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PTH protein :: Parathyroid Hormone1-84 Protein

Scan QR to view Datasheet Catalog #    MBS546093 PTH protein
Unit / Price
0.02 mg  /  $165 +1 FREE 8GB USB
0.1 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $810 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Parathyroid Hormone1-84 (PTH), Protein

★Popular Item★
 Also Known As   

Recombinant Human Parathyroid Hormone 1-84 (rHu PTH1-84)

 Product Synonym Names    Parathyroid Hormone1-84; human PTH (1-84); Human Parathyroid Hormone
 Product Gene Name   

PTH protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (13513601..13517567, complement). Location: 11p15.3-p15.1
 OMIM    146200
 3D Structure    ModBase 3D Structure for P01270
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 Purity/Purification    >97% by SDS-PAGE and HPLC analyses.
 Form/Format    Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in 20mM PB, pH 7.0, containing 4% mannitol.
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 Source    E.coli
 Molecular Weight    Approximately 10kDa, a single non-glycosylated polypeptide chain containing 84 amino acids
 Physical Appearance    Sterile Filtered White lyophilized (freeze-dried) powder.
 Biological Activity    Fully biologically active when compared to standard. The activity calculated by UMR106 cell/cAMP method corresponding to a specific activity of 0.9 x 104 Units/mg.
 Endotoxin Level    Less than 1EU/mg of rHuPTH1-84 as determined by LAL method.
 Reconstitution    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20C. Further dilutions should be made in appropriate buffered solutions.
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 Preparation and Storage    This lyophilized preparation is stable at 2-8C, but should be kept at -20C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles
 Other Notes    Small volumes of PTH protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PTH protein

   Polypeptide hormones secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. Its action is opposed by calcitonin.
NCBI/Uniprot data below describe general gene information for PTH. It may not necessarily be applicable to this product.
 NCBI GI #    131547
 NCBI GeneID    5741
 NCBI Accession #    P01270.1 [Other Products]
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 UniProt Primary Accession #    P01270 [Other Products]
 UniProt Secondary Accession #    Q4VB48; Q9UD38 [Other Products]
 UniProt Related Accession #    P01270 [Other Products]
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 NCBI Official Full Name    Parathyroid hormone
 NCBI Official Synonym Full Names    parathyroid hormone
 NCBI Official Symbol    PTH [Similar Products]
 NCBI Official Synonym Symbols   
PTH1
[Similar Products]
 NCBI Protein Information    parathyroid hormone; parathyrin; prepro-PTH; parathormone; parathyroid hormone 1; preproparathyroid hormone
 UniProt Protein Name    Parathyroid hormone
 UniProt Synonym Protein Names   
Parathormone; Parathyrin
 Protein Family    Parathyroid hormone
 UniProt Gene Name    PTH [Similar Products]
 UniProt Synonym Gene Names    PTH [Similar Products]
 UniProt Entry Name    PTHY_HUMAN
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 NCBI Summary for PTH    The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]
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 UniProt Comments for PTH    PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.

Protein type: Secreted; Apoptosis; Hormone; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.3-p15.1

Cellular Component: extracellular space; extracellular region

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding; parathyroid hormone receptor binding; peptide hormone receptor binding; hormone activity

Biological Process: transcription from RNA polymerase II promoter; response to drug; positive regulation of signal transduction; induction of apoptosis by hormones; positive regulation of glycogen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; Rho protein signal transduction; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of glucose import; response to ethanol; cAMP metabolic process; response to vitamin D; response to cadmium ion; cell-cell signaling; regulation of gene expression; response to lead ion; positive regulation of cAMP biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; skeletal development; bone resorption

Disease: Hypoparathyroidism, Familial Isolated
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 Research Articles on PTH    1. These results identify Wasf2 as a novel target of intermittent PTH administration via the Wnt and phosphoinositide-dependent protein kinase signaling pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTH proteinPathways associated with PTH protein
 Reference Product  PubMed Publications
 PTHLH protein  >443 publications with PTH and PTHLH
 VDR protein  >264 publications with PTH and VDR
 FGF23 protein  >212 publications with PTH and FGF23
 CASR protein  >202 publications with PTH and CASR
 PTH1R protein  >193 publications with PTH and PTH1R
 PTH2R protein  >16 publications with PTH and PTH2R
 CALCA protein  >7 publications with PTH and CALCA
 GCG protein  >1 publications with PTH and GCG
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Vitamin D Synthesis Pathway antibodies  Vitamin D Synthesis Pathway Diagram
Diseases associated with PTH proteinOrgans/Tissues associated with PTH protein
 Disease Name  Pubmed Publications
 Hyperparathyroidism Antibodies  >4940 publications with PTH and Hyperparathyroidism
 Bone Diseases Antibodies  >4197 publications with PTH and Bone Diseases
 Kidney Diseases Antibodies  >3162 publications with PTH and Kidney Diseases
 Hyperparathyroidism, Secondary Antibodies  >2707 publications with PTH and Hyperparathyroidism, Secondary
 Bone Diseases, Metabolic Antibodies  >2525 publications with PTH and Bone Diseases, Metabolic
 Hypercalcemia Antibodies  >2335 publications with PTH and Hypercalcemia
 Bone Resorption Antibodies  >2176 publications with PTH and Bone Resorption
 Renal Insufficiency Antibodies  >2025 publications with PTH and Renal Insufficiency
 Osteoporosis Antibodies  >1943 publications with PTH and Osteoporosis
 Kidney Failure, Chronic Antibodies  >1728 publications with PTH and Kidney Failure, Chronic
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >14769 publications with PTH and Parathyroid
 Connective Tissue Antibodies  >2305 publications with PTH and Connective Tissue
 Embryonic Tissue Antibodies  >232 publications with PTH and Embryonic Tissue
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