated FGFR2 Pathway Diagram
Diseases associated with PKC-epsilon proteinOrgans/Tissues associated with PKC-epsilon protein
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >93 publications with PKC-epsilon and Heart Diseases
 Myocardial Ischemia Antibodies  >71 publications with PKC-epsilon and Myocardial Ischemia
 Hypertrophy Antibodies  >43 publications with PKC-epsilon and Hypertrophy
 Nervous System Diseases Antibodies  >42 publications with PKC-epsilon and Nervous System Diseases
 Necrosis Antibodies  >40 publications with PKC-epsilon and Necrosis
 Cardiomyopathies Antibodies  >37 publications with PKC-epsilon and Cardiomyopathies
 Myocardial Infarction Antibodies  >29 publications with PKC-epsilon and Myocardial Infarction
 Inflammation Antibodies  >26 publications with PKC-epsilon and Inflammation
 Heart Failure Antibodies  >22 publications with PKC-epsilon and Heart Failure
 Pain Antibodies  >18 publications with PKC-epsilon and Pain
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >191 publications with PKC-epsilon and Heart
 Muscle Antibodies  >190 publications with PKC-epsilon and Muscle
 Brain Antibodies  >75 publications with PKC-epsilon and Brain
 Blood Antibodies  >73 publications with PKC-epsilon and Blood
 Liver Antibodies  >38 publications with PKC-epsilon and Liver
 Lung Antibodies  >30 publications with PKC-epsilon and Lung
 Kidney Antibodies  >17 publications with PKC-epsilon and Kidney
 Skin Antibodies  >16 publications with PKC-epsilon and Skin
 Embryonic Tissue Antibodies  >12 publications with PKC-epsilon and Embryonic Tissue
 Bone Antibodies  >11 publications with PKC-epsilon and Bone
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